3UB0,2AHM


Conserved Protein Domain Family
CoV_NSP7

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pfam08716: CoV_NSP7 
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Coronavirus replicase NSP7
NSP7 (non structural protein 7) has been implicated in viral RNA replication and is predominantly alpha helical in structure. It forms a hexadecameric supercomplex with NSP8 that adopts a hollow cylinder-like structure. The dimensions of the central channel and positive electrostatic properties of the cylinder imply that it confers processivity on RNA-dependent RNA polymerase. NSP7 and NSP8 heterodimers play a role in the stabilization of NSP12 regions involved in RNA binding and are essential for a highly active NSP12 polymerase complex.
Statistics
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PSSM-Id: 285878
Aligned: 7 rows
Threshold Bit Score: 131.42
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3UB0_B    5 SKLTEMKCTNVVLLGLLSKMHVESNSKEWNYCVGLHNEINLCDDPDAVLEKLLALIAFFLSKHNTCD------LSDLIES 78  
P0C6U8 3837 SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD------INRLCEE 3910 Severe acute respir...
P0C6V3 3380 aKLSDVKCTTVVLMQLLTKLNVEANSKMHVYLVELHNKILASDDVGECMDNLLGMLITLFCIDSTID------LSEYCDD 3453 Avian infectious br...
Q98VG9 3500 SKLTEMKCTNVVLLGLLSKMHVESNSKEWNYCVGLHNEINLCDDPDAVLEKLLALIAFFLSKHNTCD------LSDLIES 3573 Feline infectious p...
P0C6U2 3547 SKLTDLKCTNVVLMGILSNMNIASNSKEWAYCVEMHNKINLCDDPETAQELLLALLAFFLSKHSDFG------LGDLVDS 3620 Human coronavirus 229E
P0C6V0 3922 SRLTDVKCANVVLLNCLQHLHIASNSKLWQYCSTLHNEILATSDLSMAFDKLAQLLVVLFANPAAVDskclasIEEVSDD 4001 Murine hepatitis vi...
2AHM_A    6 SKMSDVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVD------INRLCEE 79  
3UB0_B   79 YFENTTILQ 87  
P0C6U8 3911 MLDNRATLQ 3919 Severe acute respiratory syndrome-related coronavirus
P0C6V3 3454 ILKRSTVLQ 3462 Avian infectious bronchitis virus (strain Beaudette)
Q98VG9 3574 YFENTTILQ 3582 Feline infectious peritonitis virus (strain 79-1146)
P0C6U2 3621 YFENDSILQ 3629 Human coronavirus 229E
P0C6V0 4002 YVRDNTVLQ 4010 Murine hepatitis virus strain A59
2AHM_A   80 MLDNRATLQ 88  
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