Conserved Protein Domain Family
VirB4

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COG3451: VirB4 
Type IV secretory pathway, VirB4 component [Intracellular trafficking, secretion, and vesicular transport]
Statistics
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PSSM-Id: 442674
Aligned: 395 rows
Threshold Bit Score: 176.291
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_121616752  101 SSge-lDVLIDIHKVGKTQAVRSLQKQETMLRSNLSWQTkr--------gNIDQINdLQTKIQDTEILMDEIqfSENDMY 171 
NP_817039     220 ATgrelAISIHARPYDMMEARKAIQGTKTLNDVAIQKQQkqnfr-sgvseDAISGE-AKEIQETTNALMDEIknNGQKLF 297 
WP_015760160  279 DLpiplAVSVHIAPIVQSEAIALVKRQIDWMDKEIIDEQttaak-kgfsqSILTPE-IRYAKEEAEELLDFLrnKNEHLF 356 
WP_015760602  295 DLpmplNVTLHIHPMGKAAAVAYVKKRIAWMDKEVIDEQmsavk-kgydfSILPPE-LSHSKEEAEELLDQLqnKNQRLF 372 
WP_041691617  543 ELpinqVITLDMTSWEQSRAIETIESMNTDLKVQKSDYVlkhsqtmyitdEMLPTN-LQDAMENARDLRDDLvsRDQKMW 621 
WP_014081284  256 SLpvhsITSIDVVPVPKDLTTKVLQKKYLGIESDIIKQQrvrnk-nndfsTEISYA-KRTEKKEIEAIMDDVreNDQCLF 333 
WP_041829005  264 QSdlevMISLHAKGSTKSETMTKLRTKKTLMESQKIGEQqkmar-tgiylEKVGHV-LENNIDEAESLLQTMtqTGDKLF 341 
WP_014117317  253 DFsrnlVLSVDIQPVPTDVALKEIQNQALAVETDITRWQnkqnq-nnnfsAIPPMQ-LTEARNNMREFLDDLtaRDQRMT 330 
WP_065534571  253 DFtrtlVLSIDLLPVPTDEAVRDVQSQIMGIESDITRWQqrqna-rnnftAVVPYE-LEQQRAETKEFLDDLstRDQRMV 330 
WP_079536901   41 DLpmplSVNLHIHPIAQSDALALVKRQLDWMDKEIIDEQmsamk-kgydyTILPPE-LRYSKEEAEELLDFLrnKNERLF 118 
WP_121616752  172 NVSSYFMLYANSKKELDRYSEFIEDSMagsfFKLITAWSRVKRGLLSVLPlgrnHMQd---tLRNMDRRALSTFSPFISG 248 
NP_817039     298 NGLFSVFLIAETEKELLEAVESVKNVGatwqVVFDTVDNYKEEALNTILPigkpYLDvemsyMRDLTTTNIATQVPFTNV 377 
WP_015760160  357 EYTGLIYTYADSLEALDRQVAQVKSIAqgnsIAVASLDFRQRPALNSVLPlgrnHLEf----TRYLTTGQIAMQMPFASL 432 
WP_015760602  373 TYTGLVFTYADTAEALDHQTRQIMAAArqrsIEVEPLSYRQRQGMNSILPlglnHVEv----SRYMTTAQIVIQMPFASQ 448 
WP_041691617  622 SLTCTTMTWADSLEDCDENSGAIQDVFrrftCRAVPLVKLQRQGFAAMLPtgrcDIPy----VRNLTTAPLAALVPFTSV 697 
WP_014081284  334 FVGVTIILMAESKKELESVCETVETIGkrnsCTIDTHYLKQREALNTALPigvrQVEt----MRTLLTQSLAVLMPFNVQ 409 
WP_041829005  342 DTVFLIGVLADTEDQLKQSLDIIKQVAgsndMIIDNLTYMQEAAFNSLLPfgknYLEg---vSRSLLTSNIAVNAPWTSV 418 
WP_014117317  331 LCVMTLVHIADSKKQLDADTDTIRSIAggknCELSVLTYQQEDGLNTALPyglrKIDt----LRTLTTESAAALVPFSSQ 406 
WP_065534571  331 YANVTLLHMADTLEQLNADTETL---LskslCDFSILRYQQEDGFNTALPyglrSIDv----TRTLTTEAAASLMPFRVQ 403 
WP_079536901  119 TYTGLIYTYADTVDALERQIDQIVSIGqgnsLGIEPLYYRQRQALNSVLPlgmnHIDv----TRYLTTGQIAMQMPFASL 194 
WP_121616752  249 SArYTGGVPFgINKITGQKEFINSFgnDdwrPDNYNMGIFGISGSGKSLAMKLKIARE-MA----GANIyaGIIDPEGEF 323 
NP_817039     378 ELqSPTGQFYgRNQLTKNMITIDRKk-D---LITPSGLIFGTSGSGKGMATKWEILSTrLKf--pKDRF--LIVDPESEY 449 
WP_015760160  433 ELnQEGGgYYgQSKQSGNLVICNRKl-----LASPMGFVCGKPGSGKSFSVKREITNTvLAh--pEDQI--IVFDPAGEY 503 
WP_015760602  449 ELnQEGGgYYgQSKQSGNLVICNRKk-----LASPMGFVCGKPGSGKSFSVKREIMNTiLAy--pDDEV--IVFDPAGEY 519 
WP_041691617  698 ELmERGGMWMgQNQTSKNFIFYNRRd-----AVAPNGFILGKPGRGKSVTAKNTILWTlLTd--pTAEV--IVLDPEREY 768 
WP_014081284  410 ELnDSTGNYYgINQISKNVNIGNRKk-----LINGNGFVFGVPGSGKSFFCKMEMGSVfLSg---DDEI--IVIDPMNEY 479 
WP_041829005  419 DIqDKGGKFYgINQISSNIISIDRGk-----LNTPSGLILGTSGAGKGMATKHEIISTkLKeadcDTEI--IIVDPENEY 491 
WP_014117317  407 EIrHRNGIYYgVNATSRNLIVCNRRq-----LLNGNGFILGVSGSGKSFAAKEEITSIaLSt---DDDI--LIVDPEREY 476 
WP_065534571  404 EIqDMGGIYCgVNAVSKNLLICNRKn-----LLNPHGFILGVSGSGKSFTMKEFITFIaLSt---NDDI--IIIDAEREY 473 
WP_079536901  195 ELnQEGGgYYgQSKQSGNLVICNRKk-----LASPMGFVCGKPGSGKSFSVKREITNTvLAy--pEDEI--IIFDPAGEY 265 
WP_121616752  324 VKLTNRLGGVNLDIheESGLVINPCAlnfsdIplddkddeelealededdkevvekngkkylrfvpvreKINEILDFFDI 403 
NP_817039     450 LPIGKELDAEILDIstGTKNHLNILG-----Mvdkqlldee-------------------dqeldlvkeKSNLLSTMFES 505 
WP_015760160  504 PTLIEALGGSNIAFspDSPTRLSPFD-----Rsdvanma-----------------------ttsqmafKIDAFLALSSA 555 
WP_015760602  520 APVVEPAGGTCIRFspDTDTFMNPFD-----Lsdvadka-----------------------nqaqlafKIDAILALSSA 571 
WP_041691617  769 INVAREMDGEVVQIsgDSHTYINPFD-----Lelvege--------------------------qplamKVDAIMSMVEM 817 
WP_014081284  480 FDIAQTYGGTVVNMsiYTDNYVNPLE-----Mdvwsldpn---------------------dskgmireKGEFMLGLCEQ 533 
WP_041829005  492 SIIGQAFGGESIDIapDSTTFLNVLD-----Lsdenmd-------------------------edpvkvKSEFLLSWIGK 541 
WP_014117317  477 APLVRALGGEVVQIsaGSPNHINAMD-----Masgygevdg--------------------ktenplilKSQFIMSLCEQ 531 
WP_065534571  474 GDLVRALRGIVLEIspNSRHHINPLE-----Iargygmg------------------------enpvalKSELLMSICEQ 524 
WP_079536901  266 GNLIEALGGVNVRLapDADTALNPFD-----Lsdvegra-----------------------daaqlafKIDAFLALSSA 317 
WP_121616752  404 IIrgkGsEDGGLDvFERNYLEESIQAVFaeLgittHPeslfesevkevdgqiiqssvrkpepELLQIYNKLVENhgtdik 483 
NP_817039     506 LL-------KSYTdVDAGLVDRVTLLTYerFenke------------------------tepTLVDWFRILKEQtd--eg 552 
WP_015760160  556 MM---AeGDEGLPeADKSIITRCVEAAYakrgg-------------------------dgtpTLSDFYEILKAQpe--re 605 
WP_015760602  572 TM---AeGREGLPeADKSIISRCVELAYmrceg------------------------kgrlpVLGDFYELLLEQee--pe 622 
WP_041691617  818 MA-------KNLSpMQKTLVDRCVSRIYdrYf--aTHdqr-------------------dipTLIDFYNMLNQQpe--pe 867 
WP_014081284  534 CI---G---DSLNsRQKSIIDRCVRKMYid---iaRGrek-------------------yipVMSDFYDILMEQpe--de 583 
WP_041829005  542 LL---D---RKMDgREKSLIDRVTRLTYkhFdt----------------------------pSLVEWVFVLAQQpe--qe 585 
WP_014117317  532 LM-----KPEVVGaKEKSIIGRCVGNVYrdYikny-----------------------enppTLKEFREELLRQpe--pq 581 
WP_065534571  525 QM-----GEGQLGaFHKSIIDRCTASVYhdFi--kSGgka-------------------rqpILSDWRNEIKRQpe--re 576 
WP_079536901  318 MM---AeSSEGLPeADKSIITRCVEAAYskcad------------------------gqgvpTLSDFHEILSGQpe--te 368 
WP_121616752  484 AERIIAATKPFLrtGSkpIFDGQTfLgrgitqSMenARLINFNISQlEEGfLRPIAFHVILNYLwEYFAKNinNADK-KK 562 
NP_817039     553 AKELANKVETYCv-GSqdIFAHQTnI------DLt-APFIVFNTKKlDDR-LKKFAMKVILDQLwKQVVSG---QGKvTS 620 
WP_015760160  606 SRDIALRYERYVs-GPlsFFNCQSnV------TFd-ERIVNVDLHElSSS-MRVFGMLTALEAVrNRMYANy-ERGV-TT 674 
WP_015760602  623 ARDIALRYERYVk-GAlsFFNHQSnV------GFt-NRITNVDFKDlSQN-MRVFGMLTALEAVrNRMYANf-ERGV-TT 691 
WP_041691617  868 GRMLAVTIERYVt-GQasLFNHPTnV------NTh-KRFVVYDIRDcADN-MKGLALLILLDQTwNRIVRNr-ERHV-RT 936 
WP_014081284  584 AKDIALSLELFVn-GSlnIFNHQTnV------DVd-NRFTVYGIRDlGTE-LSPITMLVMMESIqNRIVENg-QKGK-AT 652 
WP_041829005  586 AKDLALDMELYVe-GSldIFSHRTnI------KTd-SHFLIYNVKKlGDE-LKQIALMVIFDQIwNRVVKNq-KLGK-KT 654 
WP_014117317  582 AQSIALALELFTd-GSlnVFAHQTnV------NMn-NRIMLFDIFDlGSQ-LKTVGMLVMLDAIlNRVIENh-KRGR-RT 650 
WP_065534571  577 AQELALASELFVe-GSlnMFAHETnV------DId-SRIIVFDLYEmGDQ-LKPTALNVTMETIqNRVATNr-LAGK-YT 645 
WP_079536901  369 ARDIALRYERYVt-GAlsFFNRQSnV------GFd-NRITNIDLHDlSTN-MRVFGMLTALEAVrNRMYANf-ERGI-TT 437 
WP_121616752  563 FIYADELWQFIDNDQTVTFFEKVARRIRKRNGGLMYASQDFVRLLENpKSRGILTNTFTILFLRQNKIDLKkIRENFNLT 642 
NP_817039     621 RLYFDELQVNFTTEEEAEWFLNLWARIRKYGAVTTGITQNPTTLLDSkAGQKMIANSEFLILLRQKPIDSQrLVEILSLT 700 
WP_015760160  675 WLYIDEVQSLFGHPAIIEYFTKFWAEGRKFNLIATGITQNSTYMLAHeDARNMVLNSDFVLLHKQSALDRKsWVDLLSLS 754 
WP_015760602  692 WLYIDEVQSLFGHPAIISYFSKFWAEGRKFNLICTGITQNSTYMLEHeDARNMVLNSDFVLLHKQSHLDRKsWVDLLALS 771 
WP_041691617  937 WVFIDEMQLLFENDYAISYFDQLWTRSRKYGAIPTGITQNIERIINNeKSRLMLANSDFLVLLGQSASDAAaLGEVIKLS 1016
WP_014081284  653 WLYIDEFHVLLNSEYSAKYLQQLWKKVRKQGGLCTGITQNVVDLLQNyTATTMLANSEFVALLKQANTDSSkMAEVIGVS 732 
WP_041829005  655 WIYFDEMQLLLLDKYASDFFFKLWSRVRKYGAIPTGITQNVETLLLDaNGRRIIANSEFMILLKQAKSDREeLVHILGLS 734 
WP_014117317  651 WIYIDEIYLFFTNEYSTNFLEESWKRFRKKNAAATGITQNVTDCLRSpTAKNMLANSEFLLMLSQAPTDQQeLVNLLRIS 730 
WP_065534571  646 WVFVDEVYLFFKYYYSAQFLYKAWKRFRKYGAALTAATQNVEECLRSeTARLMFANSEFLVLLNQAATDRAeLAKLLNIS 725 
WP_079536901  438 WLYIDEVQSLFGHPTIIDYFAKFWAEGRKFNLICTGISQNTSHMLTHeRARTMVLNSDFMLLHKQASQDLAaWADMLSLS 517 
WP_121616752  643 DGEIDILfGN-P-DKGEgILRqGESSVWL-QtdpsD--EEL--IFiESN 684 
NP_817039     701 PALKKYI-NDrA-PQGTgLISaGGVVVPFeNp--iPkeTHLfeIM-NTD 744 
WP_015760160  755 ATEAGYI-DD-TvKAGEgLLVaGGVRVPIrDd--fPk-GALydLF-NTK 797 
WP_015760602  772 AQEegyiddsikagegllvaggvrvplkddfpkgalydlfntkpeeiaq 820 
WP_041691617 1017 ERQVAMM-RN-A-GPGEgLLVaGGKIIPFeNr--iPtdSAIyrMV-TTK 1059
WP_014081284  733 EAQLRFV-TN-T-ASGMgLIKcGSVVIPFdNq--iSkdTDLyrLY-NTN 775 
WP_041829005  735 KELEKYL-VN-P-EKGAgLIKaGSTVVPFkNk--iPqhTMLfdIM-STD 777 
WP_014117317  731 EQQLGYI-TN-A-EVGHgLIKvGGALVPFiNh--fPanTELykLM-TTK 773 
WP_065534571  726 ENQMGYV-TN-A-EAGHgLLRvGGAIVPFaNe--fPrtGALyqLW-NTT 768 
WP_079536901  518 AAEKEYI-DE-SiKAGEgLLVaGGARVPIrDd--fPk-GALydLW-NTK 560 
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