LPGAT1 controls MEGDEL syndrome by coupling phosphatidylglycerol remodeling with mitochondrial transport.
Cell Rep.
2023 Nov 28;42(11):113214. doi: 10.1016/j.celrep.2023.113214. Epub 2023 Nov 2. PubMed PMID:
37917582; PubMed Central PMCID:
PMC10729602.
Aster-B coordinates with Arf1 to regulate mitochondrial cholesterol transport.
Mol Metab.
2020 Dec;42:101055. doi: 10.1016/j.molmet.2020.101055. Epub 2020 Jul 29. PubMed PMID:
32738348; PubMed Central PMCID:
PMC7476871.
Aster-C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1.
EMBO Rep.
2020 Sep 3;21(9):e49898. doi: 10.15252/embr.201949898. Epub 2020 Jul 9. PubMed PMID:
32648345; PubMed Central PMCID:
PMC7507422.
Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson's diseases.
Aging Cell.
2019 Jun;18(3):e12941. doi: 10.1111/acel.12941. Epub 2019 Mar 5. PubMed PMID:
30838774; PubMed Central PMCID:
PMC6516155.
Defective Phosphatidylglycerol Remodeling Causes Hepatopathy, Linking Mitochondrial Dysfunction to Hepatosteatosis.
Cell Mol Gastroenterol Hepatol.
2019;7(4):763-781. doi: 10.1016/j.jcmgh.2019.02.002. Epub 2019 Mar 1. PubMed PMID:
30831319; PubMed Central PMCID:
PMC6463126.
SAD-A Promotes Glucose-Stimulated Insulin Secretion Through Phosphorylation and Inhibition of GDIα in Male Islet β Cells.
Endocrinology.
2018 Aug 1;159(8):3036-3047. doi: 10.1210/en.2017-03243. PubMed PMID:
29873699; PubMed Central PMCID:
PMC6693047.
Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20.
Nat Commun.
2017 Mar 22;8:14824. doi: 10.1038/ncomms14824. PubMed PMID:
28327662; PubMed Central PMCID:
PMC5364431.
Regulation of autophagy by mitochondrial phospholipids in health and diseases.
Biochim Biophys Acta Mol Cell Biol Lipids.
2017 Jan;1862(1):114-129. doi: 10.1016/j.bbalip.2016.08.003. Epub 2016 Aug 5. Review. PubMed PMID:
27502688; PubMed Central PMCID:
PMC7707390.
ZBTB20 is required for anterior pituitary development and lactotrope specification.
Nat Commun.
2016 Apr 15;7:11121. doi: 10.1038/ncomms11121. PubMed PMID:
27079169; PubMed Central PMCID:
PMC4835541.
Bif-1 deficiency impairs lipid homeostasis and causes obesity accompanied by insulin resistance.
Sci Rep.
2016 Feb 9;6:20453. doi: 10.1038/srep20453. PubMed PMID:
26857140; PubMed Central PMCID:
PMC4746598.
Knockin of Cre Gene at Ins2 Locus Reveals No Cre Activity in Mouse Hypothalamic Neurons.
Sci Rep.
2016 Feb 2;6:20438. doi: 10.1038/srep20438. PubMed PMID:
26830324; PubMed Central PMCID:
PMC4735843.
Transcription factor Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in rodent models.
Diabetologia.
2016 Feb;59(2):316-24. doi: 10.1007/s00125-015-3805-3. Epub 2015 Nov 12. PubMed PMID:
26564177.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy.
2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. PubMed PMID:
26799652; PubMed Central PMCID:
PMC4835977.
Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy.
Autophagy.
2015 Apr 3;11(4):643-52. doi: 10.1080/15548627.2015.1023984. PubMed PMID:
25919711; PubMed Central PMCID:
PMC4502692.
ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis.
Hepatology.
2015 Feb;61(2):486-96. doi: 10.1002/hep.27420. PubMed PMID:
25203315; PubMed Central PMCID:
PMC4303512.
Discovery of Novel Anti-Diabetic Drugs by Targeting Lipid Metabolism.
Curr Drug Targets.
2015;16(12):1372-80. doi: 10.2174/1389450116666150223120829. Review. PubMed PMID:
25706109.
A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2α.
J Biol Chem.
2014 Dec 26;289(52):36284-302. doi: 10.1074/jbc.M114.620922. Epub 2014 Nov 12. PubMed PMID:
25391657; PubMed Central PMCID:
PMC4276889.
Comparative gene identification-58 (CGI-58) promotes autophagy as a putative lysophosphatidylglycerol acyltransferase.
J Biol Chem.
2014 Nov 21;289(47):33044-53. doi: 10.1074/jbc.M114.573857. Epub 2014 Oct 14. PubMed PMID:
25315780; PubMed Central PMCID:
PMC4239649.
Monoacylglycerol acyltransferase-2 is a tetrameric enzyme that selectively heterodimerizes with diacylglycerol acyltransferase-1.
J Biol Chem.
2014 Apr 11;289(15):10909-10918. doi: 10.1074/jbc.M113.530022. Epub 2014 Feb 25. PubMed PMID:
24573674; PubMed Central PMCID:
PMC4036202.
SAD-A and AMPK kinases: the "yin and yang" regulators of mTORC1 signaling in pancreatic β cells.
Cell Cycle.
2013 Nov 1;12(21):3366-9. doi: 10.4161/cc.26496. Epub 2013 Sep 18. PubMed PMID:
24047693; PubMed Central PMCID:
PMC3895425.
MicroRNA-24/MODY gene regulatory pathway mediates pancreatic β-cell dysfunction.
Diabetes.
2013 Sep;62(9):3194-206. doi: 10.2337/db13-0151. Epub 2013 Jun 12. PubMed PMID:
23761103; PubMed Central PMCID:
PMC3749364.
SAD-A kinase controls islet β-cell size and function as a mediator of mTORC1 signaling.
Proc Natl Acad Sci U S A.
2013 Aug 20;110(34):13857-62. doi: 10.1073/pnas.1307698110. Epub 2013 Aug 6. PubMed PMID:
23922392; PubMed Central PMCID:
PMC3752253.
SAD-A potentiates glucose-stimulated insulin secretion as a mediator of glucagon-like peptide 1 response in pancreatic β cells.
Mol Cell Biol.
2013 Jul;33(13):2527-34. doi: 10.1128/MCB.00285-13. Epub 2013 Apr 29. PubMed PMID:
23629625; PubMed Central PMCID:
PMC3700116.
Inactivation of MARK4, an AMP-activated protein kinase (AMPK)-related kinase, leads to insulin hypersensitivity and resistance to diet-induced obesity.
J Biol Chem.
2012 Nov 2;287(45):38305-15. doi: 10.1074/jbc.M112.388934. Epub 2012 Sep 19. PubMed PMID:
22992738; PubMed Central PMCID:
PMC3488099.
Ablation of ALCAT1 mitigates hypertrophic cardiomyopathy through effects on oxidative stress and mitophagy.
Mol Cell Biol.
2012 Nov;32(21):4493-504. doi: 10.1128/MCB.01092-12. Epub 2012 Sep 4. PubMed PMID:
22949503; PubMed Central PMCID:
PMC3486149.
Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells.
J Biol Chem.
2012 Jul 27;287(31):26435-44. doi: 10.1074/jbc.M112.378372. Epub 2012 Jun 5. PubMed PMID:
22669945; PubMed Central PMCID:
PMC3406726.
Targeted inactivation of GPR26 leads to hyperphagia and adiposity by activating AMPK in the hypothalamus.
PLoS One.
2012;7(7):e40764. doi: 10.1371/journal.pone.0040764. Epub 2012 Jul 16. PubMed PMID:
22815809; PubMed Central PMCID:
PMC3398048.
Lysocardiolipin acyltransferase 1 (ALCAT1) controls mitochondrial DNA fidelity and biogenesis through modulation of MFN2 expression.
Proc Natl Acad Sci U S A.
2012 May 1;109(18):6975-80. doi: 10.1073/pnas.1120043109. Epub 2012 Apr 16. PubMed PMID:
22509026; PubMed Central PMCID:
PMC3345005.
Inhibition of the receptor for advanced glycation endproducts (RAGE) protects pancreatic β-cells.
Biochem Biophys Res Commun.
2011 Jan 7;404(1):159-65. doi: 10.1016/j.bbrc.2010.11.085. Epub 2010 Nov 25. PubMed PMID:
21111711; NIHMSID:NIHMS454028.
Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity.
Cell Metab.
2010 Aug 4;12(2):154-65. doi: 10.1016/j.cmet.2010.07.003. PubMed PMID:
20674860; PubMed Central PMCID:
PMC2923392.
A novel function of the human CLS1 in phosphatidylglycerol synthesis and remodeling.
Biochim Biophys Acta.
2010 Apr;1801(4):438-45. doi: 10.1016/j.bbalip.2009.12.002. Epub 2009 Dec 16. PubMed PMID:
20025994; PubMed Central PMCID:
PMC2830748.
Emerging roles of cardiolipin remodeling in mitochondrial dysfunction associated with diabetes, obesity, and cardiovascular diseases.
J Biomed Res.
2010 Jan;24(1):6-15. doi: 10.1016/S1674-8301(10)60003-6. PubMed PMID:
23554606; PubMed Central PMCID:
PMC3596530.
A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.
Am J Physiol Endocrinol Metab.
2009 Dec;297(6):E1276-82. doi: 10.1152/ajpendo.00475.2009. Epub 2009 Sep 22. PubMed PMID:
19773578; PubMed Central PMCID:
PMC2793047.
Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism.
Am J Physiol Endocrinol Metab.
2009 Jul;297(1):E10-8. doi: 10.1152/ajpendo.90949.2008. Epub 2008 Dec 30. Review. PubMed PMID:
19116371; PubMed Central PMCID:
PMC3735925.
ALCAT1 is a polyglycerophospholipid acyltransferase potently regulated by adenine nucleotide and thyroid status.
Am J Physiol Endocrinol Metab.
2009 Apr;296(4):E647-53. doi: 10.1152/ajpendo.90761.2008. Epub 2008 Dec 23. PubMed PMID:
19106248; PubMed Central PMCID:
PMC3734525.
CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation.
J Cell Biol.
2008 Jun 16;181(6):959-72. doi: 10.1083/jcb.200711044. Epub 2008 Jun 9. PubMed PMID:
18541707; PubMed Central PMCID:
PMC2426947.
Phospholipid scramblase-3 regulates cardiolipin de novo biosynthesis and its resynthesis in growing HeLa cells.
Biochem J.
2007 Jan 1;401(1):103-9. doi: 10.1042/BJ20060373. PubMed PMID:
16939411; PubMed Central PMCID:
PMC1698660.
Identification and functional characterization of hCLS1, a human cardiolipin synthase localized in mitochondria.
Biochem J.
2006 Sep 1;398(2):169-76. doi: 10.1042/BJ20060303. PubMed PMID:
16716149; PubMed Central PMCID:
PMC1550299.
Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells.
Biochem J.
2005 May 15;388(Pt 1):135-42. doi: 10.1042/BJ20041554. PubMed PMID:
15610069; PubMed Central PMCID:
PMC1186701.
Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus.
J Exp Med.
1994 Aug 1;180(2):595-606. doi: 10.1084/jem.180.2.595. PubMed PMID:
7519242; PubMed Central PMCID:
PMC2191592.
Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65.
J Cell Biol.
1994 Mar;124(6):927-34. doi: 10.1083/jcb.124.6.927. PubMed PMID:
8132714; PubMed Central PMCID:
PMC2119982.
Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase.
Proc Natl Acad Sci U S A.
1993 Apr 1;90(7):2832-6. doi: 10.1073/pnas.90.7.2832. PubMed PMID:
7681990; PubMed Central PMCID:
PMC46190.
Coordinate expression of ribosomal protein genes in Neurospora crassa and identification of conserved upstream sequences.
Nucleic Acids Res.
1991 Dec 11;19(23):6511-7. doi: 10.1093/nar/19.23.6511. PubMed PMID:
1836561; PubMed Central PMCID:
PMC329209.
Pyrrolidine, a non-controlled substance, can replace piperidine for the chemical sequencing of DNA.
Nucleic Acids Res.
1989 Apr 25;17(8):3317. doi: 10.1093/nar/17.8.3317. PubMed PMID:
2726479; PubMed Central PMCID:
PMC317756.
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