5Z2Q


Conserved Protein Domain Family
Vg_Tdu
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pfam07545: Vg_Tdu 
Vestigial/Tondu family
The mammalian TEF and the Drosophila scalloped genes belong to a conserved family of transcriptional factors that possesses a TEA/ATTS DNA-binding domain. Transcriptional activation by these proteins likely requires interactions with specific coactivators. In Drosophila, Scalloped (Sd) interacts with Vestigial (Vg) to form a complex, which binds DNA through the Sd TEA/ATTS domain. The Sd-Vg heterodimer is a key regulator of wing development, which directly controls several target genes and is able to induce wing outgrowth when ectopically expressed. This short conserved region is needed for interaction with Sd.
Links
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Statistics
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PSSM-Id: 462203
Aligned: 12 rows
Threshold Bit Score: 56.6679
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5Z2Q_D        17 EWNAGSVIFTYFEGDINSMVDEHFSRALRN 46  house mouse
XP_002128412 109 HISSRCVMFNYFDGETSNEVDEHFTRALNH 138
XP_002128438  43 YIRSRCYLVTYFKGHPRDKVDEHFNRSLRH 72 
OCA25296      21 ELGSRCVVFTYYQGDINSVVDEHFSRALRT 50 
Q8BGW8        79 YINSRCVLFTYFQGDISSVVDEHFSRALSH 108 house mouse
XP_018961644  52 YLSARCVVFTYFRGDIGDVVDEHFSRALSQ 81 
EEC17208     101 YLSANCVVFTYYSGDISSVVDEHFSRALSQ 130
EFX86704     239 YISANCVVFMSYSGDTASVVDQHFSRALNa 268
Q26366       283 YLSASCVVFTNYSGDTASQVDEHFSRALNY 312 fruit fly
EGI65981      95 YVNANCVVFTHYRGDAASEVEEHFQRALAH 124
OXB67451      27 EWGAQSVVFTYFQGDINSMVDEHFSRALSN 56  scaled quail
VTJ61088      22 EWNSQCVIFTYFQGDINSVVDEHFSRALSN 51  woodchuck
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