Conserved Protein Domain Family
GemA

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pfam06252: GemA 
Bacteriophage Mu, GemA protein
This family consists of several bacterial and phage proteins, including GemA (also known as gp16) protein from Bacteriophage Mu. GemA is an early protein responsible for decreasing host DNA gyrase activity, that promotes DNA relaxation of bacterial host genome. Modulates the expression of various host genes probably controlled by supercoiling of their promoters. Host genes affected include DNA replication and cell division determinants. This family also includes the Mu-like prophage FluMu protein gp16 from Haemophilus influenzae.
Statistics
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PSSM-Id: 428851
Aligned: 69 rows
Threshold Bit Score: 66.9335
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_011736248             28 VSDENYRAALESRFGVTTCKDLTLAQAKSFIDELQELA-HKTDQERYSreraaararaeagtpkrfdeldnrpgMASAAQ 106 Pelo...
jgi:Dshi_0097            21 MSDEGFRAALVQIAGVTSTKELDQDGLNAMMGFFEFCGfAPLRTKGPSygt--------------------rpgMASFAQ 80 
WP_040648221             23 nkeDPFHMIVYRISGKTSVRELTPPEAAAVEAELRRQLrEQRPKKKAAspe--------------------ypgKMTAGQ 82  Rumi...
CDC79772                 25 hkDDMLHNLVYNITGQDSVKQLTDVDYKKVVAELAQRIkISQLQPPSKsrsgnkr-------------ysttakGMTVGQ 91 
PRJNA421875:CXQ68_00425  24 ghDDELHALVDGLTGKESITALDRDEAQRVIAELMRR--MRGTPPVPParkkprh-------------yeeapgGITADQ 88 
jgi:Sgly_0527            30 LDDEDLYGIIGRETGKDSMRKLTQGEVDKVCRVLSNMKdDVNRAERGKrtde-------------------ggnPQTEKL 90 
CBL40386                 28 LTDEDLHAVVYRETGKESMKKLSQGEINTVARVLQNMKdGVERDTKAKride-------------------ggnAQTEKQ 88 
WP_021920672             27 LSDEDLHGVVYRETGKESMKKLTQGEITDVARVLQNMKdSAARSTGDKrtde-------------------ggnPTTERQ 87  Pseu...
Q72CZ9                   35 LDDETFRAMLRNLFGRESRKELNDHELALLCDHLATLG-ASFTAKDAPregkpfrrkaa----grrsdwyeipeGPLAAL 109 Desu...
Q30VZ4                   21 kDEVAYRGMLNNMFGVSSAADLDAKQRYRLIRHMEELG-AQFSSKGKTnpgqprqng--------dnfyvipdnAPYANQ 91  Desu...
WP_011736248            107 LRKIEAM-----WTDISDVPDPAARA---RALRRFLLRIAKVSD-----LRFLDDQMAGW-VINALNVMKHH 164 Pelobacter p...
jgi:Dshi_0097            81 IELIRVL-----WQEYTLGKAGE------AELNLWLERYWKLSS-----LRFLSAATAPK-IITALKAMKAR 135
WP_040648221             83 KAYAWRL-----LYDLAKLSPSAVPVg--ERMAGIVRKVLQEDPcpghpLNWVKREDGAK-LIEALKRYLRn 146 Ruminococcus...
CDC79772                 92 QRKVWAL-----MYQLAGCDTTVTVAtkgERLCGIIKKELHIDAspqkpFEWLGFEQGNK-LIELLKNYvks 157
PRJNA421875:CXQ68_00425  89 QRKVWAL-----MYELKKFDVKPVDAalgDRLCGIIRRQFGMDCtakkpMQFLDQAAGGE-LIEFLKNYCyn 154
jgi:Sgly_0527            91 RRKIYALtgelgWNNNN------------DRINGFVKKMFKVDR-----IEWLTVPQSHK-LIEALKKMVDR 144
CBL40386                 89 RRKIYALcdelgWNNDP------------RRLAGFVKRVTQVDR-----VEWLTIAQCNK-VIEGLKGILAR 142
WP_021920672             88 RRKIYALtealgWNNDK------------RRIEGFVKRMTGIDR-----LEWLNTAQCEK-VIEGLKAILAR 141 Pseudoflavon...
Q72CZ9                  110 KRKIAAM-----WRELGYDM---------TSLDTRVRRSFGVDA-----FRWLEDERHLRtLLADLETRlha 162 Desulfovibri...
Q30VZ4                   92 KRYILVL-----WKALGWSL---------KGIDTRMRKQFGLDS-----LVWVQDQAQLQtITKDLQNRCRK 144 Desulfovibri...
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