17543674 1 MAMKIPKS-GYNRFMKEG----AQHFKGTDEAVQRNIEACTELASQIRSAYGPNGMNKMVINHIEKLFVTNDAATILKEL 75 Caenorhabditis elegans 21645567 1 MALSVPKApGVSQMLKDG----ARMYSGLEEAVFRNISACKEFAQTMRSAYGPNGMNKMIINHIEKQFVTSDAGTIMREL 76 fruit fly 15221074 -------------------------------------------------------------------------------- thale cress 6223641 1 MVGMSMQPyGIQSMLKEG----YRHLSGLDEAVIKNIEACKELSTITRTSLGPNGMNKMVINHLDKLFVTNDAATIVNEL 76 thale cress 15236561 -------------------------------------------------------------------------------- thale cress 19074180 1 --------mDIGQTHLGGl--iSNSQQDEKVRYHIVGSRVRMACNLVKSLYGGSHRSKLIVNGYGQILLSSQPGVIYDNV 70 Encephalitozoon cun... 15299423 1 MDSTVPSAlELPQRLALNpresPRSPEEEEPHLLSSLAAVQTLANVIRPCYGPHGRQKFLVTMKGETVCTGCATAILRAL 80 human 7657253 1 MDSTVPSAlELPQRLALNpresPRSPEEEEPHLLSSLAAVQTLASVIRPCYGPHGRQKFLVTMKGETVCTGCATAILRAL 80 human 12644353 1 MALRVPKA-SGPQLFREG----YRIMQGVEDAVIRNCNAIRELSEITRTSLGPNGKNKIVVNHLQQTFLTNDAATIIREL 75 fission yeast 1174622 1 MSLRLPQN-PNAGLFKQG----YNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLREL 75 baker's yeast 9988062 1 MALHVPKApGFAQMLKEG----AKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILREL 76 human
17543674 76 EIQHPAARIIIMATEMQEKQIGDNTNTVVILAAALLEHAANLIHMGMTPQEVAAGYEQAAEKALEILPTLVVK--EATDM 153 Caenorhabditis elegans 21645567 77 DVEHPAAKLIVMASQMQDAEVGDGTNFVVVLAGALLESAEELLRLGITTAEISDGYEKALEKALEILPNLVSH--KIEDY 154 fruit fly 15221074 1 ------------------------------------------------------msdfenivlpsscdsqvtawpvleld 26 thale cress 6223641 77 EIQHPAAKLLVLAAKAQQEEIGDGANLTISFAGELLQNAEELIRMGLHPSEIISGYTKAVSKAVEILEQLVETgsETMDV 156 thale cress 15236561 -------------------------------------------------------------------------------- thale cress 19074180 71 KVNHPLVKLLQEYVKKMD-VIGDGATFFVVLVSELIQEAIDVIGRGMKPACFSSLLREAHKEIDDLGRELLVE--HRIDF 147 Encephalitozoon cun... 15299423 81 ELEHPAAWLLREAAQTQAENSGDGTAFVVLLTEALLEQAEQLLKFGLPRPQLREAYATATAEVLATLPSLAIQ--SLGPL 158 human 7657253 81 ELEHPAAWLLREAGQTQAENSGDGTAFVVLLTEALLEQAEQLLKAGLPRPQLREAYATATAEVLATLPSLAIQ--SLGPL 158 human 12644353 76 EVIHPAAKLVVDATQQQENELGDAANFVVVFTGELLAKAENMIRMGLTPLEIAKGYEMALSHTMEVLEEICAD--KIETV 153 fission yeast 1174622 76 DIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKELDEMVVG--EITDK 153 baker's yeast 9988062 77 EVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVIEGYEIACRKAHEILPNLVCC--SAKNL 154 human
17543674 154 KNIEevrQYIRSAITSKQYDNEDIIADLVAKACVTTCPAnSFn-----FNVDNIRICKIIGSGVHTSTVMNGMVFKRGAE 228 Caenorhabditis elegans 21645567 155 RNVEkvkEVLRTSIMSKQYGQEDFLNDLVSKACVSILPD-EGt-----FNVDNIRICKILGSGLTKSEVVRGMVFKRFVE 228 fruit fly 15221074 27 fnqdtstyvafirvkirlvftdrlrffrrvrfesregamigfeyeklrrictnccrithhvnncpflnapvihddevevl 106 thale cress 6223641 157 RNKDeviSRMRAAVASKQFGQEEIICSLVTDACIQVCPKnPTn-----FNVDNVRVSKLLGGGLHNSCIVRGMVLKSDAV 231 thale cress 15236561 1 ----------------------------------------MT------MNIDDVHVAKILGVDSRKSCVVCGIVFKSDDV 34 thale cress 19074180 148 EDKE-------SISMVLRGVLKDKWLEEIVVEGISLARS---------FSSESIRVCKVACGSVEDSYVVEGMVFNRLPE 211 Encephalitozoon cun... 15299423 159 EDPS---WALHSVMNTHTLPPMNHLTKLVAHACWAIKELdGS------FKPERVGVCTLHGGTLEDSCLLQGLAISGKLC 229 human 7657253 159 EDPS---WALHSVMNTHTLSPMDHLTKLVAHACWAIKELdGS------FKPERVGVCALPGGTLEDSCLLPGLAISGKLC 229 human 12644353 154 ESEKeliKAIRTCISSKQYGNEDFLSDLVAKAILTVLPKdPSk-----FNVDNIRVVKIMGSSLYNSQVVKGMVFPREPE 228 fission yeast 1174622 154 NDKNellKMIKPVISSKKYGSEDILSELVSEAVSHVLPVaQQageipyFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPE 233 baker's yeast 9988062 155 RDIDevsSLLRTSIMSKQYGNEVFLAKLIAQACVSIFPD-SGh-----FNVDNIRVCKILGSGISSSSVLHGMVFKKETE 228 human
17543674 229 GEI---REARDARIAVYTCPFDLTQTETKGTVLIENADELRNFSKGEEAEVEEQVKAIADnarssilakfwlmnfskgee 305 Caenorhabditis elegans 21645567 229 GDvtyaekakivi---fscpvdiiqteTKGTVLIKSADELLSFSSGEESLLESQIKAIAD-------------------- 285 fruit fly 15221074 107 dvpvweegaasntitdqthmtssdssdissaslisqplppaslashephlvagseasrlvnprpipqnhfsssssdfkgk 186 thale cress 6223641 232 GSi---KRMEKAKVAVFAGGVDTTATETKGTVLIHSAEQLENYAKTEEAKVEELIKAVAE-------------------- 288 thale cress 15236561 35 GN-------------IR-HP-------------LKNAK-VHNFGKSKEAMLETLVKDIAF-------------------- 66 thale cress 19074180 212 GEv---KHARQGRTSIYNCPLDISRTELKGTVLMRTASELLSFSKEENKRIKELVESIGA-------------------- 268 Encephalitozoon cun... 15299423 230 GQMaavLSG--ARVALFACPFGPAHPNAPATACLSSPADLAQFSKGSDQLLEKQVGQLAA-------------------- 287 human 7657253 230 GQMatvLSG--ARVALFACPFGPAHPNAPATARLSSPADLAQFSKGSDQLLEKQVGQLAA-------------------- 287 human 12644353 229 Gt---vTRSKEAKVAVFSCPLDISQTETKGTVLLHNAQEMLDFSKGEENLIESHIKEIYD-------------------- 285 fission yeast 1174622 234 GHVkslSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIAD-------------------- 293 baker's yeast 9988062 229 GDV---TSVKDAKIAVYSCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIAD-------------------- 285 human
17543674 306 aeveeqqvkaiadNGVKVVVAAGKFGDMYLHFLNKYKIMAVRLTSKFDLRRLCRTVGAQPQARICAPAVNLLGHCDSVAV 385 Caenorhabditis elegans 21645567 286 -------------AGVKVVVAGGKVGDMALHFLNKYGLMAVRLNSKFDLRRLSRSVNATVLPRITTPSQEELGYCDKVCI 352 fruit fly 15221074 187 gkakmeigecskrkkdkqvvddalrnvrqcrkdqgiRIMILQINLDIELASFVRTAGAVASHKMMKLLTP----FS---- 258 thale cress 6223641 289 -------------SGAKVIVSGGSIGEMALHFCERYKIMVLKISSKFELRRFCRTAGAVAHLKLSRPSPEDLGYVDSISV 355 thale cress 15236561 67 -------------SNVKVIVSRSSICEMTLRFCKIYKIMVLQISSDIDINSLCSIVGAIDSSQHFQPHHL--GYMDSTSL 131 thale cress 19074180 269 ----------------DVIICSGKVDKIYLDFLNKGRKLVFRITSKYDLRRIRELLGGHILSTLEPPAEGSMGVVSEVAT 332 Encephalitozoon cun... 15299423 288 -------------AGINVAVVLGEVDEETLTLADKYGIVVIQARSRMEIIYLSEVLDTPLLPRLLPPQRP--GKCQRVYR 352 human 7657253 288 -------------AGINVAVVLGEVDEETLTLADKYGIVVIQARSWMEIIYLSEVLDTPLLPRLLPPQRP--GKCQRVYR 352 human 12644353 286 -------------AGVRVVVTSGNVNDLVLHYLNRFEILVIRVPSKFELRRLCRVVGATPLARMGVPMPEEMGSVDVVET 352 fission yeast 1174622 294 -------------MGVECIVAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKT 360 baker's yeast 9988062 286 -------------TGANVVVTGGKVADMALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPVLEEMGHCDSVYL 352 human
17543674 386 QEIGDENVVVFDKKSAsnlnflkfseTGKVATIIIRGSSQSRIDDVERAVDDAVNTYKALTKDG--KLLAGAGAVEIELA 463 Caenorhabditis elegans 21645567 353 EELGDTTIVAFRNEg----------kDSRIATVVIRGATDNFMDDIERALDDAINNFKCLTRDG--RYLPGAGATEIELA 420 fruit fly 15221074 259 -------------------------------TVVLRRSKYSILDDLEGYITSGVYTYKVTISTK----LKICFSLYFHLF 303 thale cress 6223641 356 EEIGGVTVTIARNEEG----------GNSISTVVLRGSTDSILDDLERAVDDGVNTYKAMCRDS--RIVPGAAATEIELA 423 thale cress 15236561 132 SEI---------------------------AKRAVKKAERD-AERAERASQKKAEKFKSLRELS--SLKQSKTIPRSKVL 181 thale cress 19074180 333 FREGSTEYTKFISGSK------------KVYTLVLKNSVQAVLDEHERMVQKALVVLSKNVSGGkiGLVDGAGRFERRLS 400 Encephalitozoon cun... 15299423 353 QELGDGLAVVFEWECT----------GTPALTVVLRGATTQGLRSAEQAVYHSIDAYFQPCQDP--RLIPGAGATEMALA 420 human 7657253 353 QELGDGLAVVFEWECT----------GTPALTVVLRGATTQGLRSAEQAVYHGIDAYFQLCQDP--RLIPGAGATEMALA 420 human 12644353 353 IEIGGDRVTVFRQVED----------ITRTATIVLRGATKTYLDDLERAIDDGVNIVKALVKDN--RLIFGAGASDMQLC 420 fission yeast 1174622 361 MEIGGDRVTVFKQEQGe---------ISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSggKLLPGAGATEIELI 431 baker's yeast 9988062 353 SEVGDTQVVVFKHEk----------eDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDK--RLVPGGGATEIELA 420 human
17543674 464 KEIESFGAKAPGLEQYAIKKFAHALETLPKAIAENAGMPTTETLTKLYAEHVa--GKKN------AGIDIWKR---ETMD 532 Caenorhabditis elegans 21645567 421 TQLSAYADTLPGLDQYAVRKFANALEVFPKALAENSGINGTEIVNQLYLAHNn-eAGKT------IGFDIEAEk-aSTID 492 fruit fly 15221074 -------------------------------------------------------------------------------- thale cress 6223641 424 QRLKEYANAEIGLDKYAITKYAESFEFVPKTLADNAGLNAMEIIAALYTGHG---SGNTk-----LGIDLEEG---ACKD 492 thale cress 15236561 182 VQIPVRTTTYQNLKYLSFCVKSQNIYP-PSSMIL---------------------------------------------- 214 thale cress 19074180 401 KAFLERSAGLSGGKSLAYKCIGKALGTFGSSDVEVYDIYNAKIKALKYSMEFvstLFET-------SDYLIGRpeaLNIG 473 Encephalitozoon cun... 15299423 421 KMLSDKGSRLEGPNGPAFLAFARALKYLPKTLAENAGLAVSDVVAEMSGVHQ----GGN------LLMGVGAEg---IIN 487 human 7657253 421 KMLSDKGSRLEGPSGPAFLAFAWALKYLPKTLAENAGLAVSDVMAEMSGVHQ----GGN------LLMGVGTEg---IIN 487 human 12644353 421 IRLISVGEKTPGIYQHAIKQYGEAFEVVPRTISENAGLDPTDVISKLYAAHHk-eNGES------IGVDVECEn-dGTLD 492 fission yeast 1174622 432 SRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNvtePGAVktdhlyKGVDIDGEsdeGVKD 511 baker's yeast 9988062 421 KQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQe--GNKN------VGLDIEAEv-pAVKD 491 human
17543674 533 AVVNNIFDLYAGKRLAIKLATDAASTILKVDQIIMSKQAt-----GGPKPRgPKAqdEDDDG 589 Caenorhabditis elegans 21645567 493 TTKAKLFDLYQSKFWGLKYAVGAAATILKVDQIIMAKRA------GGPKVRqAAG--SDDES 546 fruit fly 15221074 -------------------------------------------------------------- thale cress 6223641 493 VSETKVWDLFATKLFALKYASDAACTVLRVDQVCTN-------------------------- 528 thale cress 15236561 -------------------------------------------------------------- thale cress 19074180 474 PRNNQHWDEEDH-------------------------------------------------- 485 Encephalitozoon cuniculi 15299423 488 VAQEGVWDTLIVKAQGFRAVAEVVLQLVTVDEIVVAKKSpthqqiWNPDSKkTKKrpPPVEK 549 human 7657253 488 VAQEGVWDTLIVKAQGFRAVAEVVLQLVTVDEIVVAKKSpthqeiWNPDSKkTKKhpPPVET 549 human 12644353 493 AKEAGIFDVLLAKKSAIRLATETVLTVLNVDQVVMSKPA------GGPKPP-GPNp-HWDDD 546 fission yeast 1174622 512 IREENIYDMLATKKFAINVATEAATTVLSIDQIIMAKKA------GGPRAPqGPRpgNWDQE 567 baker's yeast 9988062 492 MLEAGILDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPA------GGPKPPsGKKdwDDDQN 547 human
Jiyao W et al.(2023). "The conserved domain database in 2023.",