3EWU,1VQT,1DBT,3RU6,3LDV,1EIX,3IEB,1SO4,3AJX,4LUI,4MUZ,1KM1,2CZ5,1DQW


Conserved Protein Domain Family
OMPdecase

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pfam00215: OMPdecase 
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Orotidine 5'-phosphate decarboxylase / HUMPS family
This family includes Orotidine 5'-phosphate decarboxylase enzymes EC:4.1.1.23 that are involved in the final step of pyrimidine biosynthesis. The family also includes enzymes such as hexulose-6-phosphate synthase. This family appears to be distantly related to pfam00834.
Statistics
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PSSM-Id: 395160
Aligned: 87 rows
Threshold Bit Score: 107.735
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3EWU_B  32 TNLCLSADVSLA---RELLQLADALGP-SICMLKTHVDILNDFTldvmKELITLAKCHE--FLIFENRKFADIGNTVKKQ 105 human
Q97M04   1 MKVQLALDRMTI---DEAKSITEEVYD-YIDIIEVGTSLIKDYG----KKSISSMRDEFkdKLILADIKTCDEGEYEFKA 72  Clostridium acetobuty...
O29400   4 PILQVALDLLEL---KRAIEIAGEAIEgGADWLEAGTPLIKSEG----MNAIRELKKHYrgHKVLADMKTIDTGAIEVEM 76  Archaeoglobus fulgidus
Q9UX10   4 SRVILAMDKPLS------YQVLKEMEN-ELYGIKVGLPLVLDLG----VDKTRELLIGLdvEEIIVDFKLADIGYIMKSI 72  Saccharolobus solfata...
Q9Y9D9  11 KRVIVALDPARRgdvDRLLDMARLVCG-VGAGIKVGLPMLALGGs---EALAEAARLCKggGLRVLDLKLADIGYIMRLA 86  Aeropyrum pernix K1
4LUI_A  22 PKLMLALDVLDR---DRALKIVEDVKD-YVDAIKVGYPLVLSTG----TEIIKEIKKLCn-KEVIADFKVADIPATNEKI 92  Methanocaldococcus ja...
4MUZ_B  22 KQLILALDVMDG---EKAMEIAKKVAE-HVDRIKVNYPLVLSAG----VGIMKRLSEIK---PVIADFKIADVPYTSSLI 90  Archaeoglobus fulgidus
O74110   4 SRLVVALDLTDK---DRALEIARSIGR-QVFAIKINWPLVLAGS----GSIIGEIARVS---RVVCDFKIADIPNTNSII 72  Thermoplasma acidophi...
Q97CS3   3 KRIIVALDVKEK---KKAIDIAESLSD-IVFAFKINWPLVLYSS----PEVIGEISQYG---KVICDFKVADIPYTNSLI 71  Thermoplasma volcaniu...
1KM1_A  13 NRLILAMDLMNR---DDALRVTGEVRE-YIDTVKIGYPLVLSEG----MDIIAEFRKRFg-CRIIADFKVADIPETNEKI 83  Methanothermobacter t...
3EWU_B 106 YEggiFKIASWADLVNAHVVPG-SGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGD------YTRAAVRMAEEHS--EF 176 human
Q97M04  73 AY------EAGADIATVMGTSP-FETIEICYKVSKEYK-KHMMIDLMETDDRKIQQLkt--ceDAILFLHLPKDSEn--- 139 Clostridium acetobuty...
O29400  77 A------AKSGADIVIILALSD-DDTIAEAIRAARKYG-CEVMADLINVPDPASRAKeveelgVDYLNVHVGIDQQm--- 145 Archaeoglobus fulgidus
Q9UX10  73 VE-----RLSFANSFIAHSFIGvKGSLDELKRYLDANSKNLYLVAVMSHEGWSTLFA--------DYIKNVIREISp--- 136 Saccharolobus solfata...
Q9Y9D9  87 AEs----LSRGFDAAIAHAFVGyEGGLVELKKTLDGLGARLVLVVSMSHPGSREVLD---------PCLDKLLAVArrVE 153 Aeropyrum pernix K1
4LUI_A  93 AK---ITLKY-ADGIIVHGFVG-EDSVKAVQDVAKKLNkKVIMVTEMSHPGAVQFLQ---------PIADKLSEMAkkLK 158 Methanocaldococcus ja...
4MUZ_B  91 AR---IAFENSAESVIVHGFVG-SDTLREVCRVAEEFGgKVYAVTELSSPGGEEFMS---------AVSLKIVEKAkeAG 157 Archaeoglobus fulgidus
O74110  73 AK---FARDQGAWGIISHSFTG-LESLRSVVE--ASGDtKVFSVVAMSHPGS-DLIN---------DNYRKLMDISerAG 136 Thermoplasma acidophi...
Q97CS3  72 TE---RVRDLGAWGIISHSFLG-EESLKSVVN--AAKGmHVFSVVAMSHPGS-DMIN---------SNAMQLMKLSieCG 135 Thermoplasma volcaniu...
1KM1_A  84 CR---ATFKAGADAIIVHGFPG-ADSVRACLNVAEEMGrEVFLLTEMAHPGAEMFIQ---------GAADEIARMGvdLG 150 Methanothermobacter t...
3EWU_B 177 VVGFISGsrvsmkpEFLHLTPGVQLe----AGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMY 246 human
Q97M04 140 ---kSLLdm---fqSKKQLFKDVK------RIAVGGGISEKVMPGITLIN-PEIVVVGSFITKSKNLSAAAREV 200 Clostridium acetobutylicum
O29400 146 -kGLDPLev---lkDVVDSVSIP--------VAAAGGLDAERAAACVSMG-ASIVIVGSNIVKSRNVTESARKV 206 Archaeoglobus fulgidus
Q9UX10 137 -kGIVVGgtk--ldHITQYRRDFEKm---tIVSPGMGSQG-GSYGDAVCAGADYEIIGRSIYNAGNPLTALRTI 203 Saccharolobus solfataricus P2
Q9Y9D9 154 PWGVVAPatr--peVVARVRETLPTt---vILSPGVGAQGGKPGDAICLGGADYEIVGRMVAGSPDPVSALRGV 222 Aeropyrum pernix K1
4LUI_A 159 VDAIVAPstr--peRLKEIKEIAELpv--iTPGVGAQGGKIEDILNILDE-NDYVIVGRAIYQSQNPKEEAKKY 227 Methanocaldococcus jannasch...
4MUZ_B 158 CHGLIAPstr--ieRLREIRKAAGDme-ilCPGIGAQKG----SIEAVKY-ADGIIVGRGIYASGNPAEEARKL 223 Archaeoglobus fulgidus
O74110 137 VYGYIAPgnk--lsDLSEIRKRTKKti--mSPGIGSQGG---RASDAIKAGADLVIVGRSIYESADPVTAAEAI 203 Thermoplasma acidophilum DS...
Q97CS3 136 VYGFVAPank--idDLRMIRSATDRvi--iSPGIGAQGG---DPYTAVLNGSDYLIVGRSVYESDKPELEVSKL 202 Thermoplasma volcanium GSS1
1KM1_A 151 VKNYVGPstr--peRLSRLREIIGQdsfliSPGVGAQGG---DPGETLRF-ADAIIVGRSIYLADNPAAAAAGI 218 Methanothermobacter thermau...
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