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Genome Displays Related Resources Gene HomoloGene MANE RefSeq
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Report for CCDS3440.2 (current version)
CCDS |
Status |
Species |
Chrom. |
Gene |
CCDS Release |
NCBI Annotation Release |
Ensembl Annotation Release |
Links |
3440.2 |
Public |
Homo sapiens |
4 |
STIM2 |
24 |
110 |
108 |
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Public Note for CCDS 3440.1 |
The coding region has been updated to shorten the N-terminus to one that is more supported by data in PMID:1146333. This publication shows that a non-AUG translation initiation codon is used exclusively. The UUG start codon annotated in the update is conserved as an AUG in rat and mouse. An upstream in-frame putative AUG start codon exists in the transcript, which would result in a protein that is 87 aa longer at the N-terminus, but the studies in PMID:1146333 do not support usage of this. In addition, a signal peptide is predicted only if the downstream start codon is used, and the same publication performed N-terminal sequencing of the mature protein to confirm the signal peptide cleavage. |
Public since: CCDS release 1, NCBI annotation release 35.1, Ensembl annotation release 23
Review status: Reviewed (by RefSeq, Havana and CCDS collaboration)
Attributes |
CDS uses downstream AUG |
Non-AUG initiation codon |
Sequence IDs included in CCDS 3440.2
Original |
Current |
Source |
Nucleotide ID |
Protein ID |
MANE |
Status in CCDS |
Seq. Status |
Links |
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EBI |
ENST00000467087.7 |
ENSP00000419073.2 |
MANE Select |
Accepted |
alive |
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NCBI |
NM_020860.4 |
NP_065911.3 |
MANE Select |
Accepted |
alive |
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RefSeq |
Length |
Related UniProtKB/SwissProt |
Length |
Identity |
Gaps |
Mismatches |
NP_065911.3 |
746 |
Q9P246-1 |
746 |
100% |
0 |
0 |
Chromosomal Locations for CCDS 3440.2
Assembly GRCh38.p14 (GCF_000001405.40)
CCDS Sequence Data |
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Blue highlighting indicates alternating exons. | Red highlighting indicates amino acids encoded across a splice junction. | | Mouse over the nucleotide or protein sequence below and click on the highlighted codon or residue to select the pair. This works on the replacement symbol in the Translation Exceptions section also. |
Translation Exceptions: replace the symbol L (codon TTG) with M at amino acid position 1
Nucleotide Sequence (2241 nt): TTGCTGGTGCTCGGGCTGCTGGTAGCCGGAGCGGCGGACGGATGCGAGCTTGTGCCCCGGCACCTCCGCG GGCGGCGGGCGACTGGCTCTGCCGCAACTGCCGCCTCCTCTCCCGCCGCGGCGGCCGGCGATAGCCCGGC GCTCATGACAGATCCCTGCATGTCACTGAGTCCACCATGCTTTACAGAAGAAGACAGATTTAGTCTGGAA GCTCTTCAAACAATACATAAACAAATGGATGATGACAAAGATGGTGGAATTGAAGTAGAGGAAAGTGATG AATTCATCAGAGAAGATATGAAATATAAAGATGCTACTAATAAACACAGCCATCTGCACAGAGAAGATAA ACATATAACGATTGAGGATTTATGGAAACGATGGAAAACATCAGAAGTTCATAATTGGACCCTTGAAGAC ACTCTTCAGTGGTTGATAGAGTTTGTTGAACTACCCCAATATGAGAAGAATTTTAGAGACAACAATGTCA AAGGAACGACACTTCCCAGGATAGCAGTGCACGAACCTTCATTTATGATCTCCCAGTTGAAAATCAGTGA CCGGAGTCACAGACAAAAACTTCAGCTCAAGGCATTGGATGTGGTTTTGTTTGGACCTCTAACACGCCCA CCTCATAACTGGATGAAAGATTTTATCCTCACAGTTTCTATAGTAATTGGTGTTGGAGGCTGCTGGTTTG CTTATACGCAGAATAAGACATCAAAAGAACATGTTGCAAAAATGATGAAAGATTTAGAGAGCTTACAAAC TGCAGAGCAAAGTCTAATGGACTTACAGGAGAGGCTTGAAAAGGCACAGGAAGAAAACAGAAATGTTGCT GTAGAAAAGCAAAATTTAGAGCGCAAAATGATGGATGAAATCAATTATGCAAAGGAGGAGGCTTGTCGGC TGAGAGAGCTAAGGGAGGGAGCTGAATGTGAATTGAGTAGACGTCAGTATGCAGAACAGGAATTGGAACA GGTTCGCATGGCTCTGAAAAAGGCCGAAAAAGAATTTGAACTGAGAAGCAGTTGGTCTGTTCCAGATGCA CTTCAGAAATGGCTTCAGTTAACACATGAAGTAGAAGTGCAATACTACAATATTAAAAGACAAAACGCTG AAATGCAGCTAGCTATTGCTAAAGATGAGGCAGAAAAAATTAAAAAGAAGAGAAGCACAGTCTTTGGGAC TCTGCACGTTGCACACAGCTCCTCCCTAGATGAGGTAGACCACAAAATTCTGGAAGCAAAGAAAGCTCTC TCTGAGTTGACAACTTGTTTACGAGAACGACTTTTTCGCTGGCAACAAATTGAGAAGATCTGTGGCTTTC AGATAGCCCATAACTCAGGACTCCCCAGCCTGACCTCTTCCCTTTATTCTGATCACAGCTGGGTGGTGAT GCCCAGAGTCTCCATTCCACCCTATCCAATTGCTGGAGGAGTTGATGACTTAGATGAAGACACACCCCCA ATAGTGTCACAATTTCCCGGGACCATGGCTAAACCTCCTGGATCATTAGCCAGAAGCAGCAGCCTGTGCC GTTCACGCCGCAGCATTGTGCCGTCCTCGCCTCAGCCTCAGCGAGCTCAGCTTGCTCCACACGCCCCCCA CCCGTCACACCCTCGGCACCCTCACCACCCGCAACACACACCACACTCCTTGCCTTCCCCTGATCCAGAT ATCCTCTCAGTGTCAAGTTGCCCTGCGCTTTATCGAAATGAAGAGGAGGAAGAGGCCATTTACTTCTCTG CTGAAAAGCAATGGGAAGTGCCAGACACAGCTTCAGAATGTGACTCCTTAAATTCTTCCATTGGAAGGAA ACAGTCTCCTCCTTTAAGCCTCGAGATATACCAAACATTATCTCCGCGAAAGATATCAAGAGATGAGGTG TCCCTAGAGGATTCCTCCCGAGGGGATTCGCCTGTAACTGTGGATGTGTCTTGGGGTTCTCCCGACTGTG TAGGTCTGACAGAAACTAAGAGTATGATCTTCAGTCCTGCAAGCAAAGTGTACAATGGCATTTTGGAGAA ATCCTGTAGCATGAACCAGCTTTCCAGTGGCATCCCGGTGCCTAAACCTCGCCACACATCATGTTCCTCA GCTGGCAACGACAGTAAACCAGTTCAGGAAGCCCCAAGTGTTGCCAGAATAAGCAGCATCCCACATGACC TTTGTCATAATGGAGAGAAAAGCAAAAAGCCATCAAAAATCAAAAGCCTTTTTAAGAAGAAATCTAAGTG A
Translation (746 aa): MLVLGLLVAGAADGCELVPRHLRGRRATGSAATAASSPAAAAGDSPALMTDPCMSLSPPCFTEEDRFSLE ALQTIHKQMDDDKDGGIEVEESDEFIREDMKYKDATNKHSHLHREDKHITIEDLWKRWKTSEVHNWTLED TLQWLIEFVELPQYEKNFRDNNVKGTTLPRIAVHEPSFMISQLKISDRSHRQKLQLKALDVVLFGPLTRP PHNWMKDFILTVSIVIGVGGCWFAYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVA VEKQNLERKMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDA LQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKAL SELTTCLRERLFRWQQIEKICGFQIAHNSGLPSLTSSLYSDHSWVVMPRVSIPPYPIAGGVDDLDEDTPP IVSQFPGTMAKPPGSLARSSSLCRSRRSIVPSSPQPQRAQLAPHAPHPSHPRHPHHPQHTPHSLPSPDPD ILSVSSCPALYRNEEEEEAIYFSAEKQWEVPDTASECDSLNSSIGRKQSPPLSLEIYQTLSPRKISRDEV SLEDSSRGDSPVTVDVSWGSPDCVGLTETKSMIFSPASKVYNGILEKSCSMNQLSSGIPVPKPRHTSCSS AGNDSKPVQEAPSVARISSIPHDLCHNGEKSKKPSKIKSLFKKKSK
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