Conserved Protein Domain Family
FIBP

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pfam05427: FIBP 
Acidic fibroblast growth factor binding (FIBP)
Acidic fibroblast growth factor (aFGF) intracellular binding protein (FIBP) is a protein found mainly in the nucleus that is thought to be involved in the intracellular function of aFGF.
Statistics
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PSSM-Id: 461649
Aligned: 18 rows
Threshold Bit Score: 472.566
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEN41942       2 TSVNVFVTNNTYIDFDVFGHWLNGLTVHEAVQARLQSGILQSTGASPDMLQSDTLDNYRTFSLLERFLQSPPK-L-ATQV 79 
EFX71175       3 cSVDVFVGNSTIIDPEIYQLWVDGNSSHEAADILQQRGILQQWGANMDLLMSDVLDHYRTFHMLEKTLHTPLKsTaAGEW 82 
XP_015792765   6 TEVDVFIGSNTIIDEHIYTCWLDGYTPQETAILVKEKECIVLRGIHDDLIISDVLDQYRLFGLIERLLQSPSM-I-GQGW 83 
XP_011416053   2 TAVDVFVGNYTLIDSELYGLWLNGYSAQDAALFLQKSGVLQKADVSMEIVYSDIQDQYRLFFGLEKLLQSPPK-L-IDQQ 79 
Q2YDE0         3 SELDIFVGNTTLIDEDVYRLWLDGYSVSDAVALRVRSGILEQTGATAAVLQSDTMDHYRTFHMLERLLHAPPK-L-LHQL 80  cattle
OCA37225       3 NELDVFVGNTTLIDEEVYQLWLDGYSVSDAVNIRLKSGILDQTGAGADVLESDTMDHYRTFQMIERLLHYPPK-L-VQQL 80 
2_pfamImport   1 MELDVFVGNTSLIDEEVYQLWLDGYSVSDAVCRRSQSGILEQASATSDVLGSDTMDHYRTFQMLERLLHHPTK-L-VNQL 78 
XP_007254251   3 MELDVFVGNTTIIDEEVYQLWLDGFSVADAVKMRLENGALGECEVSGEVLHSDTMDQYRTFQMCERLLHCPSK-L-ANQL 80 
NP_956703      3 VELDVFVGNTTIMDKEVYQLWLNGYTVNDAVKVRIEGGVMEECEASADVLLSDTMDQYRTFQMCERLLHHPAK-L-ANQL 80 
EEC03150       3 AEVDVFVGNNTLIDPDVFQLWLEGYSAQDAAVTLHHNEVMKESDIPLELLKSDVLDHYRTLQMLERLLHSPVH-L-AEQW 80 
EEN41942      80 LLQIPAAVQRTLIEKYYDFDSTVIREILGKKLTNRHRKDVDDVSERTNIRLRSCR--RQYDNCKN-----IFKTVEDMEG 152
EFX71175      83 TFQMEADTQQLLIEKYYELDDVVVREVLGKKLSSRHRKDLDEVSEKTAISLRSCR--RQFDNVKR-----IHKLVEEMPG 155
XP_015792765  84 SLQINAKTRRLLIEKYYEFDDCVVREILGKKLSSRNRTELKDVSEKTSVGLKSCR--RQFDNVKR-----VYKAVEDMGG 156
XP_011416053  80 IYQMDTDMQRQVIERYYQFDSVVVREILGRKLSSRNRKDMDDVSEKTRIPIRSCR--RQFDNLKR-----VFKTVEEMMG 152
Q2YDE0        81 IFQIPPSRQALLIERYYAFDEAFVREVLGKKLSKGTKKDLDDISTKTGITLKSCR--RQFDNFKR-----VFKVVEEMRG 153 cattle
OCA37225      81 LFQIPPYKQSMLIERYYAFDEAFVREVLGKKLSKGTKKDLEDISSKTGVTLKSCR--RQFDNFKR-----VFKVVEEMRG 153
2_pfamImport  79 LFQIPPHMQALLIENSVGFRDVTRHWVLGPGLKKKKKKNQGGVTKKQRITEKLTW--RYHSDPEQscshgVF-----MQG 151
XP_007254251  81 LFQIPAHHQAMLIERYYEFDHMFAREVLGKKLSKGTKKDLDDISSKTGIALKSCR--RQFDNFKR-----VFKVVEELKG 153
NP_956703     81 LFQIPPDRQAMLIERYYAFDDLFVREVLGKKLSKGTKKDLDDVSAKTGVSLKSCR--RQFDNFKR-----VFKVVEELKG 153
EEC03150      81 TFQLTPQTQRMLIAKY---DGFFTPLILCYKCSISVRKYTIEI---------NCRlnSPFDNIKR-----VYKVIEEMPG 143
EEN41942     153 SLVNNISGH-FLLPEKLAKRYAAIVFFSNNRFETgKKKLQYLSFDDFAYCADLMIHNWTFGAagngp---slydSQAD-D 227
EFX71175     156 HIVHNIQHN-FLLSAELSKKYAAVVFVAVNRFETnKRKLQYLNFGDFYHCAHQMIVHWSSTAschatsvrnqleTETEiE 234
XP_015792765 157 NLIFNIQNN-FLLSERLAKRYATVVYIANNRFETsKRKINYLKFADFYHCAYQMMTNWSCKNp----------eCKYE-E 224
XP_011416053 153 SLVENIKTH-YLLSEDLARQYAAIVFIANNRFETgKKKLSHLSFEDFVFCANQMITNWSYSSv----------eCTVHaD 221
Q2YDE0       154 SLVDNIQQH-FLLSDRLARDYAAIVFFANNRFETgKKKLQYLSFGDFAFCAELMIQNWTLGAv----------dSQVD-D 221 cattle
OCA37225     154 ALVENIQQN-FLLSDKLARDYAAIVFFANSRFETgKRKLQYLTFEDFATCAEHLIQNWTLGAv----------dV-AD-D 220
2_pfamImport 152 TVVLFLLCHtYWLSTGVAGDYAAIVFFANNRFETgKKKLQYLTFEDFAYCAEQMIQNWTLGAv----------dSMVD-D 220
XP_007254251 154 PLAENVQHH-FLLSDLLAKDYAAVVFFANSRFETgKKKLQYLSFQDFAFCACQLISYWTVGAv----------dNMMD-D 221
NP_956703    154 PLVENIRQH-FLLPDQLARDYAAIVFFANNRFETgKKKLLYLTFQDFAFCAGQLINHWTLGAv----------dSMME-D 221
EEC03150     144 PLTKNIQTH-FLLPEQLARKYAAVVYITHNRFETgKKKLNYLTLDNFIFCVDQMINNWSCRNpsnlr---lhttSLAYeE 219
EEN41942     228 mDVEMDRVFLQELRDLKVLTgEKDvyEKHKGLVCSALRGKIPDPT------YADIESNFKNLSRCIVSVASGLIHSKELK 301
EFX71175     235 tDLDVDRGFLHDLREVRILL-DKE--KEHKHLVCSQLKGRLTDKI------YADMESSFKTHSRSLVSLAGNLNRSRELR 305
XP_015792765 225 sPMDIDREFLQDLRELKVLL-EREymDEHKINFMRELKSKSVDRMdrldkqINDLDSLFKNTSRSIINIAFRLNQGKEVR 303
XP_011416053 222 mDVDLDRGFLHDLRELKMIS-EKEvlDEHKGQVISHLKPSLTKKS------RQVLEESFKNNSKAIINIACGLNHSKDVR 294
Q2YDE0       222 mDMDLDKEFLQDLKELKVLVaDKDllDLHKSLVCTALRGKL--GV------FSEMEANFKNLSRGLVNVAAKLTHNKDVR 293 cattle
OCA37225     221 mDMDLDKEFLQDLKDLKILItDKDllDQHKSLVCTSLRGKI--SV------FHEMDSNFKTLSRALVNIGTSLTHNKDVR 292
2_pfamImport 221 mDVDLDKEFLQDLKDLKVLVtDKDllDQHKSLVCTALRGKI--SN------FTEMEASFKKIDRYCVAVKMSIIYFTWVF 292
XP_007254251 222 mDVDLEKEFLHDLKDLKVLVnDKDmlDQHKSLVCSQLRGRI--RV------FTEMEANFKNLSRALINIASKLTNTKDVR 293
NP_956703    222 mDVDLDKEFLQDLKDLKILItDKDllDQHKSLVCTALRGKT--SV------FNEMEANFKNLSRGLVNIAAKLINAKDVR 293
EEC03150     220 sGMEMDREFLQQLREMKALL-DREhlDRLKDAVTFSLWGRVSKHT------LQDLESNFKSLTRTLVNIAYGLNHSKDLR 292
EEN41942     302 DFFV----DLvEKFIEPCRNARWSKRDVEAFLKAYEAAIQQIPQLKRCPHLLTVWTRYMTTL---KKCILQLY 367
EFX71175     306 SLFV----DLvERCVEPLRQARWTSRDLRLFLDYYTPAGVQL--FKSDSATALVWERYMKVI---SSCLVKIY 369
XP_015792765 304 DLFL----DIvDKIIEPFKAYKLVKSDLEVFLQLYMESPKNMEVFVRNPDLWVVWLRYMRTL---NSCIIQMY 369
XP_011416053 295 DIFV----DLvEKVTEPCMSAGLSGSDMEAFLNAYKDTIVRMDVFRLQPHMLAVWDRYMKTL---KLCVLQIY 360
Q2YDE0       294 DLFV----DLvEKFVEPCRSDHWPLNDVRLFLNQYSASVHSLDGFRH----QALWDRYMGTL---RGCLLRLY 355 cattle
OCA37225     293 DFFI----DLvEKFIEPCKAAGWSFSDVQLFLTQYTASARALDAFKQ----QALWERYMGTL---RSCLLKMY 354
2_pfamImport 293 FFFFpplcECmKQFIEPCKSEKWTINDVRLFLTQYTNSARALDAFRY---------HYICLLvvnTRCFGVFF 356
XP_007254251 294 DLFI----DLvEKFIEPCRSDKWTAGDLTLFLTHYTSTASTLETYRY----QVIWERYMGVV---KSCILKMY 355
NP_956703    294 DFFI----DLvEKFIEPCRSDKWTSIDMNLFLTHYTNSAHILDTFKH----HAVWTRYMGVI---KSCILRMY 355
EEC03150     293 DFFI----DIvEKIIEPCRSAHWTREELQVVMEAFSKSPQSA-TFPHELHLYEVWVRYSETF---AKCVCQMY 357
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