Conserved Protein Domain Family
MSC

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pfam09402: MSC 
Man1-Src1p-C-terminal domain
MAN1 is an integral protein of the inner nuclear membrane which binds to chromatin associated proteins and plays a role in nuclear organization. The C terminal nucleoplasmic region forms a DNA binding winged helix and binds to Smad. This C-terminal tail is also found in S. cerevisiae and is thought to consist of three conserved helices followed by two downstream strands.
Statistics
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PSSM-Id: 430586
Aligned: 110 rows
Threshold Bit Score: 185.572
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EKM55391     397 LLGTSVLTALGmYKTESASIGFCETGK-------------------------NTNDILEGmkvrrtaiqecnrenrttlf 451 
XP_011273519 625 FFTILIISSLW-YREQRILIGYCGLEIndktfp--------------ntdneILIKIDEFl------------------- 670 
XP_003959028 289 IIALPILFALW-YREQRIRVGYCGKELpliplas------------grtdnvFFQKIDSL-------------------- 335 
CCK69393     376 AIASVVLWGVW-YREQRIAVGFCHHELplkklcpdrliqiyqtfvldlsffdSI-------------------------- 428 
Q6FMP6       278 VIVLPILFFLW-YREQKIRVGFCGHEL-------------------------PVAKFAPYansnkvw------------- 318  [Candida] glab...
XP_003687595 251 SIILLCFFTLW-YREVCINIGYCGKELayppflktsitdkvl-------------------------------------- 291 
EJT44944     331 SILLPILFGLW-YREQRIRIGYCGHEEpiksla--------------fsafsQTARVDEF-------------------- 375 
XP_003676977 487 MFAVPVVFALW-YREEQIAIGYCNTRYelnntgttseh------------------------------------------ 523 
XP_003671605 567 LFAIPIVFALW-YREERILVGYCGHESvqsils-------------lsiespFFSCLDTI-------------------- 612 
XP_004180860 510 sILLPILFLIW-YREQKLATGYCGYSL-------------------------SPPSIIHSksnvfsqm------------ 551 
EKM55391     452 lahpdaaqdvpspqptqvatgtegsnvilseacpPPPLLPlprpeTCQLCPEHASCT-PTTVTCENGYLLR--PHPLLsf 528 
XP_011273519 671 ----------------------------------DQNLKP-----TCLEAPENSIALpYLQIKCKPDYIVY--QPWYK-- 707 
XP_003959028 336 ----------------------------------LKFVKP-----KCLPCPSNAKCYsLMDMDCYPQFKRY--SSIFK-- 372 
CCK69393     429 ----------------------------------LEKYAP-----KCIDCPENAMCFsHMRLICDAGYIAM--SSWKS-- 465 
Q6FMP6       319 ----------------------------asvdktLERFLP-----KCKLCPEGAICKtHLQMSCKDGYVLR--KSWWN-- 361  [Candida] glab...
XP_003687595 292 --------------------nnglfekydiksklSDLIIP-----DCTPCPDNAICYsSMKSVCNKGYVPE--NSFYN-- 342 
EJT44944     376 ----------------------------------LQAYAP-----NCLECPEHATCSsLMNIECESGYELK--SSILE-- 412 
XP_003676977 524 ------------------------helwnilgtyLEATKP-----KCIPCPEHASCYaNMQLICDNNYERT--TNYLS-- 570 
XP_003671605 613 ----------------------------------LSPFKP-----KCLPCPANAICHsNLATECIPHYETSafSSLLS-- 651 
XP_004180860 552 --------------------------ifkfdawlKQKFSP-----SCVSCPKNALYTfNMNANCQSGFEFT--YSFFN-- 596 
EKM55391     529 lpipsslrptdnrnaytnpslavaptygnkspldlaytglslimdgLPGLGPVafPPRCVE-DPMRKRHIGAMGRTIDSK 607 
XP_011273519 708 ----------------------------------------------IHGLLPF--SDYCIK-DTKKELIIKEVVSKSLEL 738 
XP_003959028 373 ----------------------------------------------LNGLIPL--TDYCII-DNTKEKLVNKMVNYMLKK 403 
CCK69393     466 ----------------------------------------------LNGLLPI--NGHCIK-DMKKDEILKDIFQSCLED 496 
Q6FMP6       362 ----------------------------------------------LESLLPL--ADKCIT--KRKAANKKTPLLFALDL 391  [Candida] glab...
XP_003687595 343 ----------------------------------------------LYGLLPL--PIKCSK-DKTEEKLVQDILNGVLYD 373 
EJT44944     413 ----------------------------------------------TYGVIPF--SKYCVK-DESKEKEVDELVWKVSEY 443 
XP_003676977 571 ----------------------------------------------LFKLIPL--ADSC---HEASAERVLEIANHLTDV 599 
XP_003671605 652 ----------------------------------------------LYGLIPL--PPSCEPiETEKSKELNQITSELLSV 683 
XP_004180860 597 ----------------------------------------------FYGLIPM--RRHCEK-MKLDTKKLNKILTNIMAI 627 
EKM55391     608 LAAERGRRLCDGARPDDkpgkvaqeakKWGVEVDALKESIRKdvikkSKSPS-QLLSTLDDT---FNEAIQQLVEWGGVF 683 
XP_011273519 739 LRIKNANVQCGDCTNDE----------IVGITNDELYEFFFN-----SKSNS-ITDEEFNEL---WVNVLKDLQNEPEIT 799 
XP_003959028 404 LRSKNGSVDCGTAKSDL----------ISGMIEDDLYDSIYE-----KFSNK-YSDDEFEEL---WSEALDKLEDLKEI- 463 
CCK69393     497 LRMENAEKNCGEGENNL----------ESGISSSILFEKHFRkviedQN----WSTYEGKQL---WGTVLDKLKGMPEVS 559 
Q6FMP6       392 LRTQNANTHCGSTLPDNy---------QAGMLEKDLFNNVYE-----EYRDM-MTKESFEKE---WAVLSNSLKRLPEIY 453  [Candida] glab...
XP_003687595 374 LRLKNSRVRCGDGETDE----------STGLIEKNMFDSFVS-------QKAwLSEKQRQRI---WRKVMLQLKKYPEIK 433 
EJT44944     444 LRKKNAQVDCGEGQNLF----------ESGETETKLYEIFSR-----SRPSW-ENQADFNEH---CRNVIEKLRHMDEIV 504 
XP_003676977 600 LRKQNARIQCGKGANDL----------KSGLSEKHIFNLLSL-------WYTwVHEENFDDL---WLNVQSELKKKPDIS 659 
XP_003671605 684 LHHQNAHLECGNSADNG----------LSGMNEGELYNEFMS-----YRSPW-INKEQYSEL---WVRVKAKLKNSKDIE 744 
XP_004180860 628 LTKKNTEaiyf------------lnsnYVTFSKDDLYEFLLGryfndGK-----------EVdiyFETVVKSLKNNPDIV 684 
EKM55391     684 IGEDEQG----------------------------HRYVAHRTPKLDMMCAVK-------VKALEYRDMWWKQ---AFGS 725 
XP_011273519 800 LRYTDIVdsnstqdnlstnevedetddiqqttersIIFRSNSKLKLSIKCKFQ-------KEIYDNFEKNKKI---LISF 869 
XP_003959028 464 --KISVTdiig--------------------pdqmKIIRSTSKKSIGLKCRLGspllknfRDVLSTCIKLRYV---TAII 518 
CCK69393     560 WSYREDElv-------------------------gINLRSHSRKYIGFGCRYG-------RHIKNTVMTYQHH---LIGL 604 
Q6FMP6       454 YKTFVSKnvagn-------------------ieniQLFRSLSKQNVSYFCGIF-----------KLLKEFPIEknvLFVA 503  [Candida] glab...
XP_003687595 434 LVNLYKKrldaddseaevvn---dhvfsiaekmshNLLRSTSKNFVPFYCGKS-----------DIIISSNYIkptLTIL 499 
EJT44944     505 WLPLDFEtgeeihf---------------kpnnttCVYRSTSKKWVKLPCHLG-------ADIRKGLRKYGVS---VLIT 559 
XP_003676977 660 FSVVPVEnst----------------------nstLWLRSNSRRYINLKCFFQ---------PTENIMKQSRY---IFVL 705 
XP_003671605 745 WHYIHPYsngslptn------------stsnteivTQFRSHSKKYVRVTCSLP---------KIEILPKLEEAlysVAFL 803 
XP_004180860 685 WKEVEDLsgsk--------------------ydkhNNVTISAVEEVFYSTKTN-------FPGFNYLFKNKLApflLMLI 737 
EKM55391     726 ----LAL--LLSA----WMAKHRRKQRLEDRERVTVLVDTVYDMLRNQELVHHTDPvsaprpYVPSTQLRDAVLQGE-HS 794 
XP_011273519 870 ----LTI--SILI----LIGYNKIKSIQKRNLKIKEISDIILIKLQKQSKNSQLDStgltkrFLSNIQLRDELLINY-HN 938 
XP_003959028 519 ----AIF--GIIS----FFTFKYTRKCLTRRKLITFYTEKAIEKLK--KAKRTRNNs----sGLDTLQIRDDVLSEV-TN 581 
CCK69393     605 ----IVA--LLVF----IIVKKRVKSYKIEQDKIRLYTENAIDRLKKSKLENNDPP------FVHTVQLRDVILADV-AD 667 
Q6FMP6       504 ----LTI--FSCTvtleIILQKLWKCQNRENAFVEKSTEKALEKLREASRDpe-------vkFLDTVQLREFLLSET-TN 569  [Candida] glab...
XP_003687595 500 ----VFLfsIVVL----CFLNKLIVNKLNDQTKCSVYIERIVEILKEIKENNKPQS------FLTSNQLKEIIFKDEvEN 565 
EJT44944     560 ----LIV--ILFI----KKIQSTLDDYVQGEQIIEQFVKEATDRLKSAKKNEDEEP------FLTTVQLRTILLRDI-PN 622 
XP_003676977 706 ----LLL--IFIIyglwNYVHGIFERRHGDAANIEQLFVTTLRLLQDAKKEkd-------mpFVNTLQIKDQIFKDI-KD 771 
XP_003671605 804 ----ILL--FITI----KVAKNEWTRRLKEQSYIRNLIKIAIQELKVNKREQIESP------FVNVLTIKSKLLNDI-SD 866 
XP_004180860 738 lsplLYI--IITI----FLITLVSYKTYLTRKKVQHIVQRVVIDLKSA---KRSDNsl---dYRNTTQIKELIFEEE-KD 804 
EKM55391     795 VATRQRLWKEVERIV--EANTNVRTNLEEv-AGGDEMRVWRWVGS 836 
XP_011273519 939 -KEKFKIWELILNNL--EKNSNIRILTKE--IHGEIVKVLEWIGd 978 
XP_003959028 582 LKDKNYFWSQMMKRMd-ADEKNIASTQIE--VHGEIIKYWNWIGN 623 
CCK69393     668 LHERNEIWGSMVKRM--DKDKNVLSSQME--IHGEIMRCWMWTGD 708 
Q6FMP6       570 LKKKNQLWDKISSKL--LENENVEKRQME--LYGEVLGIWEWNd- 609  [Candida] glabrata
XP_003687595 566 VEEQNRIWKKISNKL---ENSDIPVTSTQleLHGEILRSYEfelp 607 
EJT44944     623 IKEQNSLWARTKDKIikEYSENIELYLLE--ENGEIMTCLEWNd- 664 
XP_003676977 772 MRTRLNLWKKVSAKLe-EDKKQIKVYHLE--VDGEIMECWEWIDP 813 
XP_003671605 867 ADYKNYVWKEIKQKI--EQNPNVLTYHTE--LQGEIMKCWEWVGQ 907 
XP_004180860 805 MKTLRNLWKLIRLEL--SNYLEVTNYIKE--QDGEIIECWEWdsn 845 
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