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Report for CCDS3440.2 (current version)

CCDS Status Species Chrom. Gene CCDS Release NCBI Annotation Release Ensembl Annotation Release Links
3440.2 Public Homo sapiens 4 STIM2 24 110 108 CCDS HistoryNCBI Gene:57620Re-query CCDS DB by CCDS ID:3440.2Re-query CCDS DB by GeneID:57620See the combined annotation on chromosome 4 in Sequence Viewer

Public Note for CCDS 3440.1
The coding region has been updated to shorten the N-terminus to one that is more supported by data in PMID:1146333. This publication shows that a non-AUG translation initiation codon is used exclusively. The UUG start codon annotated in the update is conserved as an AUG in rat and mouse. An upstream in-frame putative AUG start codon exists in the transcript, which would result in a protein that is 87 aa longer at the N-terminus, but the studies in PMID:1146333 do not support usage of this. In addition, a signal peptide is predicted only if the downstream start codon is used, and the same publication performed N-terminal sequencing of the mature protein to confirm the signal peptide cleavage.

Public since: CCDS release 1, NCBI annotation release 35.1, Ensembl annotation release 23

Review status: Reviewed (by RefSeq, Havana and CCDS collaboration)


Attributes
CDS uses downstream AUG
Non-AUG initiation codon

Sequence IDs included in CCDS 3440.2

Original Current Source Nucleotide ID Protein ID MANE Status in CCDS Seq. Status Links
Original member Current member EBI ENST00000467087.7 ENSP00000419073.2 MANE Select Accepted alive Link to Ensembl Transcript Viewer:ENST00000467087.7Link to Ensembl Protein Viewer:ENSP00000419073.2Re-query CCDS DB by Nucleotide ID:ENST00000467087Re-query CCDS DB by Protein ID:ENSP00000419073
Original member Current member NCBI NM_020860.4 NP_065911.3 MANE Select Accepted alive Link to Nucleotide Sequence:NM_020860.4Link to Protein Sequence:NP_065911.3Re-query CCDS DB by Nucleotide ID:NM_020860Re-query CCDS DB by Protein ID:NP_065911Link to BLAST:NP_065911.3

RefSeq Length Related UniProtKB/SwissProt Length Identity Gaps Mismatches
NP_065911.3 746 Q9P246-1 746 100% 0 0

Chromosomal Locations for CCDS 3440.2

Assembly GRCh38.p14 (GCF_000001405.40)

On '+' strand of Chromosome 4 (NC_000004.12)
Genome Browser links: Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 4Link to Ensembl Genome Browser on chromosome 4See the combined annotation on chromosome 4 in Sequence Viewer

Chromosome Start Stop Links
4 26861219 26861369 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 4Link to Ensembl Genome Browser on chromosome 4
4 26919504 26919634 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 4Link to Ensembl Genome Browser on chromosome 4
4 26957612 26957726 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 4Link to Ensembl Genome Browser on chromosome 4
4 26995379 26995490 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 4Link to Ensembl Genome Browser on chromosome 4
4 26999232 26999347 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 4Link to Ensembl Genome Browser on chromosome 4
4 27002217 27002394 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 4Link to Ensembl Genome Browser on chromosome 4
4 27002927 27003104 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 4Link to Ensembl Genome Browser on chromosome 4
4 27007533 27007700 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 4Link to Ensembl Genome Browser on chromosome 4
4 27008428 27008528 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 4Link to Ensembl Genome Browser on chromosome 4
4 27008764 27009002 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 4Link to Ensembl Genome Browser on chromosome 4
4 27017711 27017984 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 4Link to Ensembl Genome Browser on chromosome 4
4 27022519 27022996 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 4Link to Ensembl Genome Browser on chromosome 4

CCDS Sequence Data
Blue highlighting indicates alternating exons.
Red highlighting indicates amino acids encoded across a splice junction.
 
Mouse over the nucleotide or protein sequence below and click on the highlighted codon or residue to select the pair. This works on the replacement symbol in the Translation Exceptions section also.

Translation Exceptions:
replace the symbol L (codon TTG) with M at amino acid position 1

Nucleotide Sequence (2241 nt):
TTGCTGGTGCTCGGGCTGCTGGTAGCCGGAGCGGCGGACGGATGCGAGCTTGTGCCCCGGCACCTCCGCG
GGCGGCGGGCGACTGGCTCTGCCGCAACTGCCGCCTCCTCTCCCGCCGCGGCGGCCGGCGATAGCCCGGC
GCTCATGACAGATCCCTGCATGTCACTGAGTCCACCATGCTTTACAGAAGAAGACAGATTTAGTCTGGAA
GCTCTTCAAACAATACATAAACAAATGGATGATGACAAAGATGGTGGAATTGAAGTAGAGGAAAGTGATG
AATTCATCAGAGAAGATATGAAATATAAAGATGCTACTAATAAACACAGCCATCTGCACAGAGAAGATAA
ACATATAACGATTGAGGATTTATGGAAACGATGGAAAACATCAGAAGTTCATAATTGGACCCTTGAAGAC
ACTCTTCAGTGGTTGATAGAGTTTGTTGAACTACCCCAATATGAGAAGAATTTTAGAGACAACAATGTCA
AAGGAACGACACTTCCCAGGATAGCAGTGCACGAACCTTCATTTATGATCTCCCAGTTGAAAATCAGTGA
CCGGAGTCACAGACAAAAACTTCAGCTCAAGGCATTGGATGTGGTTTTGTTTGGACCTCTAACACGCCCA
CCTCATAACTGGATGAAAGATTTTATCCTCACAGTTTCTATAGTAATTGGTGTTGGAGGCTGCTGGTTTG
CTTATACGCAGAATAAGACATCAAAAGAACATGTTGCAAAAATGATGAAAGATTTAGAGAGCTTACAAAC
TGCAGAGCAAAGTCTAATGGACTTACAGGAGAGGCTTGAAAAGGCACAGGAAGAAAACAGAAATGTTGCT
GTAGAAAAGCAAAATTTAGAGCGCAAAATGATGGATGAAATCAATTATGCAAAGGAGGAGGCTTGTCGGC
TGAGAGAGCTAAGGGAGGGAGCTGAATGTGAATTGAGTAGACGTCAGTATGCAGAACAGGAATTGGAACA
GGTTCGCATGGCTCTGAAAAAGGCCGAAAAAGAATTTGAACTGAGAAGCAGTTGGTCTGTTCCAGATGCA
CTTCAGAAATGGCTTCAGTTAACACATGAAGTAGAAGTGCAATACTACAATATTAAAAGACAAAACGCTG
AAATGCAGCTAGCTATTGCTAAAGATGAGGCAGAAAAAATTAAAAAGAAGAGAAGCACAGTCTTTGGGAC
TCTGCACGTTGCACACAGCTCCTCCCTAGATGAGGTAGACCACAAAATTCTGGAAGCAAAGAAAGCTCTC
TCTGAGTTGACAACTTGTTTACGAGAACGACTTTTTCGCTGGCAACAAATTGAGAAGATCTGTGGCTTTC
AGATAGCCCATAACTCAGGACTCCCCAGCCTGACCTCTTCCCTTTATTCTGATCACAGCTGGGTGGTGAT
GCCCAGAGTCTCCATTCCACCCTATCCAATTGCTGGAGGAGTTGATGACTTAGATGAAGACACACCCCCA
ATAGTGTCACAATTTCCCGGGACCATGGCTAAACCTCCTGGATCATTAGCCAGAAGCAGCAGCCTGTGCC
GTTCACGCCGCAGCATTGTGCCGTCCTCGCCTCAGCCTCAGCGAGCTCAGCTTGCTCCACACGCCCCCCA
CCCGTCACACCCTCGGCACCCTCACCACCCGCAACACACACCACACTCCTTGCCTTCCCCTGATCCAGAT
ATCCTCTCAGTGTCAAGTTGCCCTGCGCTTTATCGAAATGAAGAGGAGGAAGAGGCCATTTACTTCTCTG
CTGAAAAGCAATGGGAAGTGCCAGACACAGCTTCAGAATGTGACTCCTTAAATTCTTCCATTGGAAGGAA
ACAGTCTCCTCCTTTAAGCCTCGAGATATACCAAACATTATCTCCGCGAAAGATATCAAGAGATGAGGTG
TCCCTAGAGGATTCCTCCCGAGGGGATTCGCCTGTAACTGTGGATGTGTCTTGGGGTTCTCCCGACTGTG
TAGGTCTGACAGAAACTAAGAGTATGATCTTCAGTCCTGCAAGCAAAGTGTACAATGGCATTTTGGAGAA
ATCCTGTAGCATGAACCAGCTTTCCAGTGGCATCCCGGTGCCTAAACCTCGCCACACATCATGTTCCTCA
GCTGGCAACGACAGTAAACCAGTTCAGGAAGCCCCAAGTGTTGCCAGAATAAGCAGCATCCCACATGACC
TTTGTCATAATGGAGAGAAAAGCAAAAAGCCATCAAAAATCAAAAGCCTTTTTAAGAAGAAATCTAAGTG
A

Translation (746 aa):
MLVLGLLVAGAADGCELVPRHLRGRRATGSAATAASSPAAAAGDSPALMTDPCMSLSPPCFTEEDRFSLE
ALQTIHKQMDDDKDGGIEVEESDEFIREDMKYKDATNKHSHLHREDKHITIEDLWKRWKTSEVHNWTLED
TLQWLIEFVELPQYEKNFRDNNVKGTTLPRIAVHEPSFMISQLKISDRSHRQKLQLKALDVVLFGPLTRP
PHNWMKDFILTVSIVIGVGGCWFAYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVA
VEKQNLERKMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDA
LQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKAL
SELTTCLRERLFRWQQIEKICGFQIAHNSGLPSLTSSLYSDHSWVVMPRVSIPPYPIAGGVDDLDEDTPP
IVSQFPGTMAKPPGSLARSSSLCRSRRSIVPSSPQPQRAQLAPHAPHPSHPRHPHHPQHTPHSLPSPDPD
ILSVSSCPALYRNEEEEEAIYFSAEKQWEVPDTASECDSLNSSIGRKQSPPLSLEIYQTLSPRKISRDEV
SLEDSSRGDSPVTVDVSWGSPDCVGLTETKSMIFSPASKVYNGILEKSCSMNQLSSGIPVPKPRHTSCSS
AGNDSKPVQEAPSVARISSIPHDLCHNGEKSKKPSKIKSLFKKKSK


Links Key
 Links to:   History report
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 Re-query CCDS DB by:   CCDS ID
  Gene ID
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 Genome Browser Links:   Ensembl Genome Browser
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