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Sun H, Zhang J, Ye Q, Jiang T, Liu X, Zhang X, Zeng F, Li J, Zheng Y, Han X, Su C, Shi Y. LPGAT1 controls MEGDEL syndrome by coupling phosphatidylglycerol remodeling with mitochondrial transport. Cell Rep. 2023 Nov 28;42(11):113214. doi: 10.1016/j.celrep.2023.113214. Epub 2023 Nov 2. PubMed PMID: 37917582; PubMed Central PMCID: PMC10729602.
Andersen JP, Zhang J, Sun H, Liu X, Liu J, Nie J, Shi Y. Aster-B coordinates with Arf1 to regulate mitochondrial cholesterol transport. Mol Metab. 2020 Dec;42:101055. doi: 10.1016/j.molmet.2020.101055. Epub 2020 Jul 29. PubMed PMID: 32738348; PubMed Central PMCID: PMC7476871.
Zhang J, Andersen JP, Sun H, Liu X, Sonenberg N, Nie J, Shi Y. Aster-C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1. EMBO Rep. 2020 Sep 3;21(9):e49898. doi: 10.15252/embr.201949898. Epub 2020 Jul 9. PubMed PMID: 32648345; PubMed Central PMCID: PMC7507422.
Song C, Zhang J, Qi S, Liu Z, Zhang X, Zheng Y, Andersen JP, Zhang W, Strong R, Martinez PA, Musi N, Nie J, Shi Y. Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson's diseases. Aging Cell. 2019 Jun;18(3):e12941. doi: 10.1111/acel.12941. Epub 2019 Mar 5. PubMed PMID: 30838774; PubMed Central PMCID: PMC6516155.
Zhang X, Zhang J, Sun H, Liu X, Zheng Y, Xu D, Wang J, Jia D, Han X, Liu F, Nie J, Shi Y. Defective Phosphatidylglycerol Remodeling Causes Hepatopathy, Linking Mitochondrial Dysfunction to Hepatosteatosis. Cell Mol Gastroenterol Hepatol. 2019;7(4):763-781. doi: 10.1016/j.jcmgh.2019.02.002. Epub 2019 Mar 1. PubMed PMID: 30831319; PubMed Central PMCID: PMC6463126.
Nie J, Sun C, Chang Z, Musi N, Shi Y. SAD-A Promotes Glucose-Stimulated Insulin Secretion Through Phosphorylation and Inhibition of GDIα in Male Islet β Cells. Endocrinology. 2018 Aug 1;159(8):3036-3047. doi: 10.1210/en.2017-03243. PubMed PMID: 29873699; PubMed Central PMCID: PMC6693047.
Liu G, Zhou L, Zhang H, Chen R, Zhang Y, Li L, Lu JY, Jiang H, Liu D, Qi S, Jiang YM, Yin K, Xie Z, Shi Y, Liu Y, Cao X, Chen YX, Zou D, Zhang WJ. Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20. Nat Commun. 2017 Mar 22;8:14824. doi: 10.1038/ncomms14824. PubMed PMID: 28327662; PubMed Central PMCID: PMC5364431.
Hsu P, Shi Y. Regulation of autophagy by mitochondrial phospholipids in health and diseases. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Jan;1862(1):114-129. doi: 10.1016/j.bbalip.2016.08.003. Epub 2016 Aug 5. Review. PubMed PMID: 27502688; PubMed Central PMCID: PMC7707390.
Cao D, Ma X, Cai J, Luan J, Liu AJ, Yang R, Cao Y, Zhu X, Zhang H, Chen YX, Shi Y, Shi GX, Zou D, Cao X, Grusby MJ, Xie Z, Zhang WJ. ZBTB20 is required for anterior pituitary development and lactotrope specification. Nat Commun. 2016 Apr 15;7:11121. doi: 10.1038/ncomms11121. PubMed PMID: 27079169; PubMed Central PMCID: PMC4835541.
Liu Y, Takahashi Y, Desai N, Zhang J, Serfass JM, Shi YG, Lynch CJ, Wang HG. Bif-1 deficiency impairs lipid homeostasis and causes obesity accompanied by insulin resistance. Sci Rep. 2016 Feb 9;6:20453. doi: 10.1038/srep20453. PubMed PMID: 26857140; PubMed Central PMCID: PMC4746598.
Li L, Gao L, Wang K, Ma X, Chang X, Shi JH, Zhang Y, Yin K, Liu Z, Shi Y, Xie Z, Zhang WJ. Knockin of Cre Gene at Ins2 Locus Reveals No Cre Activity in Mouse Hypothalamic Neurons. Sci Rep. 2016 Feb 2;6:20438. doi: 10.1038/srep20438. PubMed PMID: 26830324; PubMed Central PMCID: PMC4735843.
Chen F, Sha M, Wang Y, Wu T, Shan W, Liu J, Zhou W, Zhu Y, Sun Y, Shi Y, Bleich D, Han X. Transcription factor Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in rodent models. Diabetologia. 2016 Feb;59(2):316-24. doi: 10.1007/s00125-015-3805-3. Epub 2015 Nov 12. PubMed PMID: 26564177.
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Nie J, Han X, Shi Y. SAD-A and AMPK kinases: the "yin and yang" regulators of mTORC1 signaling in pancreatic β cells. Cell Cycle. 2013 Nov 1;12(21):3366-9. doi: 10.4161/cc.26496. Epub 2013 Sep 18. PubMed PMID: 24047693; PubMed Central PMCID: PMC3895425.
Zhu Y, You W, Wang H, Li Y, Qiao N, Shi Y, Zhang C, Bleich D, Han X. MicroRNA-24/MODY gene regulatory pathway mediates pancreatic β-cell dysfunction. Diabetes. 2013 Sep;62(9):3194-206. doi: 10.2337/db13-0151. Epub 2013 Jun 12. PubMed PMID: 23761103; PubMed Central PMCID: PMC3749364.
Nie J, Liu X, Lilley BN, Zhang H, Pan YA, Kimball SR, Zhang J, Zhang W, Wang L, Jefferson LS, Sanes JR, Han X, Shi Y. SAD-A kinase controls islet β-cell size and function as a mediator of mTORC1 signaling. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13857-62. doi: 10.1073/pnas.1307698110. Epub 2013 Aug 6. PubMed PMID: 23922392; PubMed Central PMCID: PMC3752253.
Nie J, Lilley BN, Pan YA, Faruque O, Liu X, Zhang W, Sanes JR, Han X, Shi Y. SAD-A potentiates glucose-stimulated insulin secretion as a mediator of glucagon-like peptide 1 response in pancreatic β cells. Mol Cell Biol. 2013 Jul;33(13):2527-34. doi: 10.1128/MCB.00285-13. Epub 2013 Apr 29. PubMed PMID: 23629625; PubMed Central PMCID: PMC3700116.
Sun C, Tian L, Nie J, Zhang H, Han X, Shi Y. Inactivation of MARK4, an AMP-activated protein kinase (AMPK)-related kinase, leads to insulin hypersensitivity and resistance to diet-induced obesity. J Biol Chem. 2012 Nov 2;287(45):38305-15. doi: 10.1074/jbc.M112.388934. Epub 2012 Sep 19. PubMed PMID: 22992738; PubMed Central PMCID: PMC3488099.
Liu X, Ye B, Miller S, Yuan H, Zhang H, Tian L, Nie J, Imae R, Arai H, Li Y, Cheng Z, Shi Y. Ablation of ALCAT1 mitigates hypertrophic cardiomyopathy through effects on oxidative stress and mitophagy. Mol Cell Biol. 2012 Nov;32(21):4493-504. doi: 10.1128/MCB.01092-12. Epub 2012 Sep 4. PubMed PMID: 22949503; PubMed Central PMCID: PMC3486149.
Nie J, Sun C, Faruque O, Ye G, Li J, Liang Q, Chang Z, Yang W, Han X, Shi Y. Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells. J Biol Chem. 2012 Jul 27;287(31):26435-44. doi: 10.1074/jbc.M112.378372. Epub 2012 Jun 5. PubMed PMID: 22669945; PubMed Central PMCID: PMC3406726.
Chen D, Liu X, Zhang W, Shi Y. Targeted inactivation of GPR26 leads to hyperphagia and adiposity by activating AMPK in the hypothalamus. PLoS One. 2012;7(7):e40764. doi: 10.1371/journal.pone.0040764. Epub 2012 Jul 16. PubMed PMID: 22815809; PubMed Central PMCID: PMC3398048.
Li J, Liu X, Wang H, Zhang W, Chan DC, Shi Y. Lysocardiolipin acyltransferase 1 (ALCAT1) controls mitochondrial DNA fidelity and biogenesis through modulation of MFN2 expression. Proc Natl Acad Sci U S A. 2012 May 1;109(18):6975-80. doi: 10.1073/pnas.1120043109. Epub 2012 Apr 16. PubMed PMID: 22509026; PubMed Central PMCID: PMC3345005.
Zhu Y, Shu T, Lin Y, Wang H, Yang J, Shi Y, Han X. Inhibition of the receptor for advanced glycation endproducts (RAGE) protects pancreatic β-cells. Biochem Biophys Res Commun. 2011 Jan 7;404(1):159-65. doi: 10.1016/j.bbrc.2010.11.085. Epub 2010 Nov 25. PubMed PMID: 21111711; NIHMSID:NIHMS454028.
Li J, Romestaing C, Han X, Li Y, Hao X, Wu Y, Sun C, Liu X, Jefferson LS, Xiong J, Lanoue KF, Chang Z, Lynch CJ, Wang H, Shi Y. Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity. Cell Metab. 2010 Aug 4;12(2):154-65. doi: 10.1016/j.cmet.2010.07.003. PubMed PMID: 20674860; PubMed Central PMCID: PMC2923392.
Nie J, Hao X, Chen D, Han X, Chang Z, Shi Y. A novel function of the human CLS1 in phosphatidylglycerol synthesis and remodeling. Biochim Biophys Acta. 2010 Apr;1801(4):438-45. doi: 10.1016/j.bbalip.2009.12.002. Epub 2009 Dec 16. PubMed PMID: 20025994; PubMed Central PMCID: PMC2830748.
Shi Y. Emerging roles of cardiolipin remodeling in mitochondrial dysfunction associated with diabetes, obesity, and cardiovascular diseases. J Biomed Res. 2010 Jan;24(1):6-15. doi: 10.1016/S1674-8301(10)60003-6. PubMed PMID: 23554606; PubMed Central PMCID: PMC3596530.
Cheng L, Han X, Shi Y. A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice. Am J Physiol Endocrinol Metab. 2009 Dec;297(6):E1276-82. doi: 10.1152/ajpendo.00475.2009. Epub 2009 Sep 22. PubMed PMID: 19773578; PubMed Central PMCID: PMC2793047.
Shi Y, Cheng D. Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism. Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E10-8. doi: 10.1152/ajpendo.90949.2008. Epub 2008 Dec 30. Review. PubMed PMID: 19116371; PubMed Central PMCID: PMC3735925.
Cao J, Shen W, Chang Z, Shi Y. ALCAT1 is a polyglycerophospholipid acyltransferase potently regulated by adenine nucleotide and thyroid status. Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E647-53. doi: 10.1152/ajpendo.90761.2008. Epub 2008 Dec 23. PubMed PMID: 19106248; PubMed Central PMCID: PMC3734525.
Li X, Huang M, Zheng H, Wang Y, Ren F, Shang Y, Zhai Y, Irwin DM, Shi Y, Chen D, Chang Z. CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation. J Cell Biol. 2008 Jun 16;181(6):959-72. doi: 10.1083/jcb.200711044. Epub 2008 Jun 9. PubMed PMID: 18541707; PubMed Central PMCID: PMC2426947.
Van Q, Liu J, Lu B, Feingold KR, Shi Y, Lee RM, Hatch GM. Phospholipid scramblase-3 regulates cardiolipin de novo biosynthesis and its resynthesis in growing HeLa cells. Biochem J. 2007 Jan 1;401(1):103-9. doi: 10.1042/BJ20060373. PubMed PMID: 16939411; PubMed Central PMCID: PMC1698660.
Chen D, Zhang XY, Shi Y. Identification and functional characterization of hCLS1, a human cardiolipin synthase localized in mitochondria. Biochem J. 2006 Sep 1;398(2):169-76. doi: 10.1042/BJ20060303. PubMed PMID: 16716149; PubMed Central PMCID: PMC1550299.
Zhang S, Yang Y, Shi Y. Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells. Biochem J. 2005 May 15;388(Pt 1):135-42. doi: 10.1042/BJ20041554. PubMed PMID: 15610069; PubMed Central PMCID: PMC1186701.
Kim J, Namchuk M, Bugawan T, Fu Q, Jaffe M, Shi Y, Aanstoot HJ, Turck CW, Erlich H, Lennon V, Baekkeskov S. Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus. J Exp Med. 1994 Aug 1;180(2):595-606. doi: 10.1084/jem.180.2.595. PubMed PMID: 7519242; PubMed Central PMCID: PMC2191592.
Shi Y, Veit B, Baekkeskov S. Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65. J Cell Biol. 1994 Mar;124(6):927-34. doi: 10.1083/jcb.124.6.927. PubMed PMID: 8132714; PubMed Central PMCID: PMC2119982.
Richter W, Shi Y, Baekkeskov S. Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase. Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2832-6. doi: 10.1073/pnas.90.7.2832. PubMed PMID: 7681990; PubMed Central PMCID: PMC46190.
Shi YG, Tyler BM. Coordinate expression of ribosomal protein genes in Neurospora crassa and identification of conserved upstream sequences. Nucleic Acids Res. 1991 Dec 11;19(23):6511-7. doi: 10.1093/nar/19.23.6511. PubMed PMID: 1836561; PubMed Central PMCID: PMC329209.
Shi YG, Tyler BM. Pyrrolidine, a non-controlled substance, can replace piperidine for the chemical sequencing of DNA. Nucleic Acids Res. 1989 Apr 25;17(8):3317. doi: 10.1093/nar/17.8.3317. PubMed PMID: 2726479; PubMed Central PMCID: PMC317756.
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