NCBI Iterated profile searches with PSI-BLAST CSH


Figure 1

Alignment of a predicted novel archaeal DNA ligase with yeast DNA ligase II. The alignment is taken directly from the second PSI-BLAST iteration. The motifs conserved in DNA ligases [20] are shown in red, and the catalytic lysine is indicated by an asterisk.


[20] Shuman, S. & Schwer, B. (1995) "RNA capping enzyme and DNA ligase: a superfamily of covalent nucleotidyl transferases." Mol. Microbiol. 17:405-410. (PubMed)