2L5S


Conserved Protein Domain Family
Activin_recp

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pfam01064: Activin_recp 
Activin types I and II receptor domain
This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box.
Statistics
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PSSM-Id: 460048
Aligned: 16 rows
Threshold Bit Score: 29.3904
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2L5S_A     6 LQC-----F-------CHL------CTKDN------FTCVTD--GLCFVSVTEt--------------TDKVIhn-smCI 44 
P70539    26 LKC-----V-------CLL------CDSSN------FTCQTE--GACWASVML---------------TNGKE-----QV 59  Norway rat
Q95SI0    15 LTC-----Y-------CDGs-----CPDNVs----nGTCETRpgGSCFSAVQQly-----------deTTGMYe---eER 59  fruit fly
O00238    30 LRC-----K-------CHHh-----CPEDSv----nNICSTD--GYCFTMIEEd--------------DSGLP-----VV 67  human
EKC26965  31 LKC-----R-------CSP------CHPNAv----nDTCIAK--FQCFTGLRLv-------------vENGEQv---eII 70 
Q04771    33 YMC-----V-------CEGl----sCGNED-------HCEGQ---QCFSSLSI---------------NDGFH-----VY 66  human
Q7QJY6    30 YKC-----Ys------CEPp----dCADTAih---aHYCQNA--IQCWKSRTRd--------------PEGNE-----NV 70  Anopheles gambiae s...
Q8K1T6    28 LRC-----YtcsfakpCDPvp--reCREDEvcgvsvGTSGRTlvRWPFSRWLLsflpmaaaatsaflfCPTEQkeeevIE 100 house mouse
Q24468    34 IECehfdeKm------CNTtq---qCETRIe----hCKMEADkfPSCYVLWSVn-------------eTTGILr----IK 83  fruit fly
AAB22240  49 RECi----Y-------YNAnwelekTNQSGve---sCEGEKDkrLHCYASWRN---------------NSGFIe----LV 95  African clawed frog
2L5S_A    45 AEIDLIPRD--RPFVCAPSSKTGsv---------------tTTYCC-NQDHCNKIE 82 
P70539    60 SKSCVSLPElnAQVFCHSSNNVT------------------KTECC-FTDFCNNIT 96  Norway rat
Q95SI0    60 TYGCMPPEDngGFLMCKVAAVPHlh--------------gkNIVCCdKEDFCNRDL 101 fruit fly
O00238    68 TSGCLGLEg--SDFQCRDTPIPHqr---------------rSIECCtERNECNKDL 106 human
EKC26965  71 SKGCMSEEEn-SILQCKGHLVPHrl--------------prTVECCnDEDYCNDFL 111
Q04771    67 QKGCFQVYEq-GKMTCKTPPSPGq-----------------AVECC-QGDWCNRNI 103 human
Q7QJY6    71 QRGCTTEHEq-LPLYCSQNQKPNtgdsggpkkrhvsstgmyNIECC-TGDYCNNGS 124 Anopheles gambiae str. PEST
Q8K1T6   101 RKGCLPRAq--CPLLGHATYWSRsy--------------slRHQCC-EQDLCNAAA 139 house mouse
Q24468    84 MKGCFTDMHecNQTECVTSAEPRqg--------------niHFCCC-KGSRCNSNQ 124 fruit fly
AAB22240  96 KKGCWLDD-----FNCYD-----------------------RQECIaKEENPQVFF 123 African clawed frog
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