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Report for CCDS1229.2 (current version)

CCDS Status Species Chrom. Gene CCDS Release NCBI Annotation Release Ensembl Annotation Release Links
1229.2 Public Homo sapiens 1 MPZ 24 110 108 CCDS HistoryNCBI Gene:4359Re-query CCDS DB by CCDS ID:1229.2Re-query CCDS DB by GeneID:4359See the combined annotation on chromosome 1 in Sequence Viewer

Public Note for CCDS 1229.1
The coding region has been updated to shorten the N-terminus to one that is more supported by current research community use. The updated start codon has a stronger Kozak signal and is better conserved across vertebrate species than the previously represented upstream start codon. There is no experimental evidence indicating which start codon is preferentially used in vivo. It is possible that the upstream start codon is used some of the time, whereas leaky scanning by ribosomes will permit use of the downstream start codon more of the time. Both the longer and shorter N-termini have predicted signal peptides (SignalP 3.0), but the signal peptide is 10 aa longer when the upstream start codon is used.

Public since: CCDS release 1, NCBI annotation release 35.1, Ensembl annotation release 23

Review status: Reviewed (by RefSeq, Havana and CCDS collaboration)


Attributes
CDS uses downstream AUG

Sequence IDs included in CCDS 1229.2

Original Current Source Nucleotide ID Protein ID MANE Status in CCDS Seq. Status Links
Original member Current member EBI ENST00000463290.5 ENSP00000431538.1 Accepted alive Link to Ensembl Transcript Viewer:ENST00000463290.5Link to Ensembl Protein Viewer:ENSP00000431538.1Re-query CCDS DB by Nucleotide ID:ENST00000463290Re-query CCDS DB by Protein ID:ENSP00000431538
Original member Current member EBI ENST00000533357.5 ENSP00000432943.1 MANE Select Accepted alive Link to Ensembl Transcript Viewer:ENST00000533357.5Link to Ensembl Protein Viewer:ENSP00000432943.1Re-query CCDS DB by Nucleotide ID:ENST00000533357Re-query CCDS DB by Protein ID:ENSP00000432943
Original member Current member NCBI NM_000530.8 NP_000521.2 MANE Select Accepted alive Link to Nucleotide Sequence:NM_000530.8Link to Protein Sequence:NP_000521.2Re-query CCDS DB by Nucleotide ID:NM_000530Re-query CCDS DB by Protein ID:NP_000521Link to BLAST:NP_000521.2

RefSeq Length Related UniProtKB/SwissProt Length Identity Gaps Mismatches
NP_000521.2 248 P25189-1 248 100% 0 0

Chromosomal Locations for CCDS 1229.2

Assembly GRCh38.p14 (GCF_000001405.40)

On '-' strand of Chromosome 1 (NC_000001.11)
Genome Browser links: Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 1Link to Ensembl Genome Browser on chromosome 1See the combined annotation on chromosome 1 in Sequence Viewer

Chromosome Start Stop Links
1 161305876 161305977 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 1Link to Ensembl Genome Browser on chromosome 1
1 161306108 161306168 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 1Link to Ensembl Genome Browser on chromosome 1
1 161306329 161306464 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 1Link to Ensembl Genome Browser on chromosome 1
1 161306708 161306921 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 1Link to Ensembl Genome Browser on chromosome 1
1 161307258 161307424 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 1Link to Ensembl Genome Browser on chromosome 1
1 161309839 161309905 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 1Link to Ensembl Genome Browser on chromosome 1

CCDS Sequence Data
Blue highlighting indicates alternating exons.
Red highlighting indicates amino acids encoded across a splice junction.
 
Mouse over the nucleotide or protein sequence below and click on the highlighted codon or residue to select the pair.

Nucleotide Sequence (747 nt):
ATGGCTCCTGGGGCTCCCTCATCCAGCCCCAGCCCTATCCTGGCTGTGCTGCTCTTCTCTTCTTTGGTGC
TGTCCCCGGCCCAGGCCATCGTGGTTTACACCGACAGGGAGGTCCATGGTGCTGTGGGCTCCCGGGTGAC
CCTGCACTGCTCCTTCTGGTCCAGTGAGTGGGTCTCAGATGACATCTCCTTCACCTGGCGCTACCAGCCC
GAAGGGGGCAGAGATGCCATTTCGATCTTCCACTATGCCAAGGGACAACCCTACATTGACGAGGTGGGGA
CCTTCAAAGAGCGCATCCAGTGGGTAGGGGACCCTCGCTGGAAGGATGGCTCCATTGTCATACACAACCT
AGACTACAGTGACAATGGCACGTTCACTTGTGACGTCAAAAACCCTCCAGACATAGTGGGCAAGACCTCT
CAGGTCACGCTGTATGTCTTTGAAAAAGTGCCAACTAGGTACGGGGTCGTTCTGGGAGCTGTGATCGGGG
GTGTCCTCGGGGTGGTGCTGTTGCTGCTGCTGCTTTTCTACGTGGTTCGGTACTGCTGGCTACGCAGGCA
GGCGGCCCTGCAGAGGAGGCTCAGTGCTATGGAGAAGGGGAAATTGCACAAGCCAGGAAAGGACGCGTCG
AAGCGCGGGCGGCAGACGCCAGTGCTGTATGCAATGCTGGACCACAGCAGAAGCACCAAAGCTGTCAGTG
AGAAGAAGGCCAAGGGGCTGGGGGAGTCTCGCAAGGATAAGAAATAG

Translation (248 aa):
MAPGAPSSSPSPILAVLLFSSLVLSPAQAIVVYTDREVHGAVGSRVTLHCSFWSSEWVSDDISFTWRYQP
EGGRDAISIFHYAKGQPYIDEVGTFKERIQWVGDPRWKDGSIVIHNLDYSDNGTFTCDVKNPPDIVGKTS
QVTLYVFEKVPTRYGVVLGAVIGGVLGVVLLLLLLFYVVRYCWLRRQAALQRRLSAMEKGKLHKPGKDAS
KRGRQTPVLYAMLDHSRSTKAVSEKKAKGLGESRKDKK


Links Key
 Links to:   History report
  BLAST report
  Entrez Gene
  Nucleotide report
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 Re-query CCDS DB by:   CCDS ID
  Gene ID
  Nucleotide ID
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 Genome Browser Links:   Ensembl Genome Browser
  NCBI Sequence Viewer
  UCSC Genome Browser
  VEGA Genome Browser

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