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Zisi Tegou F, Velluto D, Stock AA, Fitzgerald SN, Stealey S, Zustiak SP, Bayer AL, Tomei AA. CCL21 and beta-cell antigen releasing hydrogels as tolerance-inducing therapy in Type I diabetes. J Control Release. 2022 Aug;348:499-517. doi: 10.1016/j.jconrel.2022.06.008. Epub 2022 Jun 16. PubMed PMID: 35691500.
Stock AA, Gonzalez GC, Pete SI, De Toni T, Berman DM, Rabassa A, Diaz W, Geary JC Jr, Willman M, Jackson JM, DeHaseth NH, Ziebarth NM, Hogan AR, Ricordi C, Kenyon NS, Tomei AA. Performance of islets of Langerhans conformally coated via an emulsion cross-linking method in diabetic rodents and nonhuman primates. Sci Adv. 2022 Jul;8(26):eabm3145. doi: 10.1126/sciadv.abm3145. Epub 2022 Jun 29. PubMed PMID: 35767620; PubMed Central PMCID: PMC9242596.
De Toni T, Stock AA, Devaux F, Gonzalez GC, Nunez K, Rubanich JC, Safley SA, Weber CJ, Ziebarth NM, Buchwald P, Tomei AA. Parallel Evaluation of Polyethylene Glycol Conformal Coating and Alginate Microencapsulation as Immunoisolation Strategies for Pancreatic Islet Transplantation. Front Bioeng Biotechnol. 2022;10:886483. doi: 10.3389/fbioe.2022.886483. eCollection 2022. PubMed PMID: 35651551; PubMed Central PMCID: PMC9149081.
Velluto D, Bojadzic D, De Toni T, Buchwald P, Tomei AA. Drug-Integrating Amphiphilic Nanomaterial Assemblies: 1. Spatiotemporal control of cyclosporine delivery and activity using nanomicelles and nanofibrils. J Control Release. 2021 Jan 10;329:955-970. doi: 10.1016/j.jconrel.2020.10.026. Epub 2020 Oct 18. PubMed PMID: 33086102; PubMed Central PMCID: PMC7904645.
Gonzalez Badillo F, Zisi Tegou F, Masina R, Wright S, Scully M, Harwell L, Lupp M, Postigo-Fernandez J, Creusot RJ, Tomei AA. Tissue-Engineered Stromal Reticula to Study Lymph Node Fibroblastic Reticular Cells in Type I Diabetes. Cell Mol Bioeng. 2020 Oct;13(5):419-434. doi: 10.1007/s12195-020-00627-y. eCollection 2020 Oct. PubMed PMID: 33184575; PubMed Central PMCID: PMC7596159.
Tamburrini R, Chaimov D, Asthana A, Gazia C, Enck K, Muir SM, Aziz JM, Lablanche S, Tubbs E, Tomei AA, Van Dyke M, Soker S, Opara EC, Orlando G. Detergent-Free Decellularization of the Human Pancreas for Soluble Extracellular Matrix (ECM) Production. J Vis Exp. 2020 Sep 4;(163). doi: 10.3791/61663. PubMed PMID: 32955501.
Safley SA, Kenyon NS, Berman DM, Barber GF, Cui H, Duncanson S, De Toni T, Willman M, De Vos P, Tomei AA, Sambanis A, Kenyon NM, Ricordi C, Weber CJ. Microencapsulated islet allografts in diabetic NOD mice and nonhuman primates. Eur Rev Med Pharmacol Sci. 2020 Aug;24(16):8551-8565. doi: 10.26355/eurrev_202008_22651. PubMed PMID: 32894560.
Sibilla S, Manenti S, Cazzato T, Colombo F, Tomei AA, Redaelli A, Manzoli V, Consolo F. Smoothed Particle Hydrodynamics multiphase modelling of an experimental microfluidic device for conformal coating of pancreatic islets. Med Eng Phys. 2020 Mar;77:19-30. doi: 10.1016/j.medengphy.2020.01.004. Epub 2020 Jan 31. PubMed PMID: 32008936; PubMed Central PMCID: PMC7568447.
Stock AA, Manzoli V, De Toni T, Abreu MM, Poh YC, Ye L, Roose A, Pagliuca FW, Thanos C, Ricordi C, Tomei AA. Conformal Coating of Stem Cell-Derived Islets for β Cell Replacement in Type 1 Diabetes. Stem Cell Reports. 2020 Jan 14;14(1):91-104. doi: 10.1016/j.stemcr.2019.11.004. Epub 2019 Dec 12. PubMed PMID: 31839542; PubMed Central PMCID: PMC6962554.
Alcazar O, Buchwald P. Concentration-Dependency and Time Profile of Insulin Secretion: Dynamic Perifusion Studies With Human and Murine Islets. Front Endocrinol (Lausanne). 2019;10:680. doi: 10.3389/fendo.2019.00680. eCollection 2019. PubMed PMID: 31632354; PubMed Central PMCID: PMC6783504.
Gonzalez Badillo FE, Zisi Tegou F, Abreu MM, Masina R, Sha D, Najjar M, Wright SH, Bayer AL, Korpos É, Pugliese A, Molano RD, Tomei AA. CCL21 Expression in β-Cells Induces Antigen-Expressing Stromal Cell Networks in the Pancreas and Prevents Autoimmune Diabetes in Mice. Diabetes. 2019 Oct;68(10):1990-2003. doi: 10.2337/db19-0239. Epub 2019 Aug 1. PubMed PMID: 31371518; PubMed Central PMCID: PMC6754241.
Verheyen CA, Morales L, Sussman J, Paunovska K, Manzoli V, Ziebarth NM, Tomei AA. Characterization of Polyethylene Glycol-Reinforced Alginate Microcapsules for Mechanically Stable Cell Immunoisolation. Macromol Mater Eng. 2019 Apr;304(4). doi: 10.1002/mame.201800679. Epub 2019 Feb 8. PubMed PMID: 31929732; PubMed Central PMCID: PMC6953757.
Tomei AA. Engineering Confined and Prevascularized Sites for Islet Transplantation. Transplantation. 2018 Nov;102(11):1793-1794. doi: 10.1097/TP.0000000000002290. PubMed PMID: 29794938; PubMed Central PMCID: PMC6197891.
Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A, Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U, Vallier L, Grey ST, Tang Q, Roep B, Ricordi C, Naji A, Orlando G, Anderson DG, Poznansky M, Ludwig B, Tomei A, Greiner DL, Graham M, Carpenter M, Migliaccio G, D'Amour K, Hering B, Piemonti L, Berney T, Rickels M, Kay T, Adams A. Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells. Transplantation. 2018 Aug;102(8):1223-1229. doi: 10.1097/TP.0000000000002217. Review. PubMed PMID: 29781950; PubMed Central PMCID: PMC6775764.
Manzoli V, Villa C, Bayer AL, Morales LC, Molano RD, Torrente Y, Ricordi C, Hubbell JA, Tomei AA. Immunoisolation of murine islet allografts in vascularized sites through conformal coating with polyethylene glycol. Am J Transplant. 2018 Mar;18(3):590-603. doi: 10.1111/ajt.14547. Epub 2017 Dec 2. PubMed PMID: 29068143; PubMed Central PMCID: PMC5820142.
Ciccocioppo R, Dos Santos CC, Baumgart DC, Cangemi GC, Cardinale V, Ciacci C, De Coppi P, Haldar D, Klersy C, Nostro MC, Ott M, Piemonti L, Tomei AA, Uygun B, Vetrano S, Orlando G. Proceedings of the signature series event of the international society for cellular therapy: "Advancements in cellular therapies and regenerative medicine in digestive diseases," London, United Kingdom, May 3, 2017. Cytotherapy. 2018 Mar;20(3):461-476. doi: 10.1016/j.jcyt.2017.12.004. Epub 2018 Feb 15. PubMed PMID: 29398624; PubMed Central PMCID: PMC6771025.
Buchwald P, Tamayo-Garcia A, Manzoli V, Tomei AA, Stabler CL. Glucose-stimulated insulin release: Parallel perifusion studies of free and hydrogel encapsulated human pancreatic islets. Biotechnol Bioeng. 2018 Jan;115(1):232-245. doi: 10.1002/bit.26442. Epub 2017 Sep 19. PubMed PMID: 28865118; PubMed Central PMCID: PMC5699962.
Manzoli V, Colter DC, Dhanaraj S, Fornoni A, Ricordi C, Pileggi A, Tomei AA. Engineering human renal epithelial cells for transplantation in regenerative medicine. Med Eng Phys. 2017 Oct;48:3-13. doi: 10.1016/j.medengphy.2017.03.009. Epub 2017 Apr 14. PubMed PMID: 28416198.
Villa C, Manzoli V, Abreu MM, Verheyen CA, Seskin M, Najjar M, Molano RD, Torrente Y, Ricordi C, Tomei AA. Effects of Composition of Alginate-Polyethylene Glycol Microcapsules and Transplant Site on Encapsulated Islet Graft Outcomes in Mice. Transplantation. 2017 May;101(5):1025-1035. doi: 10.1097/TP.0000000000001454. PubMed PMID: 27525644; PubMed Central PMCID: PMC5642344.
Najjar M, Manzoli V, Abreu M, Villa C, Martino MM, Molano RD, Torrente Y, Pileggi A, Inverardi L, Ricordi C, Hubbell JA, Tomei AA. Fibrin gels engineered with pro-angiogenic growth factors promote engraftment of pancreatic islets in extrahepatic sites in mice. Biotechnol Bioeng. 2015 Sep;112(9):1916-26. doi: 10.1002/bit.25589. Epub 2015 Jul 7. PubMed PMID: 25786390.
Tomei AA, Villa C, Ricordi C. Development of an encapsulated stem cell-based therapy for diabetes. Expert Opin Biol Ther. 2015;15(9):1321-36. doi: 10.1517/14712598.2015.1055242. Epub 2015 Jul 9. Review. PubMed PMID: 26156291; PubMed Central PMCID: PMC6329003.
Tomei AA, Manzoli V, Fraker CA, Giraldo J, Velluto D, Najjar M, Pileggi A, Molano RD, Ricordi C, Stabler CL, Hubbell JA. Device design and materials optimization of conformal coating for islets of Langerhans. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10514-9. doi: 10.1073/pnas.1402216111. Epub 2014 Jun 30. PubMed PMID: 24982192; PubMed Central PMCID: PMC4115512.
Dane KY, Nembrini C, Tomei AA, Eby JK, O'Neil CP, Velluto D, Swartz MA, Inverardi L, Hubbell JA. Nano-sized drug-loaded micelles deliver payload to lymph node immune cells and prolong allograft survival. J Control Release. 2011 Dec 10;156(2):154-60. doi: 10.1016/j.jconrel.2011.08.009. Epub 2011 Aug 12. PubMed PMID: 21864593.
Shields JD, Kourtis IC, Tomei AA, Roberts JM, Swartz MA. Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21. Science. 2010 May 7;328(5979):749-52. doi: 10.1126/science.1185837. Epub 2010 Mar 25. PubMed PMID: 20339029.
Tomei AA, Siegert S, Britschgi MR, Luther SA, Swartz MA. Fluid flow regulates stromal cell organization and CCL21 expression in a tissue-engineered lymph node microenvironment. J Immunol. 2009 Oct 1;183(7):4273-83. doi: 10.4049/jimmunol.0900835. Epub 2009 Sep 4. PubMed PMID: 19734211.
Tomei AA, Boschetti F, Gervaso F, Swartz MA. 3D collagen cultures under well-defined dynamic strain: a novel strain device with a porous elastomeric support. Biotechnol Bioeng. 2009 May 1;103(1):217-25. doi: 10.1002/bit.22236. PubMed PMID: 19148875.
Boschetti F, Tomei AA, Turri S, Swartz MA, Levi M. Design, fabrication, and characterization of a composite scaffold for bone tissue engineering. Int J Artif Organs. 2008 Aug;31(8):697-707. doi: 10.1177/039139880803100803. PubMed PMID: 18825642.
Tomei AA, Choe MM, Swartz MA. Effects of dynamic compression on lentiviral transduction in an in vitro airway wall model. Am J Physiol Lung Cell Mol Physiol. 2008 Jan;294(1):L79-86. doi: 10.1152/ajplung.00062.2007. Epub 2007 Nov 16. PubMed PMID: 18024723.
Shields JD, Fleury ME, Yong C, Tomei AA, Randolph GJ, Swartz MA. Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling. Cancer Cell. 2007 Jun;11(6):526-38. doi: 10.1016/j.ccr.2007.04.020. PubMed PMID: 17560334.
Choe MM, Tomei AA, Swartz MA. Physiological 3D tissue model of the airway wall and mucosa. Nat Protoc. 2006;1(1):357-62. doi: 10.1038/nprot.2006.54. PubMed PMID: 17406256.
Tissue-Engineered Stromal Reticula to Study Lymph Node Fibroblastic Reticular Cells in Type I Diabetes. Cellular and molecular bioengineering. . NIHMSID: NIHMS1607470.
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