1XTL,1PZS,6VBS,3L9E


Conserved Protein Domain Family
Sod_Cu

?
pfam00080: Sod_Cu 
Copper/zinc superoxide dismutase (SODC)
superoxide dismutases (SODs) catalyze the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the human SOD1 gene cause familial amyotrophic lateral sclerosis (Lou Gehrig's disease). Structure is an eight-stranded beta sandwich, similar to the immunoglobulin fold.
Statistics
?
PSSM-Id: 459663
Aligned: 398 rows
Threshold Bit Score: 49.867
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
1XTL_C         34 V-GFIEIKes--dDE-------Gld-ihISAN--SLRp--G-ASlGFHIY----EK------G---SCvrpdFE------ 78   Bacillus subt...
CCG84096      124 PyGFIEFVytsetSAr------------IEVRltNMPe--DrGPfSYHIHtdrvSEhitdppE---QCk----------- 175 
EHA18006       52 VrGSVTIFpkpdsVGv-----------lVSAQfwGIPd--NdQQlVYHIH----QKpvp-qdG---NCy----------- 99  
XP_003890229   58 VsGQIHFAlqpesNAv-----------aVSISinGLNalnStAAyAYHIH----TNpis-sdG---NCa----------- 107 
KEI40921       95 IeGRVl---------------------------rGLNd--StEY-RYHIH----TNpis-adG---NCa----------- 125 
XP_001382774   46 VtGTVSFSaaqngSv------------lVSVDlsGLPs--TgGPfPYHVH----EHpvp-tdG---NCt----------- 92  
EFN70893      729 VyGYIKMTqlvykDGsqsetviEvnlrhPGKHdrNITk--N-HNwAIYVN----PV------G---------VDatvkvk 786 
ETN65975      847 AyGYIRFTqlignDNsqsdttiEvklryPGKHdrNVTh--N-HSwNIWVN----PV------G---------VDatvpqv 904 
XP_002619633   74 TkGYVIMTstngvSAn------------VHVDlvDLPq--EgGPfTYHIH----EFa----vGsdnTCd----------- 120 
XP_321476     854 AyGYIRFTqlignDNsqsdtiiEvklryPGKHdrNVTh--N-HNwHIWVN----PV------G---------VDatvqqv 911  Anopheles gam...
1XTL_C         79 ----SA-GGHFNP-LN--------K-----EHGfnnp-------------mghHaGDLP-NL--EvGADGKVDVI-MNAP 122  Bacillus subt...
CCG84096      176 ----AA-KGHLDPaNVgeafvcdsEkkggcQAGdlt---------------gkY-GKIPaSIk-----sSQVYKEvYDEK 229 
EHA18006      100 ----ST-GAHLDPyGRgdatpcdiNapqtcQVGdls---------------gkH-GPIW-------APDNEVFSTtYTDW 151 
XP_003890229  108 ----SA-LGHLDPlNVtdglvcnpQisqycQEGdls---------------srH-GKFNgS--------ESTLNLaYIDD 158 
KEI40921      126 ----SA-LGHLDPvSVtdyiacdpSqpwycQEGdls---------------gkH-GKLQgTVn------GNTPAFsFIDP 178 
XP_001382774   93 ----GT-LAHLNPfGGsv----naTdaagkEVGdla---------------gkH-GNIE----------GQSADLsYVDD 137 
EFN70893      787 dtrcVAgGYMWNPyFT--------------QLAdplnddlyrqecgpdlplrcyvGDISaRVgpIn--iGEKRQV-FTDQ 849 
ETN65975      905 etrcVAaGYVWNPyYT--------------QLAdplnhdlyrrecgpdnplrcyvGDVSaRLgpIs--iGSRRQV-FTDS 967 
XP_002619633  121 ----TT-GPVFNPySSsde--cpeEdqnecAVGnla---------------gkH-GALE----------GTCFETdFVDP 167 
XP_321476     912 etrcVAaGYVWNPyYT--------------QLAdplnvklykqecgpdnplrcyvGDVGaRLgpIs--iGSRRQV-FTDS 974  Anopheles gam...
1XTL_C        123 DTSLKkgsklnildeDGSAFIIHEQADDYltnpsgnsgARIVCGAL 168  Bacillus subtilis
CCG84096      230 YISWKasda---nffVNRSIVIHEASNK----------GRIACANI 262 
EHA18006      152 FLSNVegep---affGNLSLVVHAADN-----------SRLACGNF 183 
XP_003890229  159 YLRFWpqp----fsiLGRSVVVHLPNS-----------TRIACGNI 189 
KEI40921      179 YVRFYpqp----fsiLGRSVVIHAPDL-----------TRVTCGNI 209 
XP_001382774  138 YLSLNpdnk---ayiGGLSVVVHLLDN-----------TRIACANI 169 
EFN70893      850 NFPLGgsv-----saIGRSIVIYDKDFAS---------NRFACANI 881 
ETN65975      968 NFPLEgtv-----saLGRSIVIFGPDFSG---------HRFACANI 999 
XP_002619633  168 FLSLNptsr---nyvVGRALVIHYADG-----------SPLACATI 199 
XP_321476     975 NFPLEgtv-----saLGRSIVIFGAEFSG---------HRFACAKI 1006 Anopheles gambiae str. PEST
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap