1AUE,5FVM


Conserved Protein Domain Family
FRB_dom

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pfam08771: FRB_dom 
FKBP12-rapamycin binding domain
The macrolide antibiotic rapamycin and the cytosol protein FKBP12 can form a complex which specifically inhibits the TORC1 complex, leading to growth arrest. The FKBP12-rapamycin complex interferes with TORC1 function by binding to the FKBP12-rapamycin binding domain (FRB) of the TOR proteins. This entry represents the FRB domain.
Statistics
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PSSM-Id: 462596
Aligned: 83 rows
Threshold Bit Score: 87.6389
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1AUE_A          1 ELIRVAIL-WHEMWHEGLEEASRLYFGERNV-KGMFEVLEPLHAMMERGPQ--TLKETSFNQAYGRDLMEAQEWCRKYMK 76   human
XP_001311334 1609 ELMRVACT-RFELCYNCI----RDTLFEPN--EFTTKYLHQLFEQNSK--EneTFLDVSFSREFGNLLNLLEEWVKKYEE 1679
XP_001706690 2717 ELQRVAIL-WPEIAYDLITQASTAFCEEPRDlVKFFNYACQLQLLASRTPE--TQSESVFIQMFSSQLQAAWDSCRQFPV 2793
EAY20546     1712 EMMRVSVS-WFELAYQCIDESSHEFCPDVNK-QMMLKFLDPLKEILSK--KceTCMESKFFAQNYSHLKIAFGLLKKYEE 1787
EAY17625     1693 EMIRVAVT-WWEQWFGILDEASRAYLLRNDI-NEMCELLEPLNEVISKEPS--TYFEVSFLAQFGLSLANAHSCIKEYRR 1768
EAY10428     1712 EIIRIAVS-WWELWFGVLDDASRAYLIKQDV-NEMLSLLLPAHEITEKEPK--TYYEIAFVAQFGESLQRAKKMLMDYKK 1787
XP_001318165 1681 ELIRIGTS-WFEIWTQALEETSKMYDH-----VKAANILLPLHAVIEKPPE--TMFEVSFAAQFGSVLLQAHSLLDAFLN 1752
Q5K8Y1        341 ELIRTSISkWRGIIDGFL---PRQDLMEIKW-QDIPEIWEEDLRMLTN-PE--TPDEHQFVLQYGEQLHLVDKTLIRYNS 413  Cryptococcus ...
Q38AC2       1891 ELVRCAVL-WPELWINELGRALYQWERQRSA-ENLLLAMGPLLEQLKR-PE--TMAEAQFAAELRQPLENACCHVERAVS 1965 Trypanosoma b...
CAM73126     1993 ELVRCAVL-WTELWFDELERAWFQWGRDKNA-HNVFLVLQPLLEQLSH-PN--TLAESHFVAEFGELLGGACEYVEKAAS 2067
1AUE_A         77 SGNVKDLTQAWDLYYHVFRRIS 98   human
XP_001311334 1680 TKDHTHKNMIYNVMGQIWLKIK 1701
XP_001706690 2794 TNDLVCLNIVMKHYKEIYDRIH 2815
EAY20546     1788 NDDLGSLNEVWDHFSTVFNKLR 1809
EAY17625     1769 TQNEQCVLSAWQTYYSVYQDLK 1790
EAY10428     1788 TNDDIHLIQAWGIYISIFNQLK 1809
XP_001318165 1753 DHDEDAYNRAWSIYVPVLKKVR 1774
Q5K8Y1        414 SRQLNLVNNAYSTLYRLYGEIE 435  Cryptococcus neoformans
Q38AC2       1966 SRHEQFMEEARRIFVSIERRIR 1987 Trypanosoma brucei
CAM73126     2068 TGNNVYMEDAWNRFKTAVKRMD 2089
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