Conserved Protein Domain Family
Mucin

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pfam01456: Mucin 
Mucin-like glycoprotein
This family of trypanosomal proteins resemble vertebrate mucins. The protein consists of three regions. The N and C terminii are conserved between all members of the family, whereas the central region is not well conserved and contains a large number of threonine residues which can be glycosylated. Indirect evidence suggested that these genes might encode the core protein of parasite mucins, glycoproteins that were proposed to be involved in the interaction with, and invasion of, mammalian host cells. This family contains an N-terminal signal peptide.
Statistics
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PSSM-Id: 250634
Aligned: 6 rows
Threshold Bit Score: 44.8537
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q26879   1 MMt----TCRLLCALLVLVLCCCPSVCIKANGvdeqvapdmtkvpgaqlpvkkeveqgrgvekplivtgkeeaqgtvsgg 76  Trypanosoma cruzi
O61019   1 MTtltmvTCRLLYALLMLALCCCPSVCVTASG------------------------------------------------ 32  Trypanosoma cruzi
O61046   1 MT-----TCRLLCALLVLALCCCLSVCVTANG------------------------------------------------ 27  Trypanosoma cruzi
Q9NIQ5   1 MM-----LRRVLC-VLVFAL-CCACVCATAQEe----------------------------------------------g 27  Trypanosoma cruzi
Q9NIQ2   1 M------LRPVLC-VLFFAL-CCACVCATAQEe----------------------------------------------g 26  Trypanosoma cruzi
Q9NIQ3   1 MM-----LRRVLC-VLFLAL-CCACVCATAQEe----------------------------------------------g 27  Trypanosoma cruzi
Q26879  77 ASNNQGASGASGQSQLQSPSVPLQPPTAPTVTSwaqsgpilpekeqeketTASTTITTKTTKAPTTTTTTTTTTAAPEAP 156 Trypanosoma cruzi
O61019  33 QKQETTTTTTTTKPPTTTTTTTTKPPTTTTTTTtk-------------ppTTTTTTTTTTTTTTTTTTTTTTTTTAPEAP 99  Trypanosoma cruzi
O61046  28 ---------KEGESSSTTTTTTTKPPTTTTTTT--------------------------------TTTTTTTTTTTTEAP 66  Trypanosoma cruzi
Q9NIQ5  28 QYDAAVFEAAGGDPKKNTTTTTTTSTATSKAPK----------------------------------------------- 60  Trypanosoma cruzi
Q9NIQ2  27 QYDAADVEAGDGPDKTTTTTTTTTTTTTTTTTT-----------------TTTNA----PAKSTTTTNAPAKSTTTTNAP 85  Trypanosoma cruzi
Q9NIQ3  28 QYDVAVVEAGEGQDQ-TTTTTTTTTTTTTTTTT-----------------TNAPAKDTTTTTTTNAPAKDTTTTTTTNAP 89  Trypanosoma cruzi
Q26879 157 SdaVNSAEAPTTTTTRAPSRLREVDGSLSSSAWVCAPLLLAASALAYT--AVG 207 Trypanosoma cruzi
O61019 100 S--ITTTEAPNTTXTRAPSSIRRIDGSLGSSAWACAPLLLAASALAYT--TLG 148 Trypanosoma cruzi
O61046  67 T--ITTTEAPTTTTTREPSSIHKIDGSLSSSAWVCAPLVPAVSALAYT--TLG 115 Trypanosoma cruzi
Q9NIQ5  61 NttTTTSKAPTPEDAR----------SPGGPVWVPVPLLLLVSAAVATagAAC 103 Trypanosoma cruzi
Q9NIQ2  86 AknTTASKAPTPGDGS----------SLGGPLWVQVPLLLLVIAAVATagAAC 128 Trypanosoma cruzi
Q9NIQ3  90 AknTTTSKAPTPGDGS----------GLGGPLWVQVPLLLLVSAAVATagAAC 132 Trypanosoma cruzi
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