6GVW


Conserved Protein Domain Family
BRE

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pfam06113: BRE 
Brain and reproductive organ-expressed protein (BRE)
This family consists of several eukaryotic brain and reproductive organ-expressed (BRE) proteins. BRE is a putative stress-modulating gene, found able to down-regulate TNF-alpha-induced-NF-kappaB activation upon over expression. A total of six isoforms are produced by alternative splicing predominantly at either end of the gene.Compared to normal cells, immortalized human cell lines uniformly express higher levels of BRE. Peripheral blood monocytes respond to LPS by down-regulating the expression of all the BRE isoforms.It is thought that the function of BRE and its isoforms is to regulate peroxisomal activities.
Statistics
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PSSM-Id: 461832
Aligned: 7 rows
Threshold Bit Score: 459.211
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6GVW_C        12 NRISPMLSPFISSVVRNGKVGLDATNcLRITDLKSGCTslt--pgPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFI 89 
OWR52447      10 NEISPMFRPYIQSIYQDLKLGLCKAK-VDLERIGGNSS-------GAESQFRLVLPYCSKKLKWDVIFDTSTPWFAPDFR 81 
B6NXD5         9 KQLHPLIRPYAETVLRKGNVGVCMGN-LRISDVKSGRPtltqtkePCGDRFKIYIPFAGDSLKWEVIFDSCQPSNPPDFI 87  Florida lancelet
EFN65095      10 STIDSYIEPLLKRVLQTKRLGVCCGL-IKLDSVSSSCNk------SKNDCFKLSIPYAGEHLVWSVLFDSQYPEMGPDFI 82 
EFN76708      13 NTIDPYTEPLLKRVLHSKRLGISYGG-VKLNKGPTSCNk------SSNDCYKLTIPYAYENLLWTVLFDSQYPEIGPDFI 85 
XP_012062756  10 sTIDSYIEPLLKRVLQTKRLGVSYGP-IKLDSVSSSCNk------NKNDCFKLLIPYAGEHLMWNVLFNSQYPEMGPDFI 82 
XP_850681      8 NRISPMLSPFISSVVRNGKVGLDATNcLRITDLKSGCTslt--pgPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFI 85 
6GVW_C        90 F-GEDAEFLPDPSALH----NLASWNPSNPECLLLVVKELVQQYHQFQCGRL-RES-SRLMFEYQTLLEEPQYG-ENMEI 161
OWR52447      82 FdDDSFLSSANEDYLTksvpSLTNWDANNPKSLGDVLSELIKLYKIHQVRKLhEDAnSRASFEYSALMGNALTTeKDVEV 161
B6NXD5        88 FlGENGNFDPDIEKLE----NLTHWDPKNPESLVLAIEDLMREYRCYQKQLI--EGySRLQFEYSSLQGMEAC--DDVEV 159 Florida lancelet
EFN65095      83 FnDQSFLADPDINTLStwipSLTKWNPNDIDALLNVLSELLLYYKEHQLHLLgKQG-DRLQFEYSTLVGETEISrEDIEV 161
EFN76708      86 FnDQTFLMDPDIDILStkvpSLVKWDPTDSDALLNVLVELLLYYKEHQIESLaQQG-DRLQFEYSTLVGNTELHvDDIEV 164
XP_012062756  83 FnDQNFLMDPDIDILStwvpSLVKWNPNNTDALLNVLMELLLYYKEHQILLLgKQG-DRLQLEYSTLVGETEICkEDIEV 161
XP_850681     86 F-GEDAEFLPDPSALH----NLASWNPSNPECLLLVVKELVQQYHQYQCSRL-RES-SRLMFEYQTLLEEPQYG-ENMEI 157
6GVW_C       162 Y---AGKKnnwtgefSARFLLKLPVDFSNIPTYLLKDvneDPGEDVALLSVSFEDTeatqVYPKLYLSPRIEHALGgssA 238
OWR52447     162 W---VGGH-------IVEFLIKLKVDVLRLPELYNDGteqNPGIDTALLLVRYPNS----TNAELILSPFLTKVLG---K 224
B6NXD5       160 H---MGNRlpgtldsPVNFLIRLPIDLSPIPQYLVKD---DPGEDLAVLLAKFHNSegsrVTPQLFLSPKVEHALGdntA 233 Florida lancelet
EFN65095     162 ImlpLGTKp-----tEARFLIRIVMDYSRLPPRINKS-----QNDEAMLIIMFYGPdwnrIIPQLYLSKTLEDIFGgpeS 231
EFN76708     165 IllpLGGKp-----vEARFLIRISMDCC-LPPCVDKL-----HDNETMLHITFYGPdwnrIIPKLYLSKTLEKAFGgpdS 233
XP_012062756 162 Mv-lLGLKp-----mEARFLIRISMDYTRLPPRINKS-----QNDEAMLLVTFYGPdwnrISPQLYLSKTLEDAIGrpeS 230
XP_850681    158 Y---AGKKnnwtgefSARFLLKLPVDFSNIPTYLLKDvneDPGEDVALLSVSFEDTeatqVYPKLYLSPRIEHALGgssA 234
6GVW_C       239 LHIPAFPG-GGCLIDYVPQVCHLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGftkLTLLLMWKDFCFLVHID 317
OWR52447     225 ITLPMMHH-SGVLMDYVPLVTEILNNKIYHLLNNDKLKRDLLAQLIVKYEGAILEHDASS---AALLLQMNDFYWILQVD 300
B6NXD5       234 LRIPRFPT-GGCLMDYVPQVQDFLQKQIDHIVEGYQRRREYVAAFISRFGGSVLEYDAESftkLSLVLEWNEFFFVLHIE 312 Florida lancelet
EFN65095     232 LHIPPFPS-SKYLMDYVPEVKKFIDEKIHNVVQSFESRKSFITVLIVSQRGSILEYDAIEfnwISMLLEHRDFHFLIHFH 310
EFN76708     234 LHLPPFPPtTKYLMDYVPEVKKYIEEKINAVVECFEKRKDFLAALLMIQSCSLLEYDTKEfdyCTIMLEQLDFHVLVHFY 313
XP_012062756 231 LHIPPLPP-NKYLMDYVPEVIKFMEEKINSAIQCFENRKEFIVFLLVLQRGSIVEYDAIEfnwIIILLEHRDFHFLIHFN 309
XP_850681    235 LHIPAFPG-GGCLIDYVPQVCHLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGftkLTLLLMWKDFCFLVHID 313
6GVW_C       318 LPLFFPRDQPTLTFQSVYH 336
OWR52447     301 IGIKFPEKPPVLTLRSVYY 319
B6NXD5       313 LPSRFPQDMPVFTFQSCYH 331 Florida lancelet
EFN65095     311 LPSTFPKEKPQITLQSVYH 329
EFN76708     314 LPPGFPKESPQITLYSVYH 332
XP_012062756 310 LPSIFPKEKPQITLQSVYH 328
XP_850681    314 LPLFFPRDQPTLTFQSVYH 332
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