Conserved Protein Domain Family
TAP42

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pfam04177: TAP42 
TAP42-like family
The TOR signalling pathway activates a cell-growth program in response to nutrients. TIP41 (pfam04176) interacts with TAP42 and negatively regulates the TOR signaling pathway.
Statistics
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PSSM-Id: 461209
Aligned: 147 rows
Threshold Bit Score: 146.593
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPE05987      10 LKATHRAAERKRD-AIETGavrysPADPDAYGDAVRGAIAAYEKCDRLVAQLALFSTNESAEDIATGHLPYLLVPFYIAE 88 
Q57XV0        15 VRSLFNGLAQRYKdTVl------kSETSIEQDENSRSLIPHLEKLWYMMGAMGVVSPNEQLDDISTNALELLWTPYIIAD 88  Trypanosoma brucei
Q4DEG1        10 VKGRFNELLRQYEeGILG------GMHSGEQSTIARSLIPHFELLWRQMAVMGVVSSNEQLDDLSTSSLELLWIPYIIAD 83  Trypanosoma cruzi
XP_002880896  11 LSALFEQARKIHLa----------ASESGTDQDVVKKGCEMFQKCEDMIGKLGLFSSNETKEDISTNNLKYLLVPYYLAE 80 
XP_010316147  11 LPALFEQAKKIHDl----------ASESSVDQGIVRKGCEILRVCEEMIGKLGLFSLNETKDDISTANLKYILVPYYLAE 80 
EDQ72779      10 LPQLLTQAQQIHSl----------ANSSQIGNDEVKKGCQLLRKCQEIADRIGLFSTNEEKEDISTGDLKYLLVPYYLGE 79 
EFJ30093      10 LPLLFQRAQALHTr----------STSSQLDPDELNKGIRLLLQCQEMVDKLAIFSSNEKKEDVSTSDLKYLLVEYYLGE 79 
XP_005849467  12 LPALFQRGRALLK-QLEGL-----PASDAGTQQLVQRGGAVWRQAAAAADALALFSSNEELEDLATADIKYLLIPFYAAE 85 
XP_002504031  38 LDVYTR------------------LQSTSVDDDEISQAAAALRQAALQADRAGVLSANEVLDDIATSDLKYVLCEFYLAE 99 
XP_003054916  17 LAAYTK------------------LQSGALDEETLASAAAALRHAVNRIDVEGVFSKNETKDDIATADLRYLLAPFYLAE 78 
EPE05987      89 LALKIPAysstst------------pasrpAERRAVLKRAREAYERYLHHLDGYSLLTANYVRLL------QAYTEdpke 150
Q57XV0        89 LYQRLQGpmptpapvtpg--etnevagaagMTREEALSRSHHWYDVFFRWAQDCELVDERTLDTYrtf------------ 154 Trypanosoma brucei
Q4DEG1        84 LYQRIQGpiptleatsllsssapetrntsdMTREEALTLSKGWYDIFFQWMLDYELVDERTLEKYrnm------------ 151 Trypanosoma cruzi
XP_002880896  81 LTEKIIQ-----------------------EDRIQIVKASYAKLKEFFSFCEAMELVPDEELEASsrs-sgAPA------ 130
XP_010316147  81 LTEKIAE-----------------------DDRIEVLKASQAKLKEFISFCETMELVPEDEIETStqggssSSV------ 131
EDQ72779      80 LTEKLET-----------------------EDRVQLVRVAKGQLLSFIRTCERLELLSESDAQVLsregraTPE------ 130
EFJ30093      80 LTERTPA-----------------------TERIDVVRAAINHLKTFVRSCELLDLVPEGELVALtrdtpvDPA------ 130
XP_005849467  86 ALTHTHAad--------------------pRARIAALTSAAEQYRAFLHRCRQYGLLSPPATAMAdaalqqgdgggdh-- 143
XP_002504031 100 VVSRTRApn--------------------pAARAPFAAEAADALEAFLRRCEVHDLLTPEAKRQReglkrgPGAQNad-- 157
XP_003054916  79 VVGSTRTra--------------------pAARLPVATEASSAHATFLSWCERHEFIPRGDGDGAsassaaADPA----- 133
EPE05987     151 fstvgsvsgsstgvgagrapkaglagladptARRNAKIANFQAEKELRGKLDVLKQRQQQRreikrrrkirireaeeeta 230
Q57XV0       155 -----------------------------raDNRTQRVELSRKRRELEVVLLQYEDKVEYLqakrkrmkel--------- 196 Trypanosoma brucei
Q4DEG1       152 -----------------------------hpDQRTQRVELSRKRRELEEEKRRYEQQVQYLlakrkrmqal--------- 193 Trypanosoma cruzi
XP_002880896 131 -------------------------------DRRALKIARFKRQKAAEAKLLEIKERKERRgrstkas------------ 167
XP_010316147 132 -------------------------------DRRAKKIARFKRQRAAESKLLELKERRERRgrstkaa------------ 168
EDQ72779     131 -------------------------------TRRAEKVARFRKQRAAESKLQEIKERKERRrrsmqat------------ 167
EFJ30093     131 -------------------------------TRRAEKITRFKRQRAAESKLQEINERKERRrrsmqaa------------ 167
XP_005849467 144 -------------------gskqqgrtldaaTLRQNKIEKFKREKYVKGRLAELEQRQRQQagageg------------- 191
XP_002504031 158 -----------------------------pgTARADKVARFRRERAIRARLEELDVTRRRRaeeallnad---------- 198
XP_003054916 134 -------------------------------TARDRKVARFKRERAIRARLEDLDAKRRARrqdallnaew--------- 173
EPE05987     231 dnagstedahndgadddddddddDDDED-----EEEARKLYMAQVFYSVHMAFQGLDGINVEDDMLASAPvpqnngsvrg 305
Q57XV0       197 -------------maedgdeiseSNGDE-----EEALRGRALARLRWSVYEACHHLQLSARELEMLTALSperrqeiann 258 Trypanosoma brucei
Q4DEG1       194 -------------aeedgdeledTNGDE-----EDALRNRALSRLRWSIYESCQQLQLSFRELEMLQALSleqrqaiaid 255 Trypanosoma cruzi
XP_002880896 168 ----------------alstpveSGEEDipdddSEEEREAWLSSINLAICKAIDLLEMLKREEEMLSAIKerqlkdgedg 231
XP_010316147 169 ----------------alsspveTGEEDvfdddGEEEREAWLTTISLALCKAFDLLEMLKKEEEILSAVRekqlrdgeke 232
EDQ72779     168 ----------------akstsveQGEENlpdedDEEEREAWFLQISLALCKSLDLVEMLQREEEMLAAVQaaneegreaf 231
EFJ30093     168 -----------------gkqvvdYGEEDipdgdDEEEREAWFVQLSLAVSKAVDLLEMLQREETMLLAVRkenenggefa 230
XP_005849467 192 -----------------ehaggqRGGDA-----EEADRELWMLQADLAALQAAERMGTLQQEVQILAHAAampeqqrqr- 248
XP_002504031 199 --------------wddedpdasPE--D-----EVEERERWTLLIEDAVAKSLDNLDHLARELEMIAARDelaaarpagr 257
XP_003054916 174 -------------ddedpecgqdDGGED-----DAEARERWTLAIEDATIKASDAKPRLELELTMLRDREaleasaasrr 235
EPE05987     306 gssstagglgdnrqrsgrgiddelseridqldmqngaslqrlqgalgagaptwagtrggplltkeGRP------------ 373
Q57XV0       259 h------------------------------------------------------qrtldavrrgELSlgrhtytilpgg 284 Trypanosoma brucei
Q4DEG1       256 h------------------------------------------------------qktieavqrgEKSlgrhtytilpgg 281 Trypanosoma cruzi
XP_002880896 232 fsrdaldd---------------------------------------rtkkaetwhrdaaariqySKP------------ 260
XP_010316147 233 fsqlilde---------------------------------------rtqkveswhrdaaararyTKP------------ 261
EDQ72779     232 skemlder----------------------------------------hsraddwhrqgaakaqtSRP------------ 259
EFJ30093     231 qavlder-----------------------------------------hakaeawhresatkskvLRP------------ 257
XP_005849467 249 ---------------------------------------------------------ereqrqqaGPP------------ 259
XP_002504031 258 praggvnaragrgvy--------------------------tlmpdgavvpgfhdasngsassigGQPtgqq------ta 305
XP_003054916 236 naddgggeeeeeeeggevg-----------------errirgrgggggggglktytirgkdgdgrGQS------------ 286
EPE05987     374 -KQP----------FTITagsn------------------------------mgigNNRAQMAKNVFRPGHNL------P 406
Q57XV0       285 lVAPggpfpvdrinSTVMsa-----------------------------------iASQESFRQKVVE---ELminrnnP 326 Trypanosoma brucei
Q4DEG1       282 lITPggpipttqvgSVAMsa-----------------------------------iANQQAFRQKVVK---DLmvernpP 323 Trypanosoma cruzi
XP_002880896 261 -AQP----------ITCAtfaqdvlegrasvsqghdh-knqplifgpasivggplsTERERMIAQVFQPSHRM------P 322
XP_010316147 262 -AAP----------ITCAtfaqdviegrakvsqahdh-khqpllfgpaslvgmnptTERQRIAAQVFQPHYRL------P 323
EDQ72779     260 -AIP----------ITCAtyaqdviegrvaiqpnhqhthgapmlfgpasvvsgslsTDRERQIAQVFQPSHSL------P 322
EFJ30093     258 -AQP----------ITCAtfaqdviegranisdghq--hshqplfgpaslvgssitTERERLAAQVFQPSHSL------P 318
XP_005849467 260 ---Pdllrqlhaa-----------------------------------agglagagARREQLAAGVFRPGHVQ------P 295
XP_002504031 306 sVPPelmeslrrmy---------------------------------gtgvaggsaRSAERIRSEVFRPSHVL------P 346
XP_003054916 287 -VPPevlaamrarlg-------------------------------lgpgaggindRDRDRIARDVFRPSHIL------P 328
EPE05987     407 TMSIDEYLDEEFRRgnVIEGGGAQSGLVPEP-----------------DEDN-----YEKGD-AETMKARAWDEFTESNA 463
Q57XV0       327 TMTLAEFADAEMA---DVQRRMEANADAQRLqq--------------eEDELl---gPEGVEeRQRKRDSALADWKDDHP 386 Trypanosoma brucei
Q4DEG1       324 TMTLQEFAEAEMA---DVQRRMDASAAAKRQqe--------------eEDERl---gPDGVEeRQRQRDTRLADWKEDHP 383 Trypanosoma cruzi
XP_002880896 323 TMCIEDAGLTEMN---IMNDWQEQTKKAIEEattswyndkplrrkeedEEDD-------DEDeEAVMKARAFDDWKDDNP 392
XP_010316147 324 TMSIEEAGLTEMN---MMNEWQERNVKLMEEatsswyndgpktrpnedDEED-------DNDdAAQEKARAWDDWKDDNP 393
EDQ72779     323 SMSIEQAGLAEMK---IMRTWNETNQKIFDEarqsswv---geekkddDDSD---------DeAATNKARAWDDWKDDNP 387
EFJ30093     319 SMSIEQAGLKEME---MMRKWQEGNQQLQQEskstwl------eeeskDGSD---------DeAEESKQRAWDDWKDENP 380
XP_005849467 296 TMSVEQFGELE-----MVEQQRREAAAKERHe------------------rQqaarrAEDVEeEQVQQQRAWDDFKDDNP 352
XP_002504031 347 TMTVEQAGEIEHRE--MMERQRAQAENAARRa------------------rEesemtQEEREeRDLAKARSWDEFKDDNP 406
XP_003054916 329 TMTVEEAGEMEYRE--LMERTARQAANAKAAa------------------eEeakltEDEREaRELARTRAFDEFKDDNP 388
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