Metabolic footprint and logic through the T cell life cycle.
Curr Opin Immunol.
2024 Sep 21;91:102487. doi: 10.1016/j.coi.2024.102487. [Epub ahead of print] Review. PubMed PMID:
39307123; NIHMSID:NIHMS2025361.
Tonic-ing emissions and compatibility to turbocharge CAR-T.
Nat Metab.
2024 Jun;6(6):990-992. doi: 10.1038/s42255-024-01022-x. PubMed PMID:
38658804.
Selective refueling of CAR T cells using ADA1 and CD26 boosts antitumor immunity.
Cell Rep Med.
2024 May 21;5(5):101530. doi: 10.1016/j.xcrm.2024.101530. Epub 2024 Apr 29. PubMed PMID:
38688275; PubMed Central PMCID:
PMC11148642.
RBM39 degrader invigorates natural killer cells to eradicate neuroblastoma despite cancer cell plasticity.
bioRxiv.
2024 Mar 25;. doi: 10.1101/2024.03.21.586157. PubMed PMID:
38585889; PubMed Central PMCID:
PMC10996557.
Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor.
Elife.
2024 Mar 15;12. doi: 10.7554/eLife.90993. PubMed PMID:
38488852; PubMed Central PMCID:
PMC10942784.
Conditional c-MYC activation in catecholaminergic cells drives distinct neuroendocrine tumors: neuroblastoma vs somatostatinoma.
bioRxiv.
2024 Mar 14;. doi: 10.1101/2024.03.12.584622. PubMed PMID:
38559042; PubMed Central PMCID:
PMC10980015.
Asparagine restriction enhances CD8(+) T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response.
Nat Metab.
2023 Aug;5(8):1423-1439. doi: 10.1038/s42255-023-00856-1. Epub 2023 Aug 7. PubMed PMID:
37550596; PubMed Central PMCID:
PMC10447245.
Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma.
Nat Commun.
2023 Jul 6;14(1):4003. doi: 10.1038/s41467-023-39717-6. PubMed PMID:
37414763; PubMed Central PMCID:
PMC10326052.
CD200R signaling contributes to unfavorable tumor microenvironment through regulating production of chemokines by tumor-associated myeloid cells.
iScience.
2023 Jun 16;26(6):106904. doi: 10.1016/j.isci.2023.106904. eCollection 2023 Jun 16. PubMed PMID:
37275530; PubMed Central PMCID:
PMC10239067.
Apoptotic cell death in disease-Current understanding of the NCCD 2023.
Cell Death Differ.
2023 May;30(5):1097-1154. doi: 10.1038/s41418-023-01153-w. Epub 2023 Apr 26. Review. PubMed PMID:
37100955; PubMed Central PMCID:
PMC10130819.
The lactate dehydrogenase (LDH) isoenzyme spectrum enables optimally controlling T cell glycolysis and differentiation.
Sci Adv.
2023 Mar 24;9(12):eadd9554. doi: 10.1126/sciadv.add9554. Epub 2023 Mar 24. PubMed PMID:
36961904; PubMed Central PMCID:
PMC10038341.
GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation.
Nat Metab.
2022 Oct;4(10):1322-1335. doi: 10.1038/s42255-022-00638-1. Epub 2022 Oct 3. PubMed PMID:
36192601; PubMed Central PMCID:
PMC9584824.
Revisiting the multisite phosphorylation that produces the M-phase supershift of key mitotic regulators.
Mol Biol Cell.
2022 Oct 1;33(12):ar115. doi: 10.1091/mbc.E22-04-0118. Epub 2022 Aug 17. PubMed PMID:
35976701; PubMed Central PMCID:
PMC9635296.
Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor-mediated synergistic antileukemic actions.
Sci Adv.
2022 Sep 16;8(37):eabp9005. doi: 10.1126/sciadv.abp9005. Epub 2022 Sep 16. PubMed PMID:
36112677; PubMed Central PMCID:
PMC9481139.
Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma.
Sci Transl Med.
2022 Jul 13;14(653):eabq2096. doi: 10.1126/scitranslmed.abq2096. Epub 2022 Jul 13. PubMed PMID:
35857643; PubMed Central PMCID:
PMC9548378.
Biphasic response of T cell to asparagine-restriction maximizes its metabolic fitness and anti-tumoral functionality.
bioRxiv. 2022 July.
Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation.
Sci Immunol.
2022 Apr 29;7(70):eabm8161. doi: 10.1126/sciimmunol.abm8161. Epub 2022 Apr 29. PubMed PMID:
35486677; PubMed Central PMCID:
PMC9332111.
Splice-switching of the insulin receptor pre-mRNA alleviates tumorigenic hallmarks in rhabdomyosarcoma.
NPJ Precis Oncol.
2022 Jan 11;6(1):1. doi: 10.1038/s41698-021-00245-5. PubMed PMID:
35017650; PubMed Central PMCID:
PMC8752779.
The Goldilocks Principle conferred by LDH isoenzymes controls T cell glycolysis and differentiation.
bioRxiv. 2022 January.
NAD(+) supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells.
Cell Rep.
2021 Aug 10;36(6):109516. doi: 10.1016/j.celrep.2021.109516. PubMed PMID:
34380043.
A Simple and Robust Protocol for in vitro Differentiation of Mouse Non-pathogenic T Helper 17 Cells from CD4(+) T Cells.
Bio Protoc.
2021 May 20;11(10):e4029. doi: 10.21769/BioProtoc.4029. eCollection 2021 May 20. PubMed PMID:
34150936; PubMed Central PMCID:
PMC8187118.
The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer.
Cell Mol Immunol.
2021 Apr;18(4):1074-1076. doi: 10.1038/s41423-020-00610-7. Epub 2021 Jan 18. PubMed PMID:
33462382; PubMed Central PMCID:
PMC8115558.
De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function.
Sci Adv.
2020 Dec;6(51). doi: 10.1126/sciadv.abc4275. Print 2020 Dec. PubMed PMID:
33328226; PubMed Central PMCID:
PMC7744078.
CD4(+)CD126(low/-) Foxp3(+) Cell Population Represents a Superior Subset of Regulatory T Cells in Treating Autoimmune Diseases.
Mol Ther.
2020 Nov 4;28(11):2406-2416. doi: 10.1016/j.ymthe.2020.07.020. Epub 2020 Jul 21. PubMed PMID:
32738192; PubMed Central PMCID:
PMC7647671.
Rapid profiling of G2 phase to mitosis progression by flow cytometry in asynchronous cells.
Cell Cycle.
2020 Nov;19(21):2897-2905. doi: 10.1080/15384101.2020.1827510. Epub 2020 Oct 10. PubMed PMID:
33043808; PubMed Central PMCID:
PMC7714512.
Dynamic metabolic reprogramming in dendritic cells: An early response to influenza infection that is essential for effector function.
PLoS Pathog.
2020 Oct;16(10):e1008957. doi: 10.1371/journal.ppat.1008957. eCollection 2020 Oct. PubMed PMID:
33104753; PubMed Central PMCID:
PMC7707590.
Inosine is an alternative carbon source for CD8(+)-T-cell function under glucose restriction.
Nat Metab.
2020 Jul;2(7):635-647. doi: 10.1038/s42255-020-0219-4. Epub 2020 Jun 15. PubMed PMID:
32694789; PubMed Central PMCID:
PMC7371628.
Radioisotope-Based Protocol for Determination of Central Carbon Metabolism in T Cells.
Methods Mol Biol.
2020;2111:257-265. doi: 10.1007/978-1-0716-0266-9_20. PubMed PMID:
31933213.
Immunotherapeutic Challenges for Pediatric Cancers.
Mol Ther Oncolytics.
2019 Dec 20;15:38-48. doi: 10.1016/j.omto.2019.08.005. eCollection 2019 Dec 20. Review. PubMed PMID:
31650024; PubMed Central PMCID:
PMC6804520.
The Antiviral Apparatus: STING and Oncolytic Virus Restriction.
Mol Ther Oncolytics.
2019 Jun 28;13:7-13. doi: 10.1016/j.omto.2019.02.002. eCollection 2019 Jun 28. Review. PubMed PMID:
30989105; PubMed Central PMCID:
PMC6447737.
A Metabolism Toolbox for CAR T Therapy.
Front Oncol.
2019;9:322. doi: 10.3389/fonc.2019.00322. eCollection 2019. Review. PubMed PMID:
31114756; PubMed Central PMCID:
PMC6503740.
Akt-1 and Akt-2 Differentially Regulate the Development of Experimental Autoimmune Encephalomyelitis by Controlling Proliferation of Thymus-Derived Regulatory T Cells.
J Immunol.
2019 Mar 1;202(5):1441-1452. doi: 10.4049/jimmunol.1701204. Epub 2019 Jan 28. PubMed PMID:
30692211; PubMed Central PMCID:
PMC6382580.
mTOR Is Key to T Cell Transdifferentiation.
Cell Metab.
2019 Feb 5;29(2):241-242. doi: 10.1016/j.cmet.2019.01.008. PubMed PMID:
30726756; PubMed Central PMCID:
PMC6556472.
Education-dependent activation of glycolysis promotes the cytolytic potency of licensed human natural killer cells.
J Allergy Clin Immunol.
2019 Jan;143(1):346-358.e6. doi: 10.1016/j.jaci.2018.06.047. Epub 2018 Aug 7. PubMed PMID:
30096390.
Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation.
Elife.
2018 Sep 10;7. doi: 10.7554/eLife.36158. PubMed PMID:
30198844; PubMed Central PMCID:
PMC6152796.
Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1α-dependent glycolysis.
Cell Mol Immunol.
2018 Jun;15(6):618-629. doi: 10.1038/cmi.2017.5. Epub 2017 Mar 13. PubMed PMID:
28287112; PubMed Central PMCID:
PMC6079089.
Metabolic Reprogramming in Modulating T Cell Reactive Oxygen Species Generation and Antioxidant Capacity.
Front Immunol.
2018;9:1075. doi: 10.3389/fimmu.2018.01075. eCollection 2018. Review. PubMed PMID:
29868027; PubMed Central PMCID:
PMC5964129.
Phosphorylation of CDC25C by AMP-activated protein kinase mediates a metabolic checkpoint during cell-cycle G(2)/M-phase transition.
J Biol Chem.
2018 Apr 6;293(14):5185-5199. doi: 10.1074/jbc.RA117.001379. Epub 2018 Feb 21. PubMed PMID:
29467227; PubMed Central PMCID:
PMC5892595.
MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent.
Cell Death Dis.
2018 Feb 14;9(2):220. doi: 10.1038/s41419-018-0295-5. PubMed PMID:
29445162; PubMed Central PMCID:
PMC5833827.
Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox.
Cancer Res.
2017 Sep 1;77(17):4626-4638. doi: 10.1158/0008-5472.CAN-16-0826. Epub 2017 Jul 6. PubMed PMID:
28684529; PubMed Central PMCID:
PMC5581701.
Rapid Profiling Cell Cycle by Flow Cytometry Using Concurrent Staining of DNA and Mitotic Markers.
Bio Protoc.
2017 Aug 20;7(16). doi: 10.21769/BioProtoc.2517. PubMed PMID:
28868333; PubMed Central PMCID:
PMC5580980.
Efficient Codelivery of Paclitaxel and Curcumin by Novel Bottlebrush Copolymer-based Micelles.
Mol Pharm.
2017 Jul 3;14(7):2378-2389. doi: 10.1021/acs.molpharmaceut.7b00278. Epub 2017 Jun 20. PubMed PMID:
28605595.
MYC and HIF in shaping immune response and immune metabolism.
Cytokine Growth Factor Rev.
2017 Jun;35:63-70. doi: 10.1016/j.cytogfr.2017.03.004. Epub 2017 Mar 23. Review. PubMed PMID:
28363691.
MYC in Regulating Immunity: Metabolism and Beyond.
Genes (Basel).
2017 Feb 25;8(3). doi: 10.3390/genes8030088. Review. PubMed PMID:
28245597; PubMed Central PMCID:
PMC5368692.
MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-κB.
Cell Rep.
2016 Oct 4;17(2):514-526. doi: 10.1016/j.celrep.2016.09.010. PubMed PMID:
27705798; PubMed Central PMCID:
PMC5059110.
Metabolic maintenance of cell asymmetry following division in activated T lymphocytes.
Nature.
2016 Apr 21;532(7599):389-93. doi: 10.1038/nature17442. Epub 2016 Apr 11. PubMed PMID:
27064903; PubMed Central PMCID:
PMC4851250.
Proinflammatory signal suppresses proliferation and shifts macrophage metabolism from Myc-dependent to HIF1α-dependent.
Proc Natl Acad Sci U S A.
2016 Feb 9;113(6):1564-9. doi: 10.1073/pnas.1518000113. Epub 2016 Jan 25. PubMed PMID:
26811453; PubMed Central PMCID:
PMC4760828.
Phosphorylation-Dependent Activation of the ESCRT Function of ALIX in Cytokinetic Abscission and Retroviral Budding.
Dev Cell.
2016 Feb 8;36(3):331-43. doi: 10.1016/j.devcel.2016.01.001. PubMed PMID:
26859355; PubMed Central PMCID:
PMC4762455.
Persistent GP130/STAT3 Signaling Contributes to the Resistance of Doxorubicin, Cisplatin, and MEK Inhibitor in Human Rhabdomyosarcoma Cells.
Curr Cancer Drug Targets.
2016;16(7):631-8. doi: 10.2174/1568009615666150916093110. PubMed PMID:
26373715; PubMed Central PMCID:
PMC5014400.
Metabolic Regulation of Immunity.
In:
Kelley & Firestein’s Textbook of Rheumatology
10th ed. USA: Elsevier Press; 2016.
What would you like to do?