Conserved Protein Domain Family
Cluap1

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pfam10234: Cluap1 
Clusterin-associated protein-1
This protein is conserved from worms to humans. The protein of 413 amino acids contains a central coiled-coil domain, possibly the region that binds to clusterin. Cluap1 expression is highest in the nucleus and gradually increases during late S to G2/M phases of the cell cycle and returns to the basal level in the G0/G1 phases. In addition, it is upregulated in colon cancer tissues compared to corresponding non-cancerous mucosa. It thus plays a crucial role in the life of the cell.
Statistics
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PSSM-Id: 463013
Aligned: 39 rows
Threshold Bit Score: 223.226
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002904769         14 RSLGYP-RPISMENFRT-P-----NFELVSDLLYWMVKKYDPSSSIT-EEIDTEDDRVEFLTQVATEVLAKARIRLNPKK 85 
ESS29279             18 gftgsP---LSFGLFSSgP-----RFLSVADVLRWLALQCTGVKELPkRPLENADDRVAFVEQISELLARHASFCLDVET 89 
ETN60130             14 KLLGYP-NHIPLSVLTT-PyggpeSFKAYSDILQWLINRLEPNLVLA-GGTRSEQERVLFVRSATEFLVTKSSIKMNPRR 90 
EDW30817             14 KLLGFP-RVFPLQSLAN-QhgslaSFHIVSELIQWLAGLMEPGTVLS-GGVETEEQRVLLVRSATEFFVTKSAIRLNPRK 90 
WGS:AAPP:GF21268-PA  14 KLLGFP-RVFPLQALAS-PhgslaSFHIVAELLQWLAGLMEPGASLP-GGVESEEHRVLLVRSATEFFVTKAAIRLNPRK 90 
XP_010699716          2 RLLGYP-RLISMESFRE-P-----NVELVADCLHWLIIRYEPSAEVT-FNIEREHNRVTFFKQVCEVTLAKGRIKLNVKK 73 
EEH60284             14 RSLGYP-RIVSVENFRT-P-----NFELVADCLEWLAQRYDGGAVVE-DDISTETDRVRFLKSVAAVFLSKARIKLNLKR 85 
EFJ27015              6 KSLGYPgDGLSMESFRT-P-----HFDTVASCMRWLLPRYDPEVQLH-GDVSTEEGRIAFLKSAGRFMFLKTRMKLNLRS 78 
EAY18646             14 RILGYP-HPVGIDSFDT-P-----NFGLMANLLHWLATLYDPEIVIL-AELSNEHGRVEFVRGIVQQMAIKSGIRLNPRK 85 
XP_006679667          2 RGLGYP-KRISMESFRT-P-----NFDLVSDILYWLVKNYDPSIDIS-NDISSEQDRVIFVKSIALFMAPKAHIQLNTRK 73 
XP_002904769         86 LYAADGFAVKELIKLARVLYEASRIDla-----aqQEPDDDDDEVSV---------------------------KSMLGS 133
ESS29279             90 IYAAEGAAVKELIRLARTLLNAVQSAinrpalpatLEKQLQTISTSTavelmpvsrgdcvghsagrpdgaccidQLAMAA 169
ETN60130             91 LYASSMAAAQELLKVTSLLIASPKIT----------RHEEESIKSHL---------------------------EIDFSD 133
EDW30817             91 LYAAAAVTASELQKITRLLIAPSQTEa--------EREEEERDQYRSl-------------------------nQVDIGD 137
WGS:AAPP:GF21268-PA  91 LYAAASVTAAELQKITRLLTAPGGQTet------dHEDEEQRDQYRSl-------------------------nPVDIGD 139
XP_010699716         74 LYQADGHAVQEMLKLANVLKKAMKAT----------DAEEPDFTALH---------------------------QMAAQK 116
EEH60284             86 LYAADGLAVKELLKIANLLYQATAKAd--------EDDADEEASGGT---------------------------AFALDA 130
EFJ27015             79 LYMADSNATAELLQVSTLLEQAIASA-------------SSEKVCENfvf----------------------lfLTTLFK 123
EAY18646             86 LYASDRFAVRELLKIAVPIYRGISSS-----------------------------------------------------G 112
XP_006679667         74 LYTADGYAVKELLKIVNILYEAHTMR----------LDHNSNQSTIQ---------------------------PLDISN 116
XP_002904769        134 RVKDPKAT-----------RQLASDITQSGAKLYDLLDTELD------VRDARQQAIRfldalstnheNSSEQKFLERSI 196
ESS29279            170 KLQQLNLS-----------RSAASQLVDTAASLLQAFERHSRpervilRRRVRDFLLRlglh--ldsgADQELEHIQLQL 236
ETN60130            134 KMNDLKMV-----------RGLSSELTNKGAVLYDLLKKELV------NREIRNAQST----------RPIELATAEKVI 186
EDW30817            138 KMEELRRA-----------RELSSDLTQRGAALYDLLSKELQ------HKESRQTQAQ----------RPMELLSVERTL 190
WGS:AAPP:GF21268-PA 140 KMEDLRKA-----------RELATDLTQRGATLYDLLSKELL------NKEARTAQAQ----------RPLELLSVERTL 192
XP_010699716        117 NVSDAKAV-----------QQLCSELTTDGSSLFFLVEAELN------SRGDRQRILS----------RATEVGEFERRL 169
EEH60284            131 SAFDVKTT-----------RALASEITRLGATLHDALGEEER------LRDARLSATR----------KNMDIEEIESQI 183
EFJ27015            124 RAFDVKAA-----------RSLVLEIIKAGATLYDDLATEMQ------LQGERNMAAS----------TNTDIEQIENLV 176
EAY18646            113 RLADTKTTsfpknqntqkiSQLSATVPRHSVELYDQLDKEVQ------IRETRTKILS----------TVPSLDEVEKSV 176
XP_006679667        117 RIGKLKAS-----------RTLASEIIEKGAELYDLLGQEIS------LRDRRTDVIS----------RPFELAEMEQAV 169
XP_002904769        197 QDILVNLQENVELTERQVVELDAEEKALAAKIKKAQTDLERSEKRLKSLQ------------HVRPAFMDEYEKLEKELE 264
ESS29279            237 AEQLRRAKADLLDTQHACLDLENELT----------QDSDRAQKRLQSLQ------------NLKPAFLEDHKKLMAELQ 294
ETN60130            187 KGAISTVQSKLSGSTTALESLRNENTNLESKMRRKASELERSRQRLQALQ------------KVRPAYLEEFEKLEQELK 254
EDW30817            191 KNATQASQLKLQSSRAQLEAARVELNALNSKLQRKRAELERTKQRLEALQ------------KIRPAHMAEFEECEKELQ 258
WGS:AAPP:GF21268-PA 193 KNAIQSNQLRLQSSKAQLEATRVELNALGSKLQRRKAELERTRQRLEALH------------RIRPAHMAEFEDCEKELQ 260
XP_010699716        170 RELLTNVAQEVDQYQQSIVNLSADETNLEQKIENKKAHLERAQKQYKSAM------------ATNPAFLKEYENHEKKLQ 237
EEH60284            184 SEQIATVRENAANVERAMAELTEDESSLARQIERKRAELERSEKRLATLEsgafytkvfhppSVRPAYMDEYERLEPEMD 263
EFJ27015            177 REGTDSLLQTVSSVEQQQHSCEKDEKSLSITHEKRKVELERCKKRLSVLE------------NVRPAYLDEYEVLQSELQ 244
EAY18646            177 LESVDGAAARLEQLTKELDRLNSDEDALNTKIKQRKHEYERQSKRLMSVQ------------TIRPAYMEEYEMLEQELG 244
XP_006679667        170 TAAVNTLRDQMTVTRTGMDNLHSDEINLLAKIEKKKVERDRAEKRLKSLQ------------GVRPAYMDEYEKIEVELS 237
XP_002904769        265 RQYAIYCERFRNLDYLQRELDLHN-SREM 292
ESS29279            295 ETYDMYVACVRNERFLEMEAEKRQaKAra 323
ETN60130            255 GLYEQYIVRIKCVDTLRAQIISKN-RTPT 282
EDW30817            259 MLFQRYFLRLHVRDALRSQLEART-KRTT 286
WGS:AAPP:GF21268-PA 261 QLFQRYFLRLHVRDALRFQLESRT-KRAT 288
XP_010699716        238 AQFVNYLEQYRNLEFLEHQIAKYN-AKED 265
EEH60284            264 ELHAAYIERHRNLTYLESELEKIE-RDEE 291
EFJ27015            245 RLFGVYLEKFHNLRWLESQLETHN-QEEQ 272
EAY18646            245 ELFKTYFQHYRNVDYFEKEISKQAeKVKK 273
XP_006679667        238 RLYETYMEKFRNLAFLEQQLDEYN-REEQ 265
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