2MH2,4Y66


Conserved Protein Domain Family
TBPIP
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pfam07106: TBPIP 
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TBPIP/Hop2 winged helix domain
This family consists of several eukaryotic TBP-1 interacting protein (TBPIP) sequences. TBP-1 has been demonstrated to interact with the human immunodeficiency virus type 1 (HIV-1) viral protein Tat, then modulate the essential replication process of HIV. In addition, TBP-1 has been shown to be a component of the 26S proteasome, a basic multiprotein complex that degrades ubiquitinated proteins in an ATP-dependent fashion. Human TBPIP interacts with human TBP-1 then modulates the inhibitory action of human TBP-1 on HIV-Tat-mediated transactivation. TBPIP was found to be an activator that specifically stimulates the homologous pairing catalyzed by DMC1. Family members also include yeast homologous-pairing protein 2 (Hop2) and its homologs from animals and plants. They are required for proper homologous pairing and efficient cross-over and intragenic recombination during meiosis.
Links
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Statistics
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PSSM-Id: 429296
Aligned: 13 rows
Threshold Bit Score: 67.0081
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2MH2_A        11 GAPGIILRYLQEQNRPYSAQDVFGNLQkeH--GLGKAAVVKALDQLAQEGKIKEKTYGKQ-KIYFAD 74  
Q8SSK7         7 DDEEAVFQMMYRCNRPTSKSEVVAYFK--G--EIGGTAIQEILDCLEESGRLITKTYGKS-KIYLVN 68   Encephalitozoon cuniculi
Q7RNH1       754 DAKEKIYKYMKQTNRPYSVVNVYDNLH--G--MISKNSVQRIMDELSIEKKLQCKEYGKA-KIYLIN 815  Plasmodium yoelii yoelii
XP_001704033   7 EALAAVKELMQSSNKPQNVQTAINNTG--S--RYGKATVQKALDELVAQNLCIYTEIGKTgKLYLWN 69  
Q9FX64         7 NTEAIVLNFVNEQNKPLNTQNAADALQ--Kf-NLKKTAVQKALDSLADAGKITFKEYGKQ-KIYIAR 69   thale cress
Q9P2W1        11 GAAGILLRYLQEQNRPYSSQDVFGNLQ--RehGLGKAVVVKTLEQLAQQGKIKEKMYGKQ-KIYFAD 74   human
NP_001124002  10 SSIILKYLNDQNRPYSTQDVFSNLQRD--HglGKTAVVKAMESLAQKGKIKEKVYGKQKI-YFADQE 73  
Q9HGK2        16 EAEKLVYEYLRKTNRPYSATDVSANLK--N--VVSKQVAQKALEQLRDTGLIHGKLYGKQ-SVFVCL 77   Schizosaccharomyces pombe 9...
Q6FXY7        14 DVCGVIQAYLEKQYKPFAINDIVSNLQ--KdyKFSKPVVLKALDTLVDEGRIVSKPFGKV-TIYCCK 77   [Candida] glabrata
P53187        18 EAEQLIEDYLVSQYKPFSVNDIVQNLH--N--KVTKTTATKALENLVNEKRIVSKTFGKI-IIYSCN 79   Saccharomyces cerevisiae S288C
Q752U9        90 EAEDLIERYLIEQYRPFGVNDIVQNLP--N--RVTKTNATKALETLVSQDRIICKLFGKA-AIYCCK 151  Eremothecium gossypii
NP_001002124   7 AAVARILAYLNEKNRPFSAQDVFTNLQ--KqcGLGKTAVVKAMEQLAQEGKIKEKVYGKQ-KIYFAD 70  
4Y66_B         7 eafaaVKELMQTSNKPQNVQTAINNTG--S--KYGKTTVQKALDELVAQNLCIYTEIGKTgKLYLWN 69
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