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Report for CCDS369.2 (current version)

CCDS Status Species Chrom. Gene CCDS Release NCBI Annotation Release Ensembl Annotation Release Links
369.2 Public Homo sapiens 1 FNDC5 24 110 108 CCDS HistoryNCBI Gene:252995Re-query CCDS DB by CCDS ID:369.2Re-query CCDS DB by GeneID:252995See the combined annotation on chromosome 1 in Sequence Viewer

Public Note for CCDS 369.1
The coding region has been updated to extend the N-terminus to one that is more supported by the available protein, conservation and publication data. The updated CCDS representation uses a non-AUG (AUA) start codon. The human AUA start codon is conserved as AUG in most other mammals, and the use of this start codon results in a longer protein with an N-terminal signal peptide, consistent with experimental evidence showing that it is secreted (PMID:22237023).

Public since: CCDS release 1, NCBI annotation release 35.1, Ensembl annotation release 23

Review status: Reviewed (by RefSeq, Havana and CCDS collaboration)


Attributes
CDS uses downstream AUG
Non-AUG initiation codon

Sequence IDs included in CCDS 369.2

Original Current Source Nucleotide ID Protein ID MANE Status in CCDS Seq. Status Links
Original member Current member EBI ENST00000373471.9 ENSP00000362570.5 MANE Select Accepted alive Link to Ensembl Transcript Viewer:ENST00000373471.9Link to Ensembl Protein Viewer:ENSP00000362570.5Re-query CCDS DB by Nucleotide ID:ENST00000373471Re-query CCDS DB by Protein ID:ENSP00000362570
Original member Current member NCBI NM_153756.3 NP_715637.2 MANE Select Accepted alive Link to Nucleotide Sequence:NM_153756.3Link to Protein Sequence:NP_715637.2Re-query CCDS DB by Nucleotide ID:NM_153756Re-query CCDS DB by Protein ID:NP_715637Link to BLAST:NP_715637.2

RefSeq Length Related UniProtKB/SwissProt Length Identity Gaps Mismatches
NP_715637.2 212 Q8NAU1-1 212 100% 0 0

Chromosomal Locations for CCDS 369.2

Assembly GRCh38.p14 (GCF_000001405.40)

On '-' strand of Chromosome 1 (NC_000001.11)
Genome Browser links: Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 1Link to Ensembl Genome Browser on chromosome 1See the combined annotation on chromosome 1 in Sequence Viewer

Chromosome Start Stop Links
1 32864294 32864299 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 1Link to Ensembl Genome Browser on chromosome 1
1 32864664 32864797 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 1Link to Ensembl Genome Browser on chromosome 1
1 32867753 32867842 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 1Link to Ensembl Genome Browser on chromosome 1
1 32868190 32868388 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 1Link to Ensembl Genome Browser on chromosome 1
1 32868882 32868997 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 1Link to Ensembl Genome Browser on chromosome 1
1 32870653 32870746 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 1Link to Ensembl Genome Browser on chromosome 1

CCDS Sequence Data
Blue highlighting indicates alternating exons.
Red highlighting indicates amino acids encoded across a splice junction.
 
Mouse over the nucleotide or protein sequence below and click on the highlighted codon or residue to select the pair. This works on the replacement symbol in the Translation Exceptions section also.

Translation Exceptions:
replace the symbol I (codon ATA) with M at amino acid position 1

Nucleotide Sequence (639 nt):
ATACACCCCGGGTCGCCGAGCGCCTGGCCGCCCCGCGCCCGCGCCGCGCTCCGCCTGTGGCTGGGCTGCG
TCTGCTTCGCGCTGGTGCAGGCGGACAGTCCCTCAGCCCCAGTGAACGTCACCGTCAGGCACCTCAAGGC
CAACTCTGCAGTGGTGAGCTGGGATGTTCTGGAGGATGAGGTTGTCATCGGATTTGCCATCTCCCAGCAG
AAGAAGGATGTGCGGATGCTGCGCTTCATCCAGGAGGTGAACACCACCACCCGCTCATGTGCCCTCTGGG
ACCTGGAGGAGGATACGGAGTACATAGTCCACGTGCAGGCCATCTCCATTCAGGGCCAGAGCCCAGCCAG
CGAGCCTGTGCTCTTCAAGACCCCGCGTGAGGCTGAGAAGATGGCCTCCAAGAACAAAGATGAGGTAACC
ATGAAAGAGATGGGGAGGAACCAACAGCTGCGGACAGGCGAGGTGCTGATCATCGTCGTGGTCCTGTTCA
TGTGGGCAGGTGTCATTGCCCTCTTCTGCCGCCAGTATGACATCATCAAGGACAATGAACCCAATAACAA
CAAGGAAAAAACCAAGAGTGCATCAGAAACCAGCACACCAGAGCACCAGGGCGGGGGGCTTCTCCGCAGC
AAGATATGA

Translation (212 aa):
MHPGSPSAWPPRARAALRLWLGCVCFALVQADSPSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAISQQ
KKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQGQSPASEPVLFKTPREAEKMASKNKDEVT
MKEMGRNQQLRTGEVLIIVVVLFMWAGVIALFCRQYDIIKDNEPNNNKEKTKSASETSTPEHQGGGLLRS
KI


Links Key
 Links to:   History report
  BLAST report
  Entrez Gene
  Nucleotide report
  Protein report
 Re-query CCDS DB by:   CCDS ID
  Gene ID
  Nucleotide ID
  Protein ID
 Genome Browser Links:   Ensembl Genome Browser
  NCBI Sequence Viewer
  UCSC Genome Browser
  VEGA Genome Browser

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