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Fan T, Shah R, Wang R. Metabolic footprint and logic through the T cell life cycle. Curr Opin Immunol. 2024 Sep 21;91:102487. doi: 10.1016/j.coi.2024.102487. [Epub ahead of print] Review. PubMed PMID: 39307123; NIHMSID:NIHMS2025361.
Wang H, Huang Y, Wang R. Tonic-ing emissions and compatibility to turbocharge CAR-T. Nat Metab. 2024 Jun;6(6):990-992. doi: 10.1038/s42255-024-01022-x. PubMed PMID: 38658804.
Hu Y, Sarkar A, Song K, Michael S, Hook M, Wang R, Heczey A, Song X. Selective refueling of CAR T cells using ADA1 and CD26 boosts antitumor immunity. Cell Rep Med. 2024 May 21;5(5):101530. doi: 10.1016/j.xcrm.2024.101530. Epub 2024 Apr 29. PubMed PMID: 38688275; PubMed Central PMCID: PMC11148642.
Singh S, Fang J, Jin H, Van de Velde LA, Wu Q, Cortes A, Morton CL, Woolard MA, Quarni W, Steele JA, Connelly JP, He L, Thorne R, Turner G, Confer T, Johnson M, Caufield WV, Freeman BB, Lockey T, Pruett-Miller SM, Wang R, Davidoff AM, Thomas PG, Yang J. RBM39 degrader invigorates natural killer cells to eradicate neuroblastoma despite cancer cell plasticity. bioRxiv. 2024 Mar 25;. doi: 10.1101/2024.03.21.586157. PubMed PMID: 38585889; PubMed Central PMCID: PMC10996557.
Jablonowski CM, Quarni W, Singh S, Tan H, Bostanthirige DH, Jin H, Fang J, Chang TC, Finkelstein D, Cho JH, Hu D, Pagala V, Sakurada SM, Pruett-Miller SM, Wang R, Murphy A, Freeman K, Peng J, Davidoff AM, Wu G, Yang J. Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor. Elife. 2024 Mar 15;12. doi: 10.7554/eLife.90993. PubMed PMID: 38488852; PubMed Central PMCID: PMC10942784.
Wang T, Liu L, Fang J, Jin H, Natarajan S, Sheppard H, Lu M, Turner G, Confer T, Johnson M, Steinberg J, Ha L, Yadak N, Jain R, Picketts DJ, Ma X, Murphy A, Davidoff AM, Glazer ES, Easton J, Chen X, Wang R, Yang J. Conditional c-MYC activation in catecholaminergic cells drives distinct neuroendocrine tumors: neuroblastoma vs somatostatinoma. bioRxiv. 2024 Mar 14;. doi: 10.1101/2024.03.12.584622. PubMed PMID: 38559042; PubMed Central PMCID: PMC10980015.
Gnanaprakasam JNR, Kushwaha B, Liu L, Chen X, Kang S, Wang T, Cassel TA, Adams CM, Higashi RM, Scott DA, Xin G, Li Z, Yang J, Lane AN, Fan TW, Zhang J, Wang R. Asparagine restriction enhances CD8(+) T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response. Nat Metab. 2023 Aug;5(8):1423-1439. doi: 10.1038/s42255-023-00856-1. Epub 2023 Aug 7. PubMed PMID: 37550596; PubMed Central PMCID: PMC10447245.
Fang J, Singh S, Cheng C, Natarajan S, Sheppard H, Abu-Zaid A, Durbin AD, Lee HW, Wu Q, Steele J, Connelly JP, Jin H, Chen W, Fan Y, Pruett-Miller SM, Rehg JE, Koo SC, Santiago T, Emmons J, Cairo S, Wang R, Glazer ES, Murphy AJ, Chen T, Davidoff AM, Armengol C, Easton J, Chen X, Yang J. Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma. Nat Commun. 2023 Jul 6;14(1):4003. doi: 10.1038/s41467-023-39717-6. PubMed PMID: 37414763; PubMed Central PMCID: PMC10326052.
Lin CH, Talebian F, Li Y, Zhu J, Liu JQ, Zhao B, Basu S, Pan X, Chen X, Yan P, Carson WE, Xin G, Wen H, Wang R, Li Z, Ma Q, Bai XF. CD200R signaling contributes to unfavorable tumor microenvironment through regulating production of chemokines by tumor-associated myeloid cells. iScience. 2023 Jun 16;26(6):106904. doi: 10.1016/j.isci.2023.106904. eCollection 2023 Jun 16. PubMed PMID: 37275530; PubMed Central PMCID: PMC10239067.
Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, Balachandran S, Bano D, Barlev NA, Bartek J, Bazan NG, Becker C, Bernassola F, Bertrand MJM, Bianchi ME, Blagosklonny MV, Blander JM, Blandino G, Blomgren K, Borner C, Bortner CD, Bove P, Boya P, Brenner C, Broz P, Brunner T, Damgaard RB, Calin GA, Campanella M, Candi E, Carbone M, Carmona-Gutierrez D, Cecconi F, Chan FK, Chen GQ, Chen Q, Chen YH, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Ciliberto G, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Daugaard M, Dawson TM, Dawson VL, De Maria R, De Strooper B, Debatin KM, Deberardinis RJ, Degterev A, Del Sal G, Deshmukh M, Di Virgilio F, Diederich M, Dixon SJ, Dynlacht BD, El-Deiry WS, Elrod JW, Engeland K, Fimia GM, Galassi C, Ganini C, Garcia-Saez AJ, Garg AD, Garrido C, Gavathiotis E, Gerlic M, Ghosh S, Green DR, Greene LA, Gronemeyer H, Häcker G, Hajnóczky G, Hardwick JM, Haupt Y, He S, Heery DM, Hengartner MO, Hetz C, Hildeman DA, Ichijo H, Inoue S, Jäättelä M, Janic A, Joseph B, Jost PJ, Kanneganti TD, Karin M, Kashkar H, Kaufmann T, Kelly GL, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Kluck R, Krysko DV, Kulms D, Kumar S, Lavandero S, Lavrik IN, Lemasters JJ, Liccardi G, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Luedde T, MacFarlane M, Madeo F, Malorni W, Manic G, Mantovani R, Marchi S, Marine JC, Martin SJ, Martinou JC, Mastroberardino PG, Medema JP, Mehlen P, Meier P, Melino G, Melino S, Miao EA, Moll UM, Muñoz-Pinedo C, Murphy DJ, Niklison-Chirou MV, Novelli F, Núñez G, Oberst A, Ofengeim D, Opferman JT, Oren M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pentimalli F, Pereira DM, Pervaiz S, Peter ME, Pinton P, Porta G, Prehn JHM, Puthalakath H, Rabinovich GA, Rajalingam K, Ravichandran KS, Rehm M, Ricci JE, Rizzuto R, Robinson N, Rodrigues CMP, Rotblat B, Rothlin CV, Rubinsztein DC, Rudel T, Rufini A, Ryan KM, Sarosiek KA, Sawa A, Sayan E, Schroder K, Scorrano L, Sesti F, Shao F, Shi Y, Sica GS, Silke J, Simon HU, Sistigu A, Stephanou A, Stockwell BR, Strapazzon F, Strasser A, Sun L, Sun E, Sun Q, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Troy CM, Turk B, Urbano N, Vandenabeele P, Vanden Berghe T, Vander Heiden MG, Vanderluit JL, Verkhratsky A, Villunger A, von Karstedt S, Voss AK, Vousden KH, Vucic D, Vuri D, Wagner EF, Walczak H, Wallach D, Wang R, Wang Y, Weber A, Wood W, Yamazaki T, Yang HT, Zakeri Z, Zawacka-Pankau JE, Zhang L, Zhang H, Zhivotovsky B, Zhou W, Piacentini M, Kroemer G, Galluzzi L. Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death Differ. 2023 May;30(5):1097-1154. doi: 10.1038/s41418-023-01153-w. Epub 2023 Apr 26. Review. PubMed PMID: 37100955; PubMed Central PMCID: PMC10130819.
Chen X, Liu L, Kang S, Gnanaprakasam JR, Wang R. The lactate dehydrogenase (LDH) isoenzyme spectrum enables optimally controlling T cell glycolysis and differentiation. Sci Adv. 2023 Mar 24;9(12):eadd9554. doi: 10.1126/sciadv.add9554. Epub 2023 Mar 24. PubMed PMID: 36961904; PubMed Central PMCID: PMC10038341.
Kang S, Liu L, Wang T, Cannon M, Lin P, Fan TW, Scott DA, Wu HJ, Lane AN, Wang R. GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation. Nat Metab. 2022 Oct;4(10):1322-1335. doi: 10.1038/s42255-022-00638-1. Epub 2022 Oct 3. PubMed PMID: 36192601; PubMed Central PMCID: PMC9584824.
Tan T, Wu C, Liu B, Pan BF, Hawke DH, Su Z, Liu S, Zhang W, Wang R, Lin SH, Kuang J. Revisiting the multisite phosphorylation that produces the M-phase supershift of key mitotic regulators. Mol Biol Cell. 2022 Oct 1;33(12):ar115. doi: 10.1091/mbc.E22-04-0118. Epub 2022 Aug 17. PubMed PMID: 35976701; PubMed Central PMCID: PMC9635296.
Zhang P, Brinton LT, Gharghabi M, Sher S, Williams K, Cannon M, Walker JS, Canfield D, Beaver L, Cempre CB, Phillips H, Chen X, Yan P, Lehman A, Scherle P, Wang M, Vaddi K, Baiocchi R, Wang R, Sampath D, Alinari L, Blachly JS, Lapalombella R. Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor-mediated synergistic antileukemic actions. Sci Adv. 2022 Sep 16;8(37):eabp9005. doi: 10.1126/sciadv.abp9005. Epub 2022 Sep 16. PubMed PMID: 36112677; PubMed Central PMCID: PMC9481139.
Singh S, Abu-Zaid A, Jin H, Fang J, Wu Q, Wang T, Feng H, Quarni W, Shao Y, Maxham L, Abdolvahabi A, Yun MK, Vaithiyalingam S, Tan H, Bowling J, Honnell V, Young B, Guo Y, Bajpai R, Pruett-Miller SM, Grosveld GC, Hatley M, Xu B, Fan Y, Wu G, Chen EY, Chen T, Lewis PW, Rankovic Z, Li Y, Murphy AJ, Easton J, Peng J, Chen X, Wang R, White SW, Davidoff AM, Yang J. Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma. Sci Transl Med. 2022 Jul 13;14(653):eabq2096. doi: 10.1126/scitranslmed.abq2096. Epub 2022 Jul 13. PubMed PMID: 35857643; PubMed Central PMCID: PMC9548378.
Gnanaprakasam J, Liu L, Chen X, Cassel T, Scott D, Lane A, Fan T, Zhang J, Wang R. Biphasic response of T cell to asparagine-restriction maximizes its metabolic fitness and anti-tumoral functionality. bioRxiv. 2022 July.
Chen X, Sunkel B, Wang M, Kang S, Wang T, Gnanaprakasam JNR, Liu L, Cassel TA, Scott DA, Muñoz-Cabello AM, Lopez-Barneo J, Yang J, Lane AN, Xin G, Stanton BZ, Fan TW, Wang R. Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation. Sci Immunol. 2022 Apr 29;7(70):eabm8161. doi: 10.1126/sciimmunol.abm8161. Epub 2022 Apr 29. PubMed PMID: 35486677; PubMed Central PMCID: PMC9332111.
Khurshid S, Montes M, Comiskey DF Jr, Shane B, Matsa E, Jung F, Brown C, Bid HK, Wang R, Houghton PJ, Roberts R, Rigo F, Chandler D. Splice-switching of the insulin receptor pre-mRNA alleviates tumorigenic hallmarks in rhabdomyosarcoma. NPJ Precis Oncol. 2022 Jan 11;6(1):1. doi: 10.1038/s41698-021-00245-5. PubMed PMID: 35017650; PubMed Central PMCID: PMC8752779.
Chen X, Liu L, Wang R. The Goldilocks Principle conferred by LDH isoenzymes controls T cell glycolysis and differentiation. bioRxiv. 2022 January.
Wang Y, Wang F, Wang L, Qiu S, Yao Y, Yan C, Xiong X, Chen X, Ji Q, Cao J, Gao G, Li D, Zhang L, Guo Z, Wang R, Wang H, Fan G. NAD(+) supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells. Cell Rep. 2021 Aug 10;36(6):109516. doi: 10.1016/j.celrep.2021.109516. PubMed PMID: 34380043.
Kang S, Wu R, Wang R. A Simple and Robust Protocol for in vitro Differentiation of Mouse Non-pathogenic T Helper 17 Cells from CD4(+) T Cells. Bio Protoc. 2021 May 20;11(10):e4029. doi: 10.21769/BioProtoc.4029. eCollection 2021 May 20. PubMed PMID: 34150936; PubMed Central PMCID: PMC8187118.
Jia A, Wang Y, Wang Y, Li Y, Yang Q, Cao Y, He Y, Dong L, Dong Y, Hou Y, Wang R, Bi Y, Liu G. The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer. Cell Mol Immunol. 2021 Apr;18(4):1074-1076. doi: 10.1038/s41423-020-00610-7. Epub 2021 Jan 18. PubMed PMID: 33462382; PubMed Central PMCID: PMC8115558.
Wu R, Chen X, Kang S, Wang T, Gnanaprakasam JR, Yao Y, Liu L, Fan G, Burns MR, Wang R. De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function. Sci Adv. 2020 Dec;6(51). doi: 10.1126/sciadv.abc4275. Print 2020 Dec. PubMed PMID: 33328226; PubMed Central PMCID: PMC7744078.
Chen Y, Xu Z, Liang R, Wang J, Xu A, Na N, Li B, Wang R, Joseph M, Olsen N, Hsueh W, Zheng SG. CD4(+)CD126(low/-) Foxp3(+) Cell Population Represents a Superior Subset of Regulatory T Cells in Treating Autoimmune Diseases. Mol Ther. 2020 Nov 4;28(11):2406-2416. doi: 10.1016/j.ymthe.2020.07.020. Epub 2020 Jul 21. PubMed PMID: 32738192; PubMed Central PMCID: PMC7647671.
Sherman J, Wang R. Rapid profiling of G2 phase to mitosis progression by flow cytometry in asynchronous cells. Cell Cycle. 2020 Nov;19(21):2897-2905. doi: 10.1080/15384101.2020.1827510. Epub 2020 Oct 10. PubMed PMID: 33043808; PubMed Central PMCID: PMC7714512.
Rezinciuc S, Bezavada L, Bahadoran A, Duan S, Wang R, Lopez-Ferrer D, Finkelstein D, McGargill MA, Green DR, Pasa-Tolic L, Smallwood HS. Dynamic metabolic reprogramming in dendritic cells: An early response to influenza infection that is essential for effector function. PLoS Pathog. 2020 Oct;16(10):e1008957. doi: 10.1371/journal.ppat.1008957. eCollection 2020 Oct. PubMed PMID: 33104753; PubMed Central PMCID: PMC7707590.
Wang T, Gnanaprakasam JNR, Chen X, Kang S, Xu X, Sun H, Liu L, Rodgers H, Miller E, Cassel TA, Sun Q, Vicente-Muñoz S, Warmoes MO, Lin P, Piedra-Quintero ZL, Guerau-de-Arellano M, Cassady KA, Zheng SG, Yang J, Lane AN, Song X, Fan TW, Wang R. Inosine is an alternative carbon source for CD8(+)-T-cell function under glucose restriction. Nat Metab. 2020 Jul;2(7):635-647. doi: 10.1038/s42255-020-0219-4. Epub 2020 Jun 15. PubMed PMID: 32694789; PubMed Central PMCID: PMC7371628.
Chen X, Sherman JW, Wang R. Radioisotope-Based Protocol for Determination of Central Carbon Metabolism in T Cells. Methods Mol Biol. 2020;2111:257-265. doi: 10.1007/978-1-0716-0266-9_20. PubMed PMID: 31933213.
Hutzen B, Ghonime M, Lee J, Mardis ER, Wang R, Lee DA, Cairo MS, Roberts RD, Cripe TP, Cassady KA. Immunotherapeutic Challenges for Pediatric Cancers. Mol Ther Oncolytics. 2019 Dec 20;15:38-48. doi: 10.1016/j.omto.2019.08.005. eCollection 2019 Dec 20. Review. PubMed PMID: 31650024; PubMed Central PMCID: PMC6804520.
Lee J, Ghonime MG, Wang R, Cassady KA. The Antiviral Apparatus: STING and Oncolytic Virus Restriction. Mol Ther Oncolytics. 2019 Jun 28;13:7-13. doi: 10.1016/j.omto.2019.02.002. eCollection 2019 Jun 28. Review. PubMed PMID: 30989105; PubMed Central PMCID: PMC6447737.
Xu X, Gnanaprakasam JNR, Sherman J, Wang R. A Metabolism Toolbox for CAR T Therapy. Front Oncol. 2019;9:322. doi: 10.3389/fonc.2019.00322. eCollection 2019. Review. PubMed PMID: 31114756; PubMed Central PMCID: PMC6503740.
Ouyang S, Zeng Q, Tang N, Guo H, Tang R, Yin W, Wang A, Tang H, Zhou J, Xie H, Langdon WY, Yang H, Zhang J. Akt-1 and Akt-2 Differentially Regulate the Development of Experimental Autoimmune Encephalomyelitis by Controlling Proliferation of Thymus-Derived Regulatory T Cells. J Immunol. 2019 Mar 1;202(5):1441-1452. doi: 10.4049/jimmunol.1701204. Epub 2019 Jan 28. PubMed PMID: 30692211; PubMed Central PMCID: PMC6382580.
Yan J, Wang R, Horng T. mTOR Is Key to T Cell Transdifferentiation. Cell Metab. 2019 Feb 5;29(2):241-242. doi: 10.1016/j.cmet.2019.01.008. PubMed PMID: 30726756; PubMed Central PMCID: PMC6556472.
Schafer JR, Salzillo TC, Chakravarti N, Kararoudi MN, Trikha P, Foltz JA, Wang R, Li S, Lee DA. Education-dependent activation of glycolysis promotes the cytolytic potency of licensed human natural killer cells. J Allergy Clin Immunol. 2019 Jan;143(1):346-358.e6. doi: 10.1016/j.jaci.2018.06.047. Epub 2018 Aug 7. PubMed PMID: 30096390.
Lian G, Gnanaprakasam JR, Wang T, Wu R, Chen X, Liu L, Shen Y, Yang M, Yang J, Chen Y, Vasiliou V, Cassel TA, Green DR, Liu Y, Fan TW, Wang R. Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation. Elife. 2018 Sep 10;7. doi: 10.7554/eLife.36158. PubMed PMID: 30198844; PubMed Central PMCID: PMC6152796.
Lu Y, Liu H, Bi Y, Yang H, Li Y, Wang J, Zhang Z, Wang Y, Li C, Jia A, Han L, Hu Y, Zhao Y, Wang R, Liu G. Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1α-dependent glycolysis. Cell Mol Immunol. 2018 Jun;15(6):618-629. doi: 10.1038/cmi.2017.5. Epub 2017 Mar 13. PubMed PMID: 28287112; PubMed Central PMCID: PMC6079089.
Rashida Gnanaprakasam JN, Wu R, Wang R. Metabolic Reprogramming in Modulating T Cell Reactive Oxygen Species Generation and Antioxidant Capacity. Front Immunol. 2018;9:1075. doi: 10.3389/fimmu.2018.01075. eCollection 2018. Review. PubMed PMID: 29868027; PubMed Central PMCID: PMC5964129.
Shen Y, Sherman JW, Chen X, Wang R. Phosphorylation of CDC25C by AMP-activated protein kinase mediates a metabolic checkpoint during cell-cycle G(2)/M-phase transition. J Biol Chem. 2018 Apr 6;293(14):5185-5199. doi: 10.1074/jbc.RA117.001379. Epub 2018 Feb 21. PubMed PMID: 29467227; PubMed Central PMCID: PMC5892595.
Wang T, Liu L, Chen X, Shen Y, Lian G, Shah N, Davidoff AM, Yang J, Wang R. MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent. Cell Death Dis. 2018 Feb 14;9(2):220. doi: 10.1038/s41419-018-0295-5. PubMed PMID: 29445162; PubMed Central PMCID: PMC5833827.
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Yao Q, Gutierrez DC, Hoang NH, Kim D, Wang R, Hobbs C, Zhu L. Efficient Codelivery of Paclitaxel and Curcumin by Novel Bottlebrush Copolymer-based Micelles. Mol Pharm. 2017 Jul 3;14(7):2378-2389. doi: 10.1021/acs.molpharmaceut.7b00278. Epub 2017 Jun 20. PubMed PMID: 28605595.
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