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Report for CCDS33186.2 (current version)

CCDS Status Species Chrom. Gene CCDS Release NCBI Annotation Release Ensembl Annotation Release Links
33186.2 Public Homo sapiens 2 PKDCC 24 110 108 CCDS HistoryNCBI Gene:91461Re-query CCDS DB by CCDS ID:33186.2See the combined annotation on chromosome 2 in Sequence Viewer

Public Note for CCDS 33186.1
The coding region has been updated to extend the N-terminus to one that is more supported by available conservation data and protein homology and there is no experimental evidence to show which translation start site is preferred. The translation initiation codon is well-conserved among mammals but it has a weak Kozak sequence whereas the downstream AUG has a strong Kozak sequence. Due to leaky scanning, although some ribosomes may initiate translation at the upstream AUG, other ribosomes may skip this AUG codon and initiate at the downstream AUG.

Public since: CCDS release 3, NCBI annotation release 36.2, Ensembl annotation release 41

Review status: Reviewed (by RefSeq, Havana and CCDS collaboration)

Sequence IDs included in CCDS 33186.2

Original Current Source Nucleotide ID Protein ID MANE Status in CCDS Seq. Status Links
Original member Current member EBI ENST00000294964.6 ENSP00000294964.5 MANE Select Accepted alive Link to Ensembl Transcript Viewer:ENST00000294964.6Link to Ensembl Protein Viewer:ENSP00000294964.5Re-query CCDS DB by Nucleotide ID:ENST00000294964Re-query CCDS DB by Protein ID:ENSP00000294964
Original member Current member NCBI NM_138370.3 NP_612379.2 MANE Select Accepted alive Link to Nucleotide Sequence:NM_138370.3Link to Protein Sequence:NP_612379.2Re-query CCDS DB by Nucleotide ID:NM_138370Re-query CCDS DB by Protein ID:NP_612379Link to BLAST:NP_612379.2

RefSeq Length Related UniProtKB/SwissProt Length Identity Gaps Mismatches
NP_612379.2 493 Q504Y2 493 100% 0 0

Chromosomal Locations for CCDS 33186.2

Assembly GRCh38.p14 (GCF_000001405.40)

On '+' strand of Chromosome 2 (NC_000002.12)
Genome Browser links: Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 2Link to Ensembl Genome Browser on chromosome 2See the combined annotation on chromosome 2 in Sequence Viewer

Chromosome Start Stop Links
2 42048200 42048838 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 2Link to Ensembl Genome Browser on chromosome 2
2 42053239 42053361 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 2Link to Ensembl Genome Browser on chromosome 2
2 42054036 42054307 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 2Link to Ensembl Genome Browser on chromosome 2
2 42054941 42055020 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 2Link to Ensembl Genome Browser on chromosome 2
2 42055286 42055393 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 2Link to Ensembl Genome Browser on chromosome 2
2 42057221 42057394 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 2Link to Ensembl Genome Browser on chromosome 2
2 42057603 42057688 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 2Link to Ensembl Genome Browser on chromosome 2

CCDS Sequence Data
Blue highlighting indicates alternating exons.
Red highlighting indicates amino acids encoded across a splice junction.
 
Mouse over the nucleotide or protein sequence below and click on the highlighted codon or residue to select the pair.

Nucleotide Sequence (1482 nt):
ATGCGGCGCCGGCGGGCGGCAGTGGCCGCGGGTTTCTGCGCCTCCTTCCTGCTGGGCTCCGTCCTCAACG
TGCTCTTCGCTCCGGGCTCGGAGCCTCCGAGGCCAGGCCAGTCCCCTGAGCCTTCGCCGGCCCCGGGTCC
GGGCCGTCGCGGGGGCCGCGGGGAGCTGGCCCGGCAGATCCGGGCGCGCTACGAGGAGGTGCAGCGCTAT
TCCCGCGGGGGCCCCGGGCCCGGGGCGGGCCGGCCGGAGCGGCGGCGCCTGATGGACCTGGCTCCGGGCG
GGCCCGGCCTGCCGCGCCCCCGGCCCCCTTGGGCCCGGCCCCTGTCCGACGGCGCCCCAGGCTGGCCCCC
GGCTCCCGGCCCAGGCTCCCCCGGCCCGGGCCCGCGCCTGGGCTGCGCCGCGCTTCGCAACGTGTCCGGC
GCGCAGTACATGGGCTCAGGCTACACCAAGGCCGTGTACCGGGTCCGCCTGCCCGGCGGTGCCGCGGTGG
CGCTCAAGGCGGTGGACTTTAGCGGCCACGATCTGGGCAGCTGCGTGCGCGAGTTCGGGGTACGGAGGGG
CTGCTATCGGCTGGCGGCCCACAAGCTGCTTAAGGAGATGGTGCTGCTGGAGCGGCTGCGGCACCCCAAC
GTGCTGCAGCTCTATGGCTACTGCTACCAGGACAGCGAGGACATCCCAGACACCCTGACCACCATCACGG
AGCTGGGCGCCCCTGTAGAAATGATCCAGCTGCTGCAAACTTCCTGGGAGGATCGATTCCGAATCTGCCT
GAGCCTGGGCCGCCTCCTCCACCACCTGGCCCACTCCCCACTGGGCTCCGTCACTCTGCTGGACTTCCGC
CCTCGGCAGTTTGTGCTGGTGGATGGGGAGCTCAAAGTGACGGACCTGGATGACGCACGTGTGGAGGAGA
CGCCGTGTGCAGGCAGCACCGACTGCATACTCGAGTTTCCGGCCAGGAACTTCACCCTGCCCTGCTCAGC
CCAGGGCTGGTGCGAGGGCATGAACGAGAAGCGGAACCTCTATAATGCCTACAGGTTTTTCTTCACATAC
CTCCTGCCTCACAGTGCCCCGCCTTCACTGCGTCCTCTGCTGGACAGCATCGTCAACGCCACAGGAGAGC
TCGCCTGGGGGGTGGACGAGACCCTGGCCCAGCTGGAGAAGGTGCTGCACCTGTACCGGAGCGGGCAGTA
TCTGCAGAACTCCACGGCAAGCAGCAGTACCGAGTACCAGTGTATCCCAGACAGCACCATCCCCCAGGAA
GACTACCGCTGCTGGCCATCCTACCACCACGGGAGCTGCCTCCTTTCAGTGTTCAACCTGGCTGAGGCTG
TGGATGTCTGTGAGAGCCATGCCCAGTGTCGGGCCTTTGTGGTCACCAACCAGACCACCTGGACAGGTCG
GCAGCTGGTCTTTTTCAAGACTGGATGGAGCCAAGTGGTCCCTGATCCCAACAAGACCACATATGTGAAG
GCCTCTGGCTGA

Translation (493 aa):
MRRRRAAVAAGFCASFLLGSVLNVLFAPGSEPPRPGQSPEPSPAPGPGRRGGRGELARQIRARYEEVQRY
SRGGPGPGAGRPERRRLMDLAPGGPGLPRPRPPWARPLSDGAPGWPPAPGPGSPGPGPRLGCAALRNVSG
AQYMGSGYTKAVYRVRLPGGAAVALKAVDFSGHDLGSCVREFGVRRGCYRLAAHKLLKEMVLLERLRHPN
VLQLYGYCYQDSEDIPDTLTTITELGAPVEMIQLLQTSWEDRFRICLSLGRLLHHLAHSPLGSVTLLDFR
PRQFVLVDGELKVTDLDDARVEETPCAGSTDCILEFPARNFTLPCSAQGWCEGMNEKRNLYNAYRFFFTY
LLPHSAPPSLRPLLDSIVNATGELAWGVDETLAQLEKVLHLYRSGQYLQNSTASSSTEYQCIPDSTIPQE
DYRCWPSYHHGSCLLSVFNLAEAVDVCESHAQCRAFVVTNQTTWTGRQLVFFKTGWSQVVPDPNKTTYVK
ASG


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 Links to:   History report
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 Genome Browser Links:   Ensembl Genome Browser
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