Conserved Protein Domain Family
GRIM-19

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pfam06212: GRIM-19 
GRIM-19 protein
This family consists of several eukaryotic gene associated with retinoic-interferon-induced mortality 19 (GRIM-19) proteins. GRIM-19, was reported to encode a small protein primarily distributed in the nucleus and was able to promote cell death induced by IFN-beta and RA. A bovine homolog of GRIM-19 was co-purified with mitochondrial NADH:ubiquinone oxidoreductase (complex I) in bovine heart. Therefore, its exact cellular localization and function are unclear. It has now been discovered that GRIM-19 is a specific interacting protein which negatively regulates Stat3 activity.
Statistics
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PSSM-Id: 461852
Aligned: 32 rows
Threshold Bit Score: 141.614
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFX90408       4 TIKQDLPPPGGYEKIQYARNPAKTFFRGGRLLAGFIILNGCTTYYYFNHiYPGILHRR--VEKKGSHLATLPLLLAEQDR 81 
2_pfamImport   1 KVKQDMAPPGGYGPIDYKRHLPRRGLSGYSLFALGIGSLLLGYYTLVKW-NRERSPSQphSQSLPARSQSLPVPPALFPV 79 
Q95KV7         5 KVKQDMPPVGGYGPIDYKRNLPRRGLSGYSMFAVGIGALLFGYWSMMKW-NRERRRLQ--IEDFEARIALMPLLQAEKDR 81  cattle
XP_005999477   5 KVKQDMPPLGGYGAIDYKRNLPKRGLSGYSMFGLGIGVLLFGYWKLFKW-NRERRRLL--IEELEARIALFPLLQAEIDR 81 
XP_007238486   5 KVKQDMPPPGGYGPIDYKRNLPRRGLSGYAMFGIGIGVMLFGYWRMFKW-NRERRRLL--IEELESRIAILPLLQAERDR 81 
EDO40111       3 TIKQELPPKGGYAPLGFTKNLPKRGVSGWLTILGGAAVMTGGFAMVIRG-NRQRCELR--KEQLQARIALLPLLQAESDR 79 
XP_002110536   7 KMRQEMPPKGGYPMVEYQRNLPRRGVSGAAMIIGSAAIMSFGFYLVIKG-NRHRRVLK--QERLEARHFVRPLIQAEEDR 83 
EFC42254      39 ELNQDVAPQGGFPAVRVRRNSPNKFWSIGTFLFISTAVMAYGWYRYYKW-IKKRDELK--KEREVLELAMTPFLQAEHDI 115
XP_002892230  19 PLLQDGPPPGGFAPVRYARRISNTGPSAMAIFLTVSGAFAWGMYQVGQG-NKIRRALK--EEKYAARRAILPILQAEEDE 95 
XP_001760295  19 PVLQDGPPPGGFPAVRYARRIANTGPSGVTVLLVSSAIIGWGMYQVGQG-NIYRRGLK--AEKIAARQAILPLIQAEEDA 95 
EFX90408      82 AFLKHCRALRDEEEKLMANVPGWEVGkwngQPIYKTldKDVFSNPILSEYYCHAP 136
2_pfamImport  80 PTLRMLRQNLDEEAKIMRDVPGWKVG----ESRFHT---DRWVPPTPEELYFLR- 126
Q95KV7        82 RVLQMLRENLEEEATVMKDVPGWKVG----ESVFHT---TRWVTPMMGELYGLRA 129 cattle
XP_005999477  82 RALRLLRENLEEEAKIMKDVPGWKVG----ENLYHT---DRWVPPMTDELFNLRP 129
XP_007238486  82 QMLKMLRENLEEEAVIMKDVPGWKVG----ESVFHT---DRWVAPLSEELYNLRP 129
EDO40111      80 RVLRGLKENEELEALIMKDVKGWNVG----ESVYHT---NKWVTPMPEQvl---- 123
XP_002110536  84 RILRRLKCLEYEEAKIMQNVPGWVIG----ESVYHT---DRWVQPPAEqlsrf-- 129
EFC42254     116 AFTLQRRAFLKKVEELMKGEPEFNAY----EKFYNS--TTRFQYPVYNaqlrhfk 164
XP_002892230  96 RFVSEWKKYLEYEADVMKDVPGWKVG----ENVYNS---GRWMPPATGELrpdvw 143
XP_001760295  96 RFVREKNKLLEEEAKVMANVPGWKVG----ENVYNS---GRWMPPSSGklgmds- 142
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