My Bibliography

select

Park JE, Kim TS, Zeng Y, Mikolaj M, Il Ahn J, Alam MS, Monnie CM, Shi V, Zhou M, Chun TW, Maldarelli F, Narayan K, Ahn J, Ashwell JD, Strebel K, Lee KS. Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4(+) T cells. Nat Commun. 2024 Mar 5;15(1):2017. doi: 10.1038/s41467-024-46306-8. PubMed PMID: 38443376; PubMed Central PMCID: PMC10914751.

select

Park JE, Kirsch K, Lee H, Oliva P, Ahn JI, Ravishankar H, Zeng Y, Fox SD, Kirby SA, Badhwar P, Andresson T, Jacobson KA, Lee KS. Specific inhibition of an anticancer target, polo-like kinase 1, by allosterically dismantling its mechanism of substrate recognition. Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2305037120. doi: 10.1073/pnas.2305037120. Epub 2023 Aug 21. PubMed PMID: 37603740; PubMed Central PMCID: PMC10629583.

select

Il Ahn J, Zhang L, Ravishankar H, Fan L, Kirsch K, Zeng Y, Meng L, Park JE, Yun HY, Ghirlando R, Ma B, Ball D, Ku B, Nussinov R, Schmit JD, Heinz WF, Kim SJ, Karpova T, Wang YX, Lee KS. Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells. Commun Biol. 2023 Jul 11;6(1):712. doi: 10.1038/s42003-023-05067-8. PubMed PMID: 37433832; PubMed Central PMCID: PMC10336005.

select

Park JE, Lee H, Oliva P, Kirsch K, Kim B, Ahn JI, Alverez CN, Gaikwad S, Krausz KW, O'Connor R, Rai G, Simeonov A, Mock BA, Gonzalez FJ, Lee KS, Jacobson KA. Structural Optimization and Anticancer Activity of Polo-like Kinase 1 (Plk1) Polo-Box Domain (PBD) Inhibitors and Their Prodrugs. ACS Pharmacol Transl Sci. 2023 Mar 10;6(3):422-446. doi: 10.1021/acsptsci.2c00250. eCollection 2023 Mar 10. PubMed PMID: 36926457; PubMed Central PMCID: PMC10012257.

select

Ryu S, Park JE, Ham YJ, Lim DC, Kwiatkowski NP, Kim DH, Bhunia D, Kim ND, Yaffe MB, Son W, Kim N, Choi TI, Swain P, Kim CH, Lee JY, Gray NS, Lee KS, Sim T. Novel Macrocyclic Peptidomimetics Targeting the Polo-Box Domain of Polo-Like Kinase 1. J Med Chem. 2022 Feb 10;65(3):1915-1932. doi: 10.1021/acs.jmedchem.1c01359. Epub 2022 Jan 14. PubMed PMID: 35029981; PubMed Central PMCID: PMC10411393.

select

Sonn SK, Seo S, Yang J, Oh KS, Chen H, Chan DC, Rhee K, Lee KS, Yang Y, Oh GT. ER-associated CTRP1 regulates mitochondrial fission via interaction with DRP1. Exp Mol Med. 2021 Nov;53(11):1769-1780. doi: 10.1038/s12276-021-00701-z. Epub 2021 Nov 26. PubMed PMID: 34837016; PubMed Central PMCID: PMC8639813.

select

Lee KS, Steinmetz MO. Centrosomes in the spotlight: from organization to function to role in disease. Curr Opin Struct Biol. 2021 Feb;66:iii-v. doi: 10.1016/j.sbi.2021.01.001. Epub 2021 Jan 20. PubMed PMID: 33485756.

select

Lee KS, Park JE, Ahn JI, Zeng Y. Constructing PCM with architecturally distinct higher-order assemblies. Curr Opin Struct Biol. 2021 Feb;66:66-73. doi: 10.1016/j.sbi.2020.09.013. Epub 2020 Nov 8. Review. PubMed PMID: 33176265.

select

Park JE, Meng L, Ryu EK, Nagashima K, Baxa U, Bang JK, Lee KS. Autophosphorylation-induced self-assembly and STIL-dependent reinforcement underlie Plk4's ring-to-dot localization conversion around a human centriole. Cell Cycle. 2020 Dec;19(24):3419-3436. doi: 10.1080/15384101.2020.1843772. Epub 2020 Dec 15. PubMed PMID: 33323015; PubMed Central PMCID: PMC7781628.

select

Gunasekaran P, Yim MS, Ahn M, Soung NK, Park JE, Kim J, Bang G, Shin SC, Choi J, Kim M, Kim HN, Lee YH, Chung YH, Lee K, EunKyeong Kim E, Jeon YH, Kim MJ, Lee KR, Kim BY, Lee KS, Ryu EK, Bang JK. Development of a Polo-like Kinase-1 Polo-Box Domain Inhibitor as a Tumor Growth Suppressor in Mice Models. J Med Chem. 2020 Dec 10;63(23):14905-14920. doi: 10.1021/acs.jmedchem.0c01451. Epub 2020 Nov 3. PubMed PMID: 33142063; PubMed Central PMCID: PMC8919061.

select

Ahn JI, Park JE, Meng L, Zhang L, Kim TS, Kruhlak MJ, Kim BY, Lee KS. Phase separation of the Cep63•Cep152 complex underlies the formation of dynamic supramolecular self-assemblies at human centrosomes. Cell Cycle. 2020 Dec;19(24):3437-3457. doi: 10.1080/15384101.2020.1843777. Epub 2020 Nov 18. PubMed PMID: 33208041; PubMed Central PMCID: PMC7781590.

select

Alverez CN, Park JE, Toti KS, Xia Y, Krausz KW, Rai G, Bang JK, Gonzalez FJ, Jacobson KA, Lee KS. Identification of a New Heterocyclic Scaffold for Inhibitors of the Polo-Box Domain of Polo-like Kinase 1. J Med Chem. 2020 Nov 25;63(22):14087-14117. doi: 10.1021/acs.jmedchem.0c01669. Epub 2020 Nov 11. PubMed PMID: 33175530; PubMed Central PMCID: PMC7769008.

select

Lee KS, Park JE, Il Ahn J, Wei Z, Zhang L. A self-assembled cylindrical platform for Plk4-induced centriole biogenesis. Open Biol. 2020 Aug;10(8):200102. doi: 10.1098/rsob.200102. Epub 2020 Aug 19. Review. PubMed PMID: 32810424; PubMed Central PMCID: PMC7479937.

select

Wei Z, Kim TS, Ahn JI, Meng L, Chen Y, Ryu EK, Ku B, Zhou M, Kim SJ, Bang JK, van Deursen JM, Park JE, Lee KS. Requirement of the Cep57-Cep63 Interaction for Proper Cep152 Recruitment and Centriole Duplication. Mol Cell Biol. 2020 Apr 28;40(10). doi: 10.1128/MCB.00535-19. Print 2020 Apr 28. PubMed PMID: 32152252; PubMed Central PMCID: PMC7189096.

select

Park JE, Zhang L, Bang JK, Andresson T, DiMaio F, Lee KS. Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis. Nat Commun. 2019 Oct 31;10(1):4959. doi: 10.1038/s41467-019-12619-2. PubMed PMID: 31672968; PubMed Central PMCID: PMC6823436.

select

Kim TS, Zhang L, Il Ahn J, Meng L, Chen Y, Lee E, Bang JK, Lim JM, Ghirlando R, Fan L, Wang YX, Kim BY, Park JE, Lee KS. Molecular architecture of a cylindrical self-assembly at human centrosomes. Nat Commun. 2019 Mar 11;10(1):1151. doi: 10.1038/s41467-019-08838-2. PubMed PMID: 30858376; PubMed Central PMCID: PMC6411776.

select

Soung NK, Kim HM, Asami Y, Kim DH, Cho Y, Naik R, Jang Y, Jang K, Han HJ, Ganipisetti SR, Cha-Molstad H, Hwang J, Lee KH, Ko SK, Jang JH, Ryoo IJ, Kwon YT, Lee KS, Osada H, Lee K, Kim BY, Ahn JS. Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition. Exp Mol Med. 2019 Feb 12;51(2):1-14. doi: 10.1038/s12276-018-0200-4. PubMed PMID: 30755586; PubMed Central PMCID: PMC6372683.

select

Lee KH, Hwang JA, Kim SO, Kim JH, Shin SC, Kim EE, Lee KS, Rhee K, Jeon BH, Bang JK, Cha-Molstad H, Soung NK, Jang JH, Ko SK, Lee HG, Ahn JS, Kwon YT, Kim BY. Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions. J Biol Chem. 2018 Jan 19;293(3):847-862. doi: 10.1074/jbc.M117.802587. Epub 2017 Nov 30. PubMed PMID: 29191835; PubMed Central PMCID: PMC5777258.

select

Park JE, Hymel D, Burke TR Jr, Lee KS. Current progress and future perspectives in the development of anti-polo-like kinase 1 therapeutic agents. F1000Res. 2017;6:1024. doi: 10.12688/f1000research.11398.1. eCollection 2017. Review. PubMed PMID: 28721210; PubMed Central PMCID: PMC5497816.

select

Nasa I, Trinkle-Mulcahy L, Douglas P, Chaudhuri S, Lees-Miller SP, Lee KS, Moorhead GB. Recruitment of PP1 to the centrosomal scaffold protein CEP192. Biochem Biophys Res Commun. 2017 Mar 18;484(4):864-870. doi: 10.1016/j.bbrc.2017.02.004. Epub 2017 Feb 8. PubMed PMID: 28188792; PubMed Central PMCID: PMC7888556.

select

Sakchaisri K, Kim SO, Hwang J, Soung NK, Lee KH, Choi TW, Lee Y, Park CM, Thimmegowda NR, Lee PY, Shwetha B, Srinivasrao G, Pham TT, Jang JH, Yum HW, Surh YJ, Lee KS, Park H, Kim SJ, Kwon YT, Ahn JS, Kim BY. Anticancer activity of a novel small molecule tubulin inhibitor STK899704. PLoS One. 2017;12(3):e0173311. doi: 10.1371/journal.pone.0173311. eCollection 2017. PubMed PMID: 28296906; PubMed Central PMCID: PMC5351965.

select

Lee KS, Burke TR Jr, Park JE, Bang JK, Lee E. Recent Advances and New Strategies in Targeting Plk1 for Anticancer Therapy. Trends Pharmacol Sci. 2015 Dec;36(12):858-877. doi: 10.1016/j.tips.2015.08.013. Epub 2015 Oct 17. Review. PubMed PMID: 26478211; PubMed Central PMCID: PMC4684765.

select

Qian WJ, Park JE, Grant R, Lai CC, Kelley JA, Yaffe MB, Lee KS, Burke TR Jr. Neighbor-directed histidine N (τ)-alkylation: A route to imidazolium-containing phosphopeptide macrocycles. Biopolymers. 2015 Nov;104(6):663-73. doi: 10.1002/bip.22698. PubMed PMID: 26152807; PubMed Central PMCID: PMC4865893.

select

Park JE, Kim TS, Meng L, Bang JK, Kim BY, Lee KS. Putting a bit into the polo-box domain of polo-like kinase 1. J Anal Sci Technol. 2015;6(1):27. doi: 10.1186/s40543-015-0069-y. Epub 2015 Oct 14. Review. PubMed PMID: 26500787; PubMed Central PMCID: PMC4610673.

select

Meng L, Park JE, Kim TS, Lee EH, Park SY, Zhou M, Bang JK, Lee KS. Bimodal Interaction of Mammalian Polo-Like Kinase 1 and a Centrosomal Scaffold, Cep192, in the Regulation of Bipolar Spindle Formation. Mol Cell Biol. 2015 Aug;35(15):2626-40. doi: 10.1128/MCB.00068-15. PubMed PMID: 26012549; PubMed Central PMCID: PMC4524112.

select

Lim JM, Lee KS, Woo HA, Kang D, Rhee SG. Control of the pericentrosomal H2O2 level by peroxiredoxin I is critical for mitotic progression. J Cell Biol. 2015 Jul 6;210(1):23-33. doi: 10.1083/jcb.201412068. PubMed PMID: 26150388; PubMed Central PMCID: PMC4493999.

select

Kim JH, Ku B, Lee KS, Kim SJ. Structural analysis of the polo-box domain of human Polo-like kinase 2. Proteins. 2015 Jul;83(7):1201-8. doi: 10.1002/prot.24804. Epub 2015 Apr 28. PubMed PMID: 25846005; PubMed Central PMCID: PMC7720676.

select

Park CH, Park JE, Kim TS, Kang YH, Soung NK, Zhou M, Kim NH, Bang JK, Lee KS. Mammalian Polo-like kinase 1 (Plk1) promotes proper chromosome segregation by phosphorylating and delocalizing the PBIP1·CENP-Q complex from kinetochores. J Biol Chem. 2015 Mar 27;290(13):8569-81. doi: 10.1074/jbc.M114.623546. Epub 2015 Feb 10. PubMed PMID: 25670858; PubMed Central PMCID: PMC4375506.

select

Park JE, Kim TS, Kim BY, Lee KS. Selective blockade of cancer cell proliferation and anchorage-independent growth by Plk1 activity-dependent suicidal inhibition of its polo-box domain. Cell Cycle. 2015;14(22):3624-34. doi: 10.1080/15384101.2015.1104435. PubMed PMID: 26513691; PubMed Central PMCID: PMC4825759.

select

Qian WJ, Park JE, Lim D, Lai CC, Kelley JA, Park SY, Lee KW, Yaffe MB, Lee KS, Burke TR Jr. Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high Plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in HeLa cells. Biopolymers. 2014 Nov;102(6):444-55. doi: 10.1002/bip.22569. PubMed PMID: 25283071; PubMed Central PMCID: PMC4895914.

select

Srinivasrao G, Park JE, Kim S, Ahn M, Cheong C, Nam KY, Gunasekaran P, Hwang E, Kim NH, Shin SY, Lee KS, Ryu E, Bang JK. Design and synthesis of a cell-permeable, drug-like small molecule inhibitor targeting the polo-box domain of polo-like kinase 1. PLoS One. 2014;9(9):e107432. doi: 10.1371/journal.pone.0107432. eCollection 2014. PubMed PMID: 25211362; PubMed Central PMCID: PMC4161390.

select

Park SY, Park JE, Kim TS, Kim JH, Kwak MJ, Ku B, Tian L, Murugan RN, Ahn M, Komiya S, Hojo H, Kim NH, Kim BY, Bang JK, Erikson RL, Lee KW, Kim SJ, Oh BH, Yang W, Lee KS. Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis. Nat Struct Mol Biol. 2014 Aug;21(8):696-703. doi: 10.1038/nsmb.2846. Epub 2014 Jun 29. PubMed PMID: 24997597; PubMed Central PMCID: PMC4125498.

select

Lee KS, Park JE, Kang YH, Kim TS, Bang JK. Mechanisms underlying Plk1 polo-box domain-mediated biological processes and their physiological significance. Mol Cells. 2014 Apr;37(4):286-94. doi: 10.14348/molcells.2014.0002. Epub 2014 Apr 7. Review. PubMed PMID: 24722413; PubMed Central PMCID: PMC4012076.

select

Lee M, Chang J, Chang S, Lee KS, Rhee K. Asymmetric spindle pole formation in CPAP-depleted mitotic cells. Biochem Biophys Res Commun. 2014 Feb 21;444(4):644-50. doi: 10.1016/j.bbrc.2014.01.129. Epub 2014 Feb 1. PubMed PMID: 24491538; PubMed Central PMCID: PMC7667489.

select

Kim TS, Park JE, Shukla A, Choi S, Murugan RN, Lee JH, Ahn M, Rhee K, Bang JK, Kim BY, Loncarek J, Erikson RL, Lee KS. Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4849-57. doi: 10.1073/pnas.1319656110. Epub 2013 Nov 25. PubMed PMID: 24277814; PubMed Central PMCID: PMC3864335.

select

Ahn M, Murugan RN, Jacob B, Hyun JK, Cheong C, Hwang E, Park HN, Seo JH, Srinivasrao G, Lee KS, Shin SY, Bang JK. Discovery of novel histidine-derived lipo-amino acids: applied in the synthesis of ultra-short antimicrobial peptidomimetics having potent antimicrobial activity, salt resistance and protease stability. Eur J Med Chem. 2013 Oct;68:10-8. doi: 10.1016/j.ejmech.2013.07.008. Epub 2013 Jul 26. PubMed PMID: 23933046.

select

Murugan RN, Jacob B, Kim EH, Ahn M, Sohn H, Seo JH, Cheong C, Hyun JK, Lee KS, Shin SY, Bang JK. Non hemolytic short peptidomimetics as a new class of potent and broad-spectrum antimicrobial agents. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4633-6. doi: 10.1016/j.bmcl.2013.06.016. Epub 2013 Jun 14. PubMed PMID: 23816372.

select

Zou J, Rezvani K, Wang H, Lee KS, Zhang D. BRCA1 downregulates the kinase activity of Polo-like kinase 1 in response to replication stress. Cell Cycle. 2013 Jul 15;12(14):2255-65. doi: 10.4161/cc.25349. PubMed PMID: 24067368; PubMed Central PMCID: PMC3755076.

select

Qian W, Park JE, Liu F, Lee KS, Burke TR Jr. Effects on polo-like kinase 1 polo-box domain binding affinities of peptides incurred by structural variation at the phosphoamino acid position. Bioorg Med Chem. 2013 Jul 15;21(14):3996-4003. doi: 10.1016/j.bmc.2012.05.036. Epub 2012 May 26. PubMed PMID: 22743087; PubMed Central PMCID: PMC3462889.

select

Murugan RN, Park JE, Lim D, Ahn M, Cheong C, Kwon T, Nam KY, Choi SH, Kim BY, Yoon DY, Yaffe MB, Yu DY, Lee KS, Bang JK. Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1. Bioorg Med Chem. 2013 May 1;21(9):2623-34. doi: 10.1016/j.bmc.2013.02.020. Epub 2013 Feb 27. PubMed PMID: 23498919; PubMed Central PMCID: PMC7561269.

select

González-Sancho JM, Greer YE, Abrahams CL, Takigawa Y, Baljinnyam B, Lee KH, Lee KS, Rubin JS, Brown AM. Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling. J Biol Chem. 2013 Mar 29;288(13):9428-37. doi: 10.1074/jbc.M112.448480. Epub 2013 Feb 8. PubMed PMID: 23396967; PubMed Central PMCID: PMC3611012.

select

Chang J, Seo SG, Lee KH, Nagashima K, Bang JK, Kim BY, Erikson RL, Lee KW, Lee HJ, Park JE, Lee KS. Essential role of Cenexin1, but not Odf2, in ciliogenesis. Cell Cycle. 2013 Feb 15;12(4):655-62. doi: 10.4161/cc.23585. Epub 2013 Jan 23. PubMed PMID: 23343771; PubMed Central PMCID: PMC3594266.

select

He L, Lee J, Jang JH, Sakchaisri K, Hwang J, Cha-Molstad HJ, Kim KA, Ryoo IJ, Lee HG, Kim SO, Soung NK, Lee KS, Kwon YT, Erikson RL, Ahn JS, Kim BY. Osteoporosis regulation by salubrinal through eIF2α mediated differentiation of osteoclast and osteoblast. Cell Signal. 2013 Feb;25(2):552-60. doi: 10.1016/j.cellsig.2012.11.015. Epub 2012 Nov 23. PubMed PMID: 23178987; PubMed Central PMCID: PMC3593652.

select

He L, Jang JH, Choi HG, Lee SM, Nan MH, Jeong SJ, Dong Z, Kwon YT, Lee KS, Lee KW, Chung JK, Ahn JS, Kim BY. Oligomycin A enhances apoptotic effect of TRAIL through CHOP-mediated death receptor 5 expression. Mol Carcinog. 2013 Feb;52(2):85-93. doi: 10.1002/mc.21831. Epub 2011 Nov 15. PubMed PMID: 23335397.

select

Kim SO, Sakchaisri K, Thimmegowda NR, Soung NK, Jang JH, Kim YS, Lee KS, Kwon YT, Asami Y, Ahn JS, Erikson RL, Kim BY. STK295900, a dual inhibitor of topoisomerase 1 and 2, induces G(2) arrest in the absence of DNA damage. PLoS One. 2013;8(1):e53908. doi: 10.1371/journal.pone.0053908. Epub 2013 Jan 22. PubMed PMID: 23349762; PubMed Central PMCID: PMC3551932.

select

Huong PT, Soung NK, Jang JH, Cha-Molstad HJ, Sakchaisri K, Kim SO, Jang JM, Kim KE, Lee KS, Kwon YT, Erikson RL, Ahn JS, Kim BY. Regulation of CEP131 gene expression by SP1. Gene. 2013 Jan 15;513(1):75-81. doi: 10.1016/j.gene.2012.10.074. Epub 2012 Nov 5. PubMed PMID: 23137637.

select

Qian WJ, Park JE, Lee KS, Burke TR Jr. Non-proteinogenic amino acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo box domain (PBD) of polo-like kinase 1 (Plk1). Bioorg Med Chem Lett. 2012 Dec 15;22(24):7306-8. doi: 10.1016/j.bmcl.2012.10.093. Epub 2012 Oct 27. PubMed PMID: 23159568; PubMed Central PMCID: PMC3530200.

select

Liu F, Park JE, Qian WJ, Lim D, Scharow A, Berg T, Yaffe MB, Lee KS, Burke TR Jr. Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1. Chembiochem. 2012 Jun 18;13(9):1291-6. doi: 10.1002/cbic.201200206. Epub 2012 May 8. PubMed PMID: 22570300; PubMed Central PMCID: PMC4536914.

select

Lee KH, Johmura Y, Yu LR, Park JE, Gao Y, Bang JK, Zhou M, Veenstra TD, Yeon Kim B, Lee KS. Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway. EMBO J. 2012 May 18;31(14):3104-17. doi: 10.1038/emboj.2012.144. PubMed PMID: 22609948; PubMed Central PMCID: PMC3400010.

select

Liu F, Park JE, Qian WJ, Lim D, Scharow A, Berg T, Yaffe MB, Lee KS, Burke TR Jr. Identification of high affinity polo-like kinase 1 (Plk1) polo-box domain binding peptides using oxime-based diversification. ACS Chem Biol. 2012 May 18;7(5):805-10. doi: 10.1021/cb200469a. Epub 2012 Feb 14. PubMed PMID: 22292814; PubMed Central PMCID: PMC3355227.