Conserved Protein Domain Family
LpxB

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COG0763: LpxB 
Lipid A disaccharide synthetase [Cell wall/membrane/envelope biogenesis]
Lipid A disaccharide synthetase is part of the Pathway/BioSystem: Lipid A biosynthesis
Statistics
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PSSM-Id: 440526
Aligned: 640 rows
Threshold Bit Score: 238.042
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_084330615  45 F-----TAAIVAGEPSGDLLAARMLRGLR-ARDPQVRARGIGGPAMAREG-F-EAWHPMDALSVFGYVDALRRAPRLIRT 116
NP_219921    221 rkpfsnSCFISAGEHSGDTLGGNLLKEMH-AKYPDIHCFGVGGPQMRAQN-F-HALFAMEKFQVSGFWEVLLALPKLWYR 297
NP_225158    222 T-----HCFLSAGEASGDILGGKLIQSIK-SLYPNIRFWGVGGPAMRQEG-L-QPILNMEEFQVSGFAEVLGSLFRLYRN 293
WP_013181510   1 Ms---hSLFLIAGEKSGDMLGCNLMKALK-EQMPGTAFAGVGGQEMRQEG-L-DCVLRTEDFELHGFSDIIRSVPKLIKQ 74 
NP_220704      1 Mk----KIYFIAGEMSGDFIGGHVIQNLK-S-NEGLEFTGIGGKYMEEAGnF-KSLFTITAINLIGFIEIIPHLLKIKKL 73 
WP_013951178  14 Y-----KIAIIAGEPSGDLIAAKLLNQLQqKI--SVDARGVGGENMIKRG-F-KTIFPMKNLSIMGYFEGIAKLPIILIR 84 
WP_013924331   1 MnakqkSIFLFAGEQSGDLHGQNLLQHLQ-QKLPDYTFSGVGGPLMRPFF-T-SSVLRMEDFEVMGFSDVLRSLPKLTRQ 77 
WP_052646478   3 P-----KIFIIAGEPSGDLIGANLIKSLK-LLLPNCSIYGVGGSKMISQG-L-NSIFDIEEISIMGYIEVLPKIFKIKKL 74 
WP_059060149   1 Mr---kDCFIFAGESSGDLHGSRLLKALK-NGPTFNSFRGIGGPLMRQEG-L-ECLFKMESFQVMGFSDVIKALPSLWKH 74 
WP_106874318   1 Ms----KLYFIAGEASGDFLGSKIISSLL-EKNKDLKIYGIGGDKMLSAG-LkESLFSMNKISLMGIFEVLWHVLEIRGL 74 
WP_084330615 117 WRDTRRRTLDWRPDVFVGVDAPDFNLRLEEKLRAA---G--IPTVHFVGPSIWAWRFERIHQIRRAVSHMLVLFPFEVEL 191
NP_219921    298 YQLLYRNILKTNPRTVICIDFPDFHFLLIKKLRSR---GykGKIVHYVCPSIWAWRPSRKTVLEKYLDLLLLILPFEQNL 374
NP_225158    294 YRKILKTILKHKPATLIFIDFPDFHLLLIKKLRKH---GyrGKIIHYVCPSIWAWRPKRKRILEQHLDMLLLILPFEEGL 370
WP_013181510  75 FKTIRNWILSKNPDAVIFIDYPGFNLRMAKSLRKK---GyrGKLVQYVCPTIWAWGRKRKQKMEEALDLVLSIYPFEPAY 151
NP_220704     74 IDKTVEHIINSKADLLITIDSPGFTYRVAKRVRKLl-pN--LKMIHIVAPSVWAYKADRAVNYAKIYDCLFALLPFEPPY 150
WP_013951178  85 LFQTARWIKSYNPDILITVDSPGFNLRLVKKLRKQq-vA--FPIVQYVAPTVWAYKTERAKKFADLYDHIFAILPFEKKY 161
WP_013924331  78 FYQVRNAILDTLPEAVILIDYPGFNLRLAKALRKK---GykGKIVQYICPSVWAWGKGRIEHMANTLDLLLSIVPFEKQL 154
WP_052646478  75 LTKTYQEIIKINPDVIITIDSPGFNLRLIKRLRKYfgnK--IKIVNYVAPSVWAYKPKRIYRVKALYDHQLLILPIEKPY 152
WP_059060149  75 FYAIRNHILDTKPTCTILIDYPGFNLRLAKALRKG---GyqGKIVQYICPTVWAHGKKRIEAMVSSLDLLLTIYPFESDL 151
WP_106874318  75 IKKTVEHILKVNPQVLITIDSPGFNFRVVEEIKKLa-pH--IVRIHIVAPSVWAYKPERAIKTAWIYNHLLTLLPFEPPL 151
WP_084330615 192 YRGQGVPVTYVGHPLAELIPVRP-DRAAARARLGLEpGRRVLALMPGSRESEIRLLAPRFLQAAQM--LvrqdPGLRIVV 268
NP_219921    375 FKDSALRTVYLGHPLSETIKSFS-PNLNWKDQLHLPtDKPFIAAFPGSRRSDILRNLTIQVQAFQAssLa---sTHHLLV 450
NP_225158    371 FKNTSLETVYLGHPLVEEISDYK-EQASWKEKF-LNsDRPIVAAFPGSRRGDISRNLRIQVQAFLNssLs---qTHQFVV 445
WP_013181510 152 FENSPLKVEYVGNPVKKIVQNHK-HDENWHALFGIKkMDHLIAIFPGSRKGEIQRNLPYQLKTCEL--MkkknPNLVFAI 228
NP_220704    151 FTKVGLDCRYIGHPIMEQEFYR--DKIALRKELKIDeNERILCVTLGTRKGEILRHLPIFIDAIQE--IskdyKNLTIIF 226
WP_013951178 162 FDEAHLPCTYVGHPVLEDEEITS-SKEEIKEKFGFNkQDQLITVTPGSREQEIKYHLKVLLEAVSR--LiskyHGIYFII 238
WP_013924331 155 FSHTPLRVEYIGNPLLTSIQSYS-YHQDWMELLGIKpANQLIALFPGSRKGEIQRNLPIQLKAAQL--Mkr--eDRTFAI 229
WP_052646478 153 FDTIGFPSTFVGHPILEEPLVQSlSKEETYTKYNVPlKNKLLTIMPGSRKGELKKHIPIFIEALKN--IknkqPNITLFI 230
WP_059060149 152 FAKTSLKATYIGNPLVETVQKHA-YQPHWKQVLNIPeEQQLIAIFPGSRLGEIQRHTQHQLQVAYK--LkekyPSLGFAI 228
WP_106874318 152 FEKYGLKSDFIGHPIFEQDFDKK-ENSELADFVSLSk-EPIIAITPGSRASEIKMHLKTFTSAV----LqsdfPEAKCII 225
WP_084330615 269 PMVNQHRRAQFEAILAQHpvPG----CRVLSalpgtgqgpaqgrgpaaapdaparadgqdtadwPIAWHAMEAADAVLVA 344
NP_219921    451 SSANPEYDHLILEVLQQNrcLH----SHIVPs--------------------------------QFRYELMRECDFALAK 494
NP_225158    446 SSSSAKYDEIIEDTLKAEgcQH----SQIIPm--------------------------------NFRYELMRSCDCALAK 489
WP_013181510 229 SCAHEKIMPVMHPMLRNVs-LKlhqdLFLLPk--------------------------------TYSYELMRDCRSALAK 275
NP_220704    227 PLAHPDHEAIIKPFLDNIq-FN----YLFLS---------------------------------NERLKAYAVSDLALAK 268
WP_013951178 239 PTFPRLL-HIYQEILSNYq-FR----EYILLkt-----------------------------daEEKRALLYASNAAFIK 283
WP_013924331 230 SCAHPEIIPVMQSILEETd-LKlhqdVFLVPk--------------------------------AYTYELMKDSHAAIAK 276
WP_052646478 231 PTLPHLE-EILKKEFGQFs-------PLISSd-------------------------------sKTKDELLFASDVALVK 271
WP_059060149 229 SCAHDDLYPILQEQIKKTp-LEqgkdIHLVPr--------------------------------AYSYELMKECSMALAK 275
WP_106874318 226 VCVSEEHRSLVDKMLKGTr-LQy-----ITT---------------------------------LDKIAAFHIADLVIAK 266
WP_084330615 345 SGTATLEAALFKRPLVISYVITPWmrrimTWKSGQDAPS--LPWIGLPNILEREFVVPELLQ--EAATPQALAEHTWAAL 420
NP_219921    495 CGTIVLETALNLTPTIVTCQLRPL-----DTFLAKYIFNiiLPAYSLPNIILGRTIFPEFIGgkKDFQYEDVAAALN-IL 568
NP_225158    490 CGTIVLETALNQTPTIVMCRLRPF-----DTFLAKYIFKilLPAYSLPNIIMNSVIFPEFIGgkKDFHPEEIATALD-LL 563
WP_013181510 276 SGTVTLELALHQTPTVVLYKLTWL-----NRFIAKYLLRlnLPHYCIVNILSNQTVYPEVIE--KGLSAQNLYKKLMPLN 348
NP_220704    269 SGTNTLEISASGTPMVVAYKVNII-----SFIIIMLLIK--IKYVSLINIIAGSEIIPEFIQ--FNCKANLISNKLKELL 339
WP_013951178 284 SGTVAIECALLKVPMLIFYKVSKI-----TAWLIRKKIK--IRYISILNLMADKMIIPELIQ--ENFTADNLFKEMDKLL 354
WP_013924331 277 SGTVTLELALHQRPSTVIYQLTAL-----NRFIAKYILRlnLPYYSIANILAQKQLFPELIA--TGLTPKNVHAKMEDLA 349
WP_052646478 272 SGTSSLELMRYNLPMIVAYKVSGL-----TAFILKFFIT--TKYFALPNIILQEEVVPELIQ--DKCTAENISKALYVLL 342
WP_059060149 276 SGTVTLELALHRKPSVVLYTLTAL-----NYYIAKYWMRlnLPHYCIVNILGKKEIFPELIG--RELDCDRLYENLDALL 348
WP_106874318 267 SGTNTLEIAACATPMIVGYKFNIF-----TWQYLKRLLK--IKYASLINIFADHPIIPELIQ--NNCNPEKISEKLNSFI 337
WP_084330615 421 TDA--ALAERISRRFTALHETLS-RD----TPGLAA-QAILD-VS-HGHA 460
NP_219921    569 KTS--QAQEKQKDSCRDVYQAIN-ESa---SSMKEClSLIFE-TA-S--- 607
NP_225158    564 NQH--GSKEKQKEDCRKLCKVMT-Tgq--iASEEFL-KRIFD-TLpAv-- 604
WP_013181510 349 GHT--EERRQCIEKCQELDQLLQ-NKd---ASRQAA-LAVRE-LI-G--- 386
NP_220704    340 SNS--QKRYNQVVKSKKILQKLGfESnr-sPSYIAA-KIIKQeFL----- 380
WP_013951178 355 EEG-----EKQVNQLDEIIQKLK-VGnatkPSQIAA-EVILK-IL-PERD 395
WP_013924331 350 -DPxsNNRQTCIQQCQDLVPFLS-QKn--nPCEQAT-QALLE-ML-GR-- 390
WP_052646478 343 NNK--EKQDYQKEKFNLALNMFNvKSge-kPGMLAA-KKIAE-LL----- 382
WP_059060149 349 QKN--SLYTSIEKECASIQQQLG-THs---ASSQAS-QAIQE-LF-Qc-- 387
WP_106874318 338 KDS--TLRKNQITRSSQILEQMGlRQdi-sPTQKAA-ELISR-YI-Ky-- 379
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