Conserved Protein Domain Family
TIP41

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pfam04176: TIP41 
TIP41-like family
The TOR signalling pathway activates a cell-growth program in response to nutrients. TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway.
Statistics
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PSSM-Id: 461208
Aligned: 132 rows
Threshold Bit Score: 184.237
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFN57235      64 FGDNYLHLTHEasgttISFTARDALQgwlddtsgaaaagsSISPA------------AAPAAGSAAPAH----------- 120
CCA72822      56 FGHNLIRLKHResgweYQFDTLHALQ--------------HVKNGpledg---dgavKVRYADEWLKSRtdpnsqt---- 114
EKD00708     134 FGHNSLVLQHPlv--tLSFDTLGALR--------------AVPVGegweer-cgggvLVSMADAWKNRKved-------- 188
Q5KA94        98 asryiaVSTEArv--nLSFKTLDALA--------------GVATGegwedr-vgggvLVSMAEKWGKNKswattestslp 160 Cryptococcus ne...
EIM19777      45 FLDSFVELRDNdsdfkISFNTRDALR--------------GVSKKne---------lRVSYADHWANSRqtee------- 94 
XP_009268839  45 FLSSGVEVLDTdsgfkLSFNARDALR--------------GVSKQne---------lRVSYADHWRSSRqphe------- 94 
XP_009269441  48 YPHNQIRIAHKlsnftLGFYARPALN--------------LVDKSgae-------akRVAYALHEGTKLqlq-------- 98 
KDE08447      59 FGNNRLTLTHHptnlkIECNCLDALK--------------AVASStq---------vKVAHAAEWSKAQes--------- 106
EGU13280      54 FGNNALSVRHEasgfaLEWNMLDMLK--------------AVKKGegwdaqpgsgavRVAHADEWSRGQaasg------- 112
EGG02764      69 FGQNRLEITHSasgfkYNFNTLSALL--------------LVDPTegse----gehlKVAYADHWSNSRkp--------- 121
EFN57235     121 ----------AAQT---LEYDWTYTTAYAGTVntgsggaagaagsdppkaaappasapagaagaaagaaagaaadgpcag 187
CCA72822     115 ---plpqtvpTK------PYDWTYTTMYEGHI------------------------------------------------ 137
EKD00708     189 --------vaAKPV---RPHDWTFSTCFNGST------------------------------------------------ 209
Q5KA94       161 aagvfdvpvpSKPV---KPHDWTYSTCYAGSV------------------------------------------------ 189 Cryptococcus ne...
EIM19777      95 -------sstIKPS---QPWDWTYTTRYNGSTsnvfst------------------------------------------ 122
XP_009268839  95 -------astIQPS---QPWDWTYSTTYSGST------------------------------------------------ 116
XP_009269441  99 --------------lpdKNYDWTYTTTYSGSStrsfentpytsntatp------------------lldddnnvdhstgg 146
KDE08447     107 --------ssHSDVtvqKPYDWTYTSLHPGTI------------------------------------------------ 130
EGU13280     113 ------satrLKVQ---KPFDWTYTTLHRGTT------------------------------------------------ 135
EGG02764     122 ---------tDAVTkviNPFDWTYTTNYIGTD------------------------------------------------ 144
EFN57235     188 gpTGAGRWEATTA--------------------QVNRALLT-SRD-P----ILYYDELALYESELDDHGSSRLALKVRVM 241
CCA72822     138 ---------SNEEglrypfi------ktqdplhAIPMAELQ-RHD-P----ILFYAQTLLFEDELHDNGSSSLLVRLRVM 196
EKD00708     210 ---------SSSSeptadasrltaqqftpsdthAIPLQLLA-RQD-PvldrILFYDDVPLYEDELHDHGGSELNVRVRVM 278
Q5KA94       190 ---------AGPStfep------------ssthSLPLSLLA-RQD-PvldqILYYEDVPLYEDELHDNGESILNARIRVM 246 Cryptococcus ne...
EIM19777     123 ----snnvnDT-----------------------IPIDKLSdTNQ-P----ILFYDDVQLYEDELGDNGQVGLNVKIRVM 170
XP_009268839 117 ---------ESERahwqpi---------ptttpVIPIDKLSdTTQ-P----ILFYDDVQLYEDELGDNGQVGLNVKIRVM 173
XP_009269441 147 nsNHDYDNNHSHH-----------------------------DSD-P----TAIRNTITFFQDSMDGAGYTTLTATLRVD 192
KDE08447     131 ---------STTStarpeft------papeghpGIPLHLLA-RQDiP----ILFFDEVPLFEDELGDNGTAELVVRVRVN 190
EGU13280     136 ---------SPAStsaapaqae--wqhappthpGIPLPLLA-RTDiP----ILFFDEIALFEDELGDNGIADVTVRVRVN 199
EGG02764     145 ---------ESAKnlfkrpd-------dvenhpGIPLAVLS-RPD-P----ILFFDEVTLFEDELHDNGMASLQVKVRVM 202
EFN57235     242 PRCWYVLLRFWLRVDHVMVRLRETRLFCQFDSPeg-------taTVLREVQVRY 288
CCA72822     197 PGCIFLLSRFTLRVDQVLFRAFDTRIYHSFSSSp---------pLVIKEVIGLE 241
EKD00708     279 PHAFFVLARLFVRVDAVVFRIFDTRVFHSFGSN-----------EVVRESSGME 321
Q5KA94       247 PHSFFILARLFVRVDNVLFRIYDVRIYHAFGSD-----------EIIREVSGME 289 Cryptococcus neoformans
EIM19777     171 PFGWFILQRLFLRVDKVLFRMFDVRVYHEFNSG-----------VVIRESTGLE 213
XP_009268839 174 PFAWFILQRFFLRVDDVLFRMYDVRVYHDFSGN-----------VVSRECAGWE 216
XP_009269441 193 DDGFQVLQRHYVRIDRILFRMYETTFTHKFGTW-----------KIEKRCKGWE 235
KDE08447     191 SFSIFVLSRLFIRVDHVLFRIFDVRTYVPLTTPpsphsesiiplEIIQELKGRQ 244
EGU13280     200 HFSFFILSRFSLRIDGVLFRHFDVRVFHRFGTD-----------EIIREVKGRE 242
EGG02764     203 PSCIFVLSRFFLRVDGVIFRVFDVRLFIDITKN-----------QIIREVKGKE 245
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