CCDS Home FTP Process Releases & Statistics
Collaborators EBI HGNC MGI NCBI
Contact Us email CCDS
Genome Displays Related Resources Gene HomoloGene MANE RefSeq
|
|
Report for CCDS46525.1 (current version)
CCDS |
Status |
Species |
Chrom. |
Gene |
CCDS Release |
NCBI Annotation Release |
Ensembl Annotation Release |
Links |
46525.1 |
Public |
Homo sapiens |
2 |
SERPINE2 |
24 |
110 |
108 |
|
Public Note for CCDS 46525.1 |
This CCDS representation is supported by the mRNA AK295564.1. It contains an alternative 5' exon compared to other variants at this locus, as represented by CCDS2460.1 and CCDS46526.1. It should be noted that the annotated start codon in this CCDS has a weak Kozak signal and is only conserved among primate species. It is possible that leaky scanning by ribosomes could occur to allow a downstream start codon to be used at least some of the time. The downstream start codon has a stronger Kozak signal and is much better conserved, and it would result in a protein that is 12 aa shorter at the N-terminus. There is no experimental evidence indicating which start codon is preferentially used by this variant in vivo. Signal peptides can be predicted for both the longer and shorter N-termini (cleavage following aa 31 or aa 19, respectively), but it should be noted that the probability of signal peptide occurrence is reduced for the longer N-terminus, as predicted by SignalP 3.0 and Phobius. It is unknown if a signal peptide is cleaved from the longer protein in vivo. |
Public since: CCDS release 6, NCBI annotation release 37.1, Ensembl annotation release 55
Review status: Reviewed (by RefSeq, Havana and CCDS collaboration) Sequence IDs included in CCDS 46525.1
Original |
Current |
Source |
Nucleotide ID |
Protein ID |
MANE |
Status in CCDS |
Seq. Status |
Links |
---|
|
|
EBI |
ENST00000447280.6 |
ENSP00000415786.2 |
|
Accepted |
alive |
|
|
|
NCBI |
NM_001136530.1 |
NP_001130002.1 |
|
Accepted |
alive |
|
RefSeq |
Length |
Related UniProtKB/SwissProt |
Length |
Identity |
Gaps |
Mismatches |
NP_001130002.1 |
409 |
P07093-3 |
409 |
100% |
0 |
0 |
Chromosomal Locations for CCDS 46525.1
Assembly GRCh38.p14 (GCF_000001405.40)
CCDS Sequence Data |
---|
Blue highlighting indicates alternating exons. | Red highlighting indicates amino acids encoded across a splice junction. | | Mouse over the nucleotide or protein sequence below and click on the highlighted codon or residue to select the pair. |
Nucleotide Sequence (1230 nt): ATGAGTGACTGCAGGTCGTCCTTGGTGGAAGGAACCATGAACTGGCATCTCCCCCTCTTCCTCTTGGCCT CTGTGACGCTGCCTTCCATCTGCTCCCACTTCAATCCTCTGTCTCTCGAGGAACTAGGCTCCAACACGGG GATCCAGGTTTTCAATCAGATTGTGAAGTCGAGGCCTCATGACAACATCGTGATCTCTCCCCATGGGATT GCGTCGGTCCTGGGGATGCTTCAGCTGGGGGCGGACGGCAGGACCAAGAAGCAGCTCGCCATGGTGATGA GATACGGCGTAAATGGAGTTGGTAAAATATTAAAGAAGATCAACAAGGCCATCGTCTCCAAGAAGAATAA AGACATTGTGACAGTGGCTAACGCCGTGTTTGTTAAGAATGCCTCTGAAATTGAAGTGCCTTTTGTTACA AGGAACAAAGATGTGTTCCAGTGTGAGGTCCGGAATGTGAACTTTGAGGATCCAGCCTCTGCCTGTGATT CCATCAATGCATGGGTTAAAAATGAAACCAGGGATATGATTGACAATCTGCTGTCCCCAGATCTTATTGA TGGTGTGCTCACCAGACTGGTCCTCGTCAACGCAGTGTATTTCAAGGGTCTGTGGAAATCACGGTTCCAA CCCGAGAACACAAAGAAACGCACTTTCGTGGCAGCCGACGGGAAATCCTATCAAGTGCCAATGCTGGCCC AGCTCTCCGTGTTCCGGTGTGGGTCGACAAGTGCCCCCAATGATTTATGGTACAACTTCATTGAACTGCC CTACCACGGGGAAAGCATCAGCATGCTGATTGCACTGCCGACTGAGAGCTCCACTCCGCTGTCTGCCATC ATCCCACACATCAGCACCAAGACCATAGACAGCTGGATGAGCATCATGGTGCCCAAGAGGGTGCAGGTGA TCCTGCCCAAGTTCACAGCTGTAGCACAAACAGATTTGAAGGAGCCGCTGAAAGTTCTTGGCATTACTGA CATGTTTGATTCATCAAAGGCAAATTTTGCAAAAATAACAAGGTCAGAAAACCTCCATGTTTCTCATATC TTGCAAAAAGCAAAAATTGAAGTCAGTGAAGATGGAACCAAAGCTTCAGCAGCAACAACTGCAATTCTCA TTGCAAGATCATCGCCTCCCTGGTTTATAGTAGACAGACCTTTTCTGTTTTTCATCCGACATAATCCTAC AGGTGCTGTGTTATTCATGGGGCAGATAAACAAACCCTGA
Translation (409 aa): MSDCRSSLVEGTMNWHLPLFLLASVTLPSICSHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGI ASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVT RNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQ PENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAI IPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITRSENLHVSHI LQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINKP
|