Conserved Protein Domain Family
CAS_csx29_CRASP

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NF041237: CAS_csx29_CRASP 
type III-E CRISPR-associated TPR-CHAT protein Csx29
Csx29, the protease subunit of the craspase complex, is a TPR-CHAP family protein of type III-E CRISPR/Cas systems. Craspase is guided by crRNA, but cleaves protein, not nucleotide, and therefore is highly interesting for potential technological applications.
Statistics
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PSSM-Id: 469139
Aligned: 17 rows
Threshold Bit Score: -1
Created: 25-Apr-2023
Updated: 4-May-2023
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_124327588      96 RRETLEQIIRFLQNGAEEKD------------ADDLLLKTLARAYFHRGLLYRPK--GFSVPARKVEAMKKAIAYCEIIL 161 Desulfonema...
9_ncbifamImport    1 RSEWIELALRHLLALFEPDSrgqqvwphqaivPLPEAVVLAGRCYLHRGLAFLPQgrNPAELGDRRDFLEAGMRLVATAV 80 
RLC08521         141 RHHVLETAIHRISALMDKDKehwp----fpepEEPKVWAFLAQAYFERSRTILPK--GADFPQKKVEGLRKARIWAEKIK 214
10_ncbifamImport   1 RKEMIESALRLLMGLYKDRHe----------kLQPRTFVLIAKAYLLRSLITRPK--GITIPEKKKEALKKGIGFVESAI 68 
5_ncbifamImport    1 MKKKTDDALKILFAFYKEKRg----------nVSPETLILIAEAYYLASVAILPK--GITIPEKKKEALSKGIEFINRAI 68 
KKO18796         110 QRELLESALKILVNFEKEMDg----------kIEPATCALIARTYLLRSAIMLPK--GFTVPEKKKEALRKGSEYIRtid 177
7_ncbifamImport    1 RVRSLENALKLLFDFYGKQKne--------qsISTAVLVLIARACYERSVLILSRq-DKIMLEKKKRIIKKGIEFAKev- 70 
WP_207678643     101 VSNELKGDIQKLENNVKESGkdseel-nktreKHGEILADMGRAYLHRAKIIRPK--GFTIPAKKKESLRKALDFCKEAK 177 Desulfonema...
4_ncbifamImport    1 ALSGVLDNLLELRQDINPTQkiqtidyaafakHLDKIHYLMSMAYLGLARLVPVK--AISVSQKKIEALKEALRWLNEIK 78 
8_ncbifamImport    1 YARAVEALIRLLKTVEKTP----------------ELCVVLAELLIQRAKLLNPK--GFGANPKKAKMLREAVALLDEAI 62 
WP_124327588     162 D-----------------------------------------------------KNEEESEALRIWLYAAMELRRCG--- 185 Desulfonema...
9_ncbifamImport   81 Dsagn---------------------------------------------gpdyNQPDQLPRAVLHALLLHELQRLSpsg 115
RLC08521         215 D--------------------------------------------------------GNKNVLLLLSQIYLETQRVAgde 238
10_ncbifamImport  69 Kkiqssen----------------------------------------ilshssDIDLLEKAWRIKSQLYLEYYRVNkde 108
5_ncbifamImport   69 RaidllknsspatvsteeassqarsnsstgaehltpsppaktnsssraeinsssRAESREEAFRIKSLLSIEKNRIDrhn 148
KKO18796         178 ---------------------------------------------------dltEEALRVRGSLLLEQRHIDILEKNres 206
7_ncbifamImport   71 ----------------------------------------------------vfIESNNKEALRLHCILLLELEKIDkdd 98 
WP_207678643     178 Ar-----------------------------------------------------HLAGLVGLEMDRCDMSDFDSENsle 204 Desulfonema...
4_ncbifamImport   79 D--------------------------------------------------------GSNDSVALRIEIGLELLWLGkqs 102
8_ncbifamImport   63 Kn-----------------------------------------------------KEKLSYAYRLKVSAYYELKREPsda 89 
WP_124327588     186 ---EEYPENFAEKLFYLANdg-fISELYDIRLFLEYTEREE-----DnnfLDMILQENQDRER-------------LFEL 243 Desulfonema...
9_ncbifamImport  116 vysQELSDLLETIQIVLSG----KATLDPEEIFLLWLQGRVnqastT---ANEWRQIGEAVAAcp---------wsGGRD 179
RLC08521         239 -isEKVIKDILFECVCELSadsmTRDEMDICLHLFEKDQDS----------RDIHYLETIMAS-------------DSDA 294
10_ncbifamImport 109 -cdKNTLKEVLENSLISGCdk-fDKNIEDVQIAIRYCELE----------SSR-EYLEQIISShl---------egIEFE 166
5_ncbifamImport  149 -cdDDTLKNILKEAVANGCck-yNEKKEDVLIAVRLCELGE---------NVAVETHCHASPIkl---------ndIKAN 208
KKO18796         207 ngdNQTLIKELREALENGCdk-fNNTIEDVRIALCYIELT----------DDKTDLLQKIIDSql------------dFP 263
7_ncbifamImport   99 -rdVSKLKEALSSAIQNGCke-fNEKAEDIEISLRFAEFVKkdgndEplsEKDIKSLTTIVGTnl---------htENIE 167
WP_207678643     205 kllRDATTGVSLSKDQYYSneyrKAEYYQMCIRLAEIEEDKhgatdEgseNNRYKRLEGILGPkksqgkkkgkknkKKKG 284 Desulfonema...
4_ncbifamImport  103 idlEEMALLLDENMFAESQa------gRQLVLYLAESEIDKs-------------YINQIIKS---------------DE 148
8_ncbifamImport   90 -gvPDNYYEVLEEALRRNKerinEPEFELAAIELAESER------------TDVQELLVKIGSns----------kdNTH 146
WP_124327588     244 CLYKARACFHLNQLN-DVRIYGESAIDNAPGA----------FADPFWDELVEFIRMLRNKKSELWKEIAIKAWDKCREK 312 Desulfonema...
9_ncbifamImport  180 ARYRLHLPLIGAWANwRASGTLENANRQAVLAalq----khqLYSPLWEEAVAFLRELKDKSCTDWSDFAYQVWRLCRDR 255
RLC08521         295 PSFFKARAAFLKGDKqKVGSELRATLKFLKSTp---------FSHPVWEWCADFLVNLSKEEFPGWQDLAYETWKVCRNL 365
10_ncbifamImport 167 KARAYKLLELENENEdEIRKSMKVVIEEYLSG----------FSDPLWEDAVEFINKLKSDNKNCWKELSLDMYKVCREQ 236
5_ncbifamImport  209 YLQRTKLYYFLNKDNdNTLKYMNKCINLLKYRy---------LSHRLWDETVGFIERLMLDKSSLWKNFALGAYEACRKQ 279
KKO18796         264 GIELYRLKAYFLKGDyAAISDEALKEELSGIR----------FNHPVWNEAMIFIKQLKDAQADCWRKLALAAYQVCRTR 333
7_ncbifamImport  168 LKKAKAYYLMGNKENdVKIVECMKTFAKKLESl--------sFSDPGWSKAARFVIELEKTGKDCWKKIALLVWEACKKR 239
WP_207678643     285 TNSKSALEKIMAFEKfKVAVYLGEGKEKTHWNdfseflmrypFSHPSWEDSVRFLRRLYKKGNDKWRELSVALWEIAKKN 364 Desulfonema...
4_ncbifamImport  149 AKPLEKARAALILNDyNISKYTNDALEIAAKKg---------FQDRDWDELTNFIIRLARSNHSDWKHLARKAWEKCAHR 219
8_ncbifamImport  147 RSMAFSLLNQREKAKeHFDKALNETAELARKGil-------sFTHPVWEKLHHAAELLDGD-----RDAAVSLWKTLKGF 214
WP_124327588     313 EMKV-GNNIYLSWYWA---RQRELYDLAFMAQDGIEKK--------------TRIADSLKSRTTLRIQELNELRKD---- 370 Desulfonema...
9_ncbifamImport  256 EKEF-GFGFQIRQYWA---RLDELYRLVIGAMVEQGEVek-----------aAEVVDSLKARTTLTWRDMEGLLAGrs-- 318
RLC08521         366 EKKS-FKGHILRWYWS---RLGQLYDTAFTAVIEKAGAsqndkdrmywlwtaAEIADSLKSLPTVRWMAVENDEALfqqe 441
10_ncbifamImport 237 EAE--TASLHLRWYWS---RQRRLYDLAFIAADKEEEK--------------AKIADSLKSRLSLRWSALEETGKKskn- 296
5_ncbifamImport  280 ESK--TGILRLRWYWS---RRGDLYDMAFLAAKKNGDKmr-----------mAEISDSLKSRTSLRLSALQKIKGEdn-- 341
KKO18796         334 ESE--TSSLHLRWYWS---GYRLLYDLAFIAEDDLHRK--------------AEIADSLKSRVSLHAKALDEIIKNdke- 393
7_ncbifamImport  240 YEE--STSVEHYWYFGhlmTHYYIADLAFAAQDDIEKK--------------VEIADFLKSKILLHGQSLDDEAERffe- 302
WP_207678643     365 SAK--TSSIHLRWYWS---RQRDLYDLAFLSALEQADIaedesvrqeklrlaAKVADSAKNRPALTWQAMEQMADKd--- 436 Desulfonema...
4_ncbifamImport  220 ESIT-LNNLYLRQFWA---KQRDLYDLAFHATEDSPKK--------------IEIIDKLKSRPALRHSAIEKISQQn--- 278
8_ncbifamImport  215 ENTRrYHGLHLLWYWS---RLTDIYSLAFRRAYDDGDYlt-----------aFWVADGLKARPLIQWQVLEHVFRKe--- 277
WP_124327588     371 --AHRKQNRRLEDKLDRIIEQENEARDGAYLRRNPPCf-tGgKREEIPFARLPQNWIAVHFYLNELESheg-gkGGHALI 446 Desulfonema...
9_ncbifamImport  319 gtAEKCREAYYAMEAQAAMGVYAERLLDDDCRRLMQT---AvAPTGRPLAKVPTGWVAVHFHLDETRG------QAFLIG 389
RLC08521         442 keDKEGKEEWFENETRSIEDRYLINLNQGYSNPVPVP-------PPKPFSELPEPWLAVHFYVEENGQ-------GHALI 507
10_ncbifamImport 297 krEKEEISRILEAEAVAMLGGYIKGARKILKKRRRPLpdeQ--------RSIPKDWIVIHFYVNQLEN------KCYALI 362
5_ncbifamImport  342 -----rIKEFYDNIEKNYTNSYVKGSTDEAELSEEIGkkp---pekIDYTNVPKGWVVIHFYLNQLEG------MGYAIL 407
KKO18796         394 reE------YYNAHAVAYAGGYVKGAGRIHTGRKEKDcdtNn-----VFKALPKDVAIVAFYLNYCEKnk--dsRGRGYA 460
7_ncbifamImport  303 ynKDVRQQHFIKGLEMVYKTEKNRTSGANRRG----------------FKEIPKDWVVIHFYLNKYET------KGYAIL 360
WP_207678643     437 ----eALKKEIENYAQALGGGYIEQFEKTELPKNTNP-------QDDIPDDLKTSGLVVQFYLVHLKDye----nGYALI 501 Desulfonema...
4_ncbifamImport  279 ----eGLRKLYDMESAIYGNYYYSQAEQAKWNGIARSy--LkLPAFPSLNMLPANWLSVHFYISTGATkketkdKGYAFV 352
8_ncbifamImport  278 -----gFEDYVEAEVYGRLGYYVRKSGGLKRRGTDSEfa----pFEPPPFKLKDGIAVVSLYLSEKEG--------YGLV 340
WP_124327588     447 YDPQKAek----------dQWQDKSFD-YKELHRKFLEWQENYILNEEG------SADFLVTLCREIEKAMPFLFKSEVI 509 Desulfonema...
9_ncbifamImport  390 APASVTekapsfdprpllaAWQIWRRH-YGQMPTEIEFDRQQLDVSLPKwe--seNGQHLLDLCHRMGEQFSFLFRLAVN 466
RLC08521         508 YDSLTK-------------CWEKEEAFdAAPLWEAYVSWRTSYSAGPQTerp-dfSETQMAELCKKLGENMGFLFDLPED 573
10_ncbifamImport 363 YNKDEN-------------TWKCEFVKeYQRLFHVFLTWQTNYNRCKe------rAADSLVQLCKEIGNAMPFLFDECII 423
5_ncbifamImport  408 YDKEAD-------------TWQYKDFP-YKELFNAFITWQTNYSLYKe------gAARYLVELCRTIGSAMPFLFENDFI 467
KKO18796         461 LIAENG-------------TWNIKEFP-FDSLYKAYLTWQTNYARHKe------sASPSLVELCEEIGRAMPFLFEITKK 520
7_ncbifamImport  361 AYKDR--------------VWEIKEFP-YVNLFEVFITWQTNYFVNKPKys--esTAIYLIELCKEIGRVMPFLFDVANK 423
WP_207678643     502 YDGKTK--------------KWSCEMFnFFPIWEKYLQWQSVYFDLPANqk--eeSADQLKALCLELGRHLYFLFDFEEN 565 Desulfonema...
4_ncbifamImport  353 TNSDGD--------------VLGVREFkSAPIWKAFQNWQDIYFTAHGNvgdysnLNKPLEVLCQTVGQELNFLFDNSLL 418
8_ncbifamImport  341 LEGSG---------------VKSTFRFdANPLWKIYLSYSEALSRGADv------LKHNIGTVCLEMGKAFGELFELDSD 399
WP_124327588     510 PED-----------RPVLWIPHGFLHRLPLHAAMKsgn-nsNIEIFWERHASRYLPAWHLFDPAPYsr------------ 565 Desulfonema...
9_ncbifamImport  467 EEI-----------KGLLFIPHGFLHQLPLHAAHK------DSEYLFGRLPSVFLPAWEMLPATLPstp----------- 518
RLC08521         574 DKP-----------RPVLFVPHRFLHMMPIHAACRn------GTYFFTQRPSLYLPAWSLTGFQPDepn----------- 625
10_ncbifamImport 424 PQD-----------KNVLFIPHDFLHRLPLHGAIHek----nnGVFLENHPCCYLPAWSFTAKENnavv----------- 477
5_ncbifamImport  468 PPE-----------KDVLFIPHDFLHRLPLHGAIKee----tnEVFLQKCACCYLPAWSFAEGSRAeqenadqscagqsl 532
KKO18796         521 R---------------IVFVPHDFLHRLPLHGAIKre----wpKVLLEEYSCLYLPAWSLLHADTtkss----------- 570
7_ncbifamImport  424 Q---------------VLFIAHDFLHRLPLHAAMKknaansIEEVFLKEHQCYYLPSWSFASKKDapv------------ 476
WP_207678643     566 RKAheknqdtakenWDMLFIPHDFLHRVPIHGAIKkn----gTNILLKKFNCTYFPTLPNASITPEspk----------- 630 Desulfonema...
4_ncbifamImport  419 PEG-----------RPVVFIPFDFMHKLPLHMAINsn-----gELWAKRNPCAYLPSWHLLHPPAVdskn---------- 472
8_ncbifamImport  400 KIKr------------LVIIPHGFLHLFPFHGAYSee----kGMYLLEKFDVSYLPSFELALKCFSd------------- 450
WP_124327588     566 ------------------------eeSSTLLKNFEEYD-----FQNLENGEIEVYAP----------SSPKKVKEAIREN 606 Desulfonema...
9_ncbifamImport  519 -----------------------grnDADSFASLRDYEhglvaAIKSAHSWNYFHGDihgpksplwaDIVARYGNGGNAI 575
RLC08521         626 -----------------------tsnIQMLYKSFDDDDyafdkLKIQGNWSKIKDPAsp------------sDVLTLDDS 670
10_ncbifamImport 478 -------------------------qgsILLKNFPEYS-----YEELVSNSTLWTSPvk-------dPASPDDLKTIIAS 520
5_ncbifamImport  533 deqsnaehipsaqyklrrsmeesavhKHVLLKNFEEHD-----QRYFKDVVTMDWDLkr-------iAASHEDLKKV-NS 599
KKO18796         571 ----------------------qtarKRMLIECFHEYD-----YHELQTKINAQIKEskgvvwekreKAKPKDLLQIPEA 623
7_ncbifamImport  477 -----------------------dpkGRILFNGFSENE-----QAYIALSELKWEKC--------------DDFEKILSP 514
WP_207678643     631 -----------------------sdnVAELIEYFSEHEkdyseYFDKIEHIFDKKNRaa---------tSQDLLDAAISP 678 Desulfonema...
4_ncbifamImport  473 -----------------------aigKKICLHHFEENLyqyilREENPLALQDIYDP----------VQIENWNDEIINN 519
8_ncbifamImport  451 ------------------------------DTTFSDEKvalidEESRDFSDFVPELEek------gfHRSDVRIFEKPEK 494
WP_124327588     607 PAILLLLCHGEADMTNPFRSCLKLKNKDMTIFDLLTVEDv--rLSGSRILLGACESDMVPP-LEFSVDEHLSVSGAFLSH 683 Desulfonema...
9_ncbifamImport  576 PRWLAIWCHGEADPVNFNHSRLLLGNPGVSFFDLQAADLq---LRGASVLLSVCESDLSPPnLSGRLDEHLSLAAPFLHK 652
RLC08521         671 PELMVILSHGASDPTNPFNCRLRLKNGDLRYLDIFQDGPm---LNGTRVILGACETDMASP-PESSLDEHLSLSTAFLQK 746
10_ncbifamImport 521 PEMLVILCHGEADAVNPFNARLKLTGNGISHLEILQSTKm--iLKGSKIILGACETDLVPP-LSDIMDEHLSIATAFLTN 597
5_ncbifamImport  600 PELLTILCHGEADMVNPFRSKLKLVNGGITHLEILKYVNg---VKDTQIILGACETDLVPP-LSDVMDEHTSVATAFLIK 675
KKO18796         624 PEILMILSHGRADMTNPYYARLKLEGGDVSALEIMKAKTgtmsIKGSNVIMGCCETDLLPV-LSTPIDEHVSPATALYTR 702
7_ncbifamImport  515 PELLIIGCHGKADVTSSFNSKLKRKEGDITLLKLLTSKMd---INGSCVIMSVCEADLVPP-LSGPLDEHLSFASAQLIK 590
WP_207678643     679 PRTLTIYCHGQSDVNNPFYSRLLLK----DKLELIKLATlqehYSGTHIFLGACETDLMPP-LSAPLDEQLSMAAMFLQK 753 Desulfonema...
4_ncbifamImport  520 PTLLLLLCHGLCHPINPLETSLIFSNGYLTNQMILESSVn---LAGTRIILGACETDTTPP-ATNHVDEHLSVTSVLLTK 595
8_ncbifamImport  495 LHTLAIVCHGKANPANPFESVLKVG-EGITVKDVLSAG-----LKAKEVYLVACESDLAFP-TAEQVDEHLSLGTVFLSK 567
WP_124327588     684 KAGEIVAGLWTVDSEKVDECYSYLVEEKDf---LRNLQEWQMAETENFRSEnd----sSLFYKIAPFRIIGFP 749 Desulfonema ishimo...
9_ncbifamImport  653 GAGQVLTGLWAVRKDLMFRIVTGSLTTQS----PLWQIVQEQQIGIMKDTGis---eaVRLHRAAPVRVVGWP 718
RLC08521         747 GTQSVMGTLWEVRSGDVEEMVLRIRKSKTaslhEIVWEKQKS--------WiqnpleyQKFYDIIPFRVIGYP 811
10_ncbifamImport 598 GTHEILGTMWQSRPEDIEDIIRLLCDKKTsdtkARGDLWNWQKERI---RDywa-gedAMFYRSVAFRIIGLT 666
5_ncbifamImport  676 KARGILGTMWEVDPIVVEGMIEEFLNKEKipflRNFIHTWQKEKFK---IWakktgntTIFYDTIPFRTFADI 745
KKO18796         703 GANFVVGTMWEINPIDIERHFIELLTKNDnsmlEGVGNWQREGLSD---DKwkkhkesRFFYAIIGFRVLGIF 772
7_ncbifamImport  591 NAREILGGMWIICTEDIMEIINRINNCSHdnldVGAELWHWQREKVEEGIRdyrngvsTSIFRSVTFRIFGLP 663
WP_207678643     754 GVGSVLGTLWEAYPRAVKDIVKNILSADDtqyfEKLFSLKKKISVN----QkkslyyyLCFKLYRSFDQIGKE 822 Desulfonema magnum
4_ncbifamImport  596 GASEILGGLWALMSDQIERLAQTIGAADEqqplYSSLWAYYQELPiey--------irNNLFKTAPFRVAGLP 660
8_ncbifamImport  568 KSRFVFSNLWEAKIEKLKNIVPELVDADDkvsvLMEEMKSKIPEGLPsek-----gvgYRLADALPFRIYDVN 635
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