My Bibliography

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Shi G, Hu Y. TNFR1 and TNFR2, Which Link NF-κB Activation, Drive Lung Cancer Progression, Cell Dedifferentiation, and Metastasis. Cancers (Basel). 2023 Aug 28;15(17). doi: 10.3390/cancers15174299. Review. PubMed PMID: 37686574; PubMed Central PMCID: PMC10487001.

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Xiao Z, Shi G, Xi S, Singh AK, Willette-Brown J, Li X, Zhu F, Su L, Wu X, Schrump DS, Hu Y. A TNFR1-UBCH10 axis drives lung squamous cell carcinoma dedifferentiation and metastasis through a cell-autonomous signaling loop. Cell Death Dis. 2022 Oct 21;13(10):885. doi: 10.1038/s41419-022-05308-4. PubMed PMID: 36270982; PubMed Central PMCID: PMC9587052.

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Song NY, Li X, Ma B, Willette-Brown J, Zhu F, Jiang C, Su L, Shetty J, Zhao Y, Shi G, Banerjee S, Wu X, Tran B, Nussinov R, Karin M, Hu Y. IKKα-deficient lung adenocarcinomas generate an immunosuppressive microenvironment by overproducing Treg-inducing cytokines. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6). doi: 10.1073/pnas.2120956119. PubMed PMID: 35121655; PubMed Central PMCID: PMC8833198.

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McCorkell KA, Jayachandran N, Cully MD, Freund-Brown J, Weinkopff T, Monslow J, Hu Y, Puré E, Freedman BD, Alvarez JI, Cancro MP, May MJ. Lymph node formation and B cell homeostasis require IKK-α in distinct endothelial cell-derived compartments. Proc Natl Acad Sci U S A. 2021 Nov 30;118(48). doi: 10.1073/pnas.2100195118. PubMed PMID: 34810256; PubMed Central PMCID: PMC8640927.

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Zhu F, Willette-Brown J, Zhang J, Ferre EMN, Sun Z, Wu X, Lionakis MS, Hu Y. NLRP3 Inhibition Ameliorates Severe Cutaneous Autoimmune Manifestations in a Mouse Model of Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy-Like Disease. J Invest Dermatol. 2021 Jun;141(6):1404-1415. doi: 10.1016/j.jid.2020.10.016. Epub 2020 Nov 11. PubMed PMID: 33188780; PubMed Central PMCID: PMC8110612.

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Su H, Yang F, Fu R, Li X, French R, Mose E, Pu X, Trinh B, Kumar A, Liu J, Antonucci L, Todoric J, Liu Y, Hu Y, Diaz-Meco MT, Moscat J, Metallo CM, Lowy AM, Sun B, Karin M. Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis. Cancer Cell. 2021 May 10;39(5):678-693.e11. doi: 10.1016/j.ccell.2021.02.016. Epub 2021 Mar 18. PubMed PMID: 33740421; PubMed Central PMCID: PMC8119368.

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Park SY, Hwang BO, Lim M, Ok SH, Lee SK, Chun KS, Park KK, Hu Y, Chung WY, Song NY. Oral-Gut Microbiome Axis in Gastrointestinal Disease and Cancer. Cancers (Basel). 2021 Apr 28;13(9). doi: 10.3390/cancers13092124. Review. PubMed PMID: 33924899; PubMed Central PMCID: PMC8125773.

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Li X, Hu Y. Attribution of NF-κB Activity to CHUK/IKKα-Involved Carcinogenesis. Cancers (Basel). 2021 Mar 19;13(6). doi: 10.3390/cancers13061411. Review. PubMed PMID: 33808757; PubMed Central PMCID: PMC8003426.

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Chen S, Sun Q, Sun D, Willette-Brown J, Anderson MJ, Gu Q, Lewandoski M, Hu Y, Zhu F, Wei F, Zhang J. C-CBL is required for inhibition of angiogenesis through modulating JAK2/STAT3 activity in ROP development. Biomed Pharmacother. 2020 Dec;132:110856. doi: 10.1016/j.biopha.2020.110856. Epub 2020 Oct 28. PubMed PMID: 33125970; PubMed Central PMCID: PMC8336301.

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Yamada A, Kawasaki M, Miake Y, Yamada Y, Blackburn J, Kawasaki K, Trakanant S, Nagai T, Nihara J, Kudo T, Meguro F, Schmidt-Ullrich R, Liu B, Hu Y, Page A, Ramírez Á, Sharpe PT, Maeda T, Takagi R, Ohazama A. Overactivation of the NF-κB pathway impairs molar enamel formation. Oral Dis. 2020 Oct;26(7):1513-1522. doi: 10.1111/odi.13384. Epub 2020 Jul 9. PubMed PMID: 32369672; PubMed Central PMCID: PMC8921976.

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Balkhi MY, Willette-Brown J, Wittmann G, Hu Y. IKKα deficiency disrupts the development of marginal zone and follicular B cells. Genes Immun. 2019 Mar;20(3):224-233. doi: 10.1038/s41435-018-0025-0. Epub 2018 May 8. PubMed PMID: 29740197; PubMed Central PMCID: PMC8191388.

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Ramakrishnan SK, Zhang H, Ma X, Jung I, Schwartz AJ, Triner D, Devenport SN, Das NK, Xue X, Zeng MY, Hu Y, Mortensen RM, Greenson JK, Cascalho M, Wobus CE, Colacino JA, Nunez G, Rui L, Shah YM. Intestinal non-canonical NFκB signaling shapes the local and systemic immune response. Nat Commun. 2019 Feb 8;10(1):660. doi: 10.1038/s41467-019-08581-8. PubMed PMID: 30737385; PubMed Central PMCID: PMC6368617.

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Ruder B, Murtadak V, Stürzl M, Wirtz S, Distler U, Tenzer S, Mahapatro M, Greten FR, Hu Y, Neurath MF, Cesarman E, Ballon G, Günther C, Becker C. Chronic intestinal inflammation in mice expressing viral Flip in epithelial cells. Mucosal Immunol. 2018 Nov;11(6):1621-1629. doi: 10.1038/s41385-018-0068-6. Epub 2018 Aug 13. PubMed PMID: 30104627; PubMed Central PMCID: PMC8063487.

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Gray Z, Shi G, Wang X, Hu Y. Macrophage inducible nitric oxide synthase promotes the initiation of lung squamous cell carcinoma by maintaining circulated inflammation. Cell Death Dis. 2018 May 29;9(6):642. doi: 10.1038/s41419-018-0653-3. PubMed PMID: 29844374; PubMed Central PMCID: PMC5973934.

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Zhu F, Hu Y. Integrity of IKK/NF-κB Shields Thymic Stroma That Suppresses Susceptibility to Autoimmunity, Fungal Infection, and Carcinogenesis. Bioessays. 2018 Apr;40(4):e1700131. doi: 10.1002/bies.201700131. Epub 2018 Mar 9. Review. PubMed PMID: 29522649.

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Wang X, Gray Z, Willette-Brown J, Zhu F, Shi G, Jiang Q, Song NY, Dong L, Hu Y. Macrophage inducible nitric oxide synthase circulates inflammation and promotes lung carcinogenesis. Cell Death Discov. 2018;4:46. doi: 10.1038/s41420-018-0046-5. eCollection 2018. PubMed PMID: 29844930; PubMed Central PMCID: PMC5967330.

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Song NY, Zhu F, Wang Z, Willette-Brown J, Xi S, Sun Z, Su L, Wu X, Ma B, Nussinov R, Xia X, Schrump DS, Johnson PF, Karin M, Hu Y. IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E812-E821. doi: 10.1073/pnas.1717520115. Epub 2018 Jan 8. PubMed PMID: 29311298; PubMed Central PMCID: PMC5789942.

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Zhu F, Willette-Brown J, Song NY, Lomada D, Song Y, Xue L, Gray Z, Zhao Z, Davis SR, Sun Z, Zhang P, Wu X, Zhan Q, Richie ER, Hu Y. Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis. Cell Host Microbe. 2017 Apr 12;21(4):478-493.e7. doi: 10.1016/j.chom.2017.03.006. PubMed PMID: 28407484; PubMed Central PMCID: PMC5868740.

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Diamanti MA, Gupta J, Bennecke M, De Oliveira T, Ramakrishnan M, Braczynski AK, Richter B, Beli P, Hu Y, Saleh M, Mittelbronn M, Dikic I, Greten FR. IKKα controls ATG16L1 degradation to prevent ER stress during inflammation. J Exp Med. 2017 Feb;214(2):423-437. doi: 10.1084/jem.20161867. Epub 2017 Jan 12. PubMed PMID: 28082356; PubMed Central PMCID: PMC5294863.

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Marien E, Meister M, Muley T, Gomez Del Pulgar T, Derua R, Spraggins JM, Van de Plas R, Vanderhoydonc F, Machiels J, Binda MM, Dehairs J, Willette-Brown J, Hu Y, Dienemann H, Thomas M, Schnabel PA, Caprioli RM, Lacal JC, Waelkens E, Swinnen JV. Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma. Oncotarget. 2016 Mar 15;7(11):12582-97. doi: 10.18632/oncotarget.7179. PubMed PMID: 26862848; PubMed Central PMCID: PMC4914306.

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Hu Y. A feedforward loop of NLRC5 (de)ubiquitination keeps IKK-NF-κB in check. J Cell Biol. 2015 Dec 7;211(5):941-3. doi: 10.1083/jcb.201511039. Epub 2015 Nov 30. PubMed PMID: 26620908; PubMed Central PMCID: PMC4674284.

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Giacomin PR, Moy RH, Noti M, Osborne LC, Siracusa MC, Alenghat T, Liu B, McCorkell KA, Troy AE, Rak GD, Hu Y, May MJ, Ma HL, Fouser LA, Sonnenberg GF, Artis D. Epithelial-intrinsic IKKα expression regulates group 3 innate lymphoid cell responses and antibacterial immunity. J Exp Med. 2015 Sep 21;212(10):1513-28. doi: 10.1084/jem.20141831. Epub 2015 Sep 14. PubMed PMID: 26371187; PubMed Central PMCID: PMC4577836.

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Chen X, Willette-Brown J, Wu X, Hu Y, Howard OM, Hu Y, Oppenheim JJ. IKKα is required for the homeostasis of regulatory T cells and for the expansion of both regulatory and effector CD4 T cells. FASEB J. 2015 Feb;29(2):443-54. doi: 10.1096/fj.14-259564. Epub 2014 Nov 5. PubMed PMID: 25376833; PubMed Central PMCID: PMC4314223.

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Blackburn J, Kawasaki K, Porntaveetus T, Kawasaki M, Otsuka-Tanaka Y, Miake Y, Ota MS, Watanabe M, Hishinuma M, Nomoto T, Oommen S, Ghafoor S, Harada F, Nozawa-Inoue K, Maeda T, Peterková R, Lesot H, Inoue J, Akiyama T, Schmidt-Ullrich R, Liu B, Hu Y, Page A, Ramírez Á, Sharpe PT, Ohazama A. Excess NF-κB induces ectopic odontogenesis in embryonic incisor epithelium. J Dent Res. 2015 Jan;94(1):121-8. doi: 10.1177/0022034514556707. Epub 2014 Nov 6. PubMed PMID: 25376721; PubMed Central PMCID: PMC6728577.

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Martin BN, Wang C, Willette-Brown J, Herjan T, Gulen MF, Zhou H, Bulek K, Franchi L, Sato T, Alnemri ES, Narla G, Zhong XP, Thomas J, Klinman D, Fitzgerald KA, Karin M, Nuñez G, Dubyak G, Hu Y, Li X. IKKα negatively regulates ASC-dependent inflammasome activation. Nat Commun. 2014 Sep 30;5:4977. doi: 10.1038/ncomms5977. PubMed PMID: 25266676; PubMed Central PMCID: PMC4298287.

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Göktuna SI, Canli O, Bollrath J, Fingerle AA, Horst D, Diamanti MA, Pallangyo C, Bennecke M, Nebelsiek T, Mankan AK, Lang R, Artis D, Hu Y, Patzelt T, Ruland J, Kirchner T, Taketo MM, Chariot A, Arkan MC, Greten FR. IKKα promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells. Cell Rep. 2014 Jun 26;7(6):1914-25. doi: 10.1016/j.celrep.2014.05.006. Epub 2014 May 29. PubMed PMID: 24882009; PubMed Central PMCID: PMC7676455.

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Xia X, Liu S, Xiao Z, Zhu F, Song NY, Zhou M, Liu B, Shen J, Nagashima K, Veenstra TD, Burkett S, Datla M, Willette-Brown J, Shen H, Hu Y. An IKKα-nucleophosmin axis utilizes inflammatory signaling to promote genome integrity. Cell Rep. 2013 Dec 12;5(5):1243-55. doi: 10.1016/j.celrep.2013.10.046. Epub 2013 Nov 27. PubMed PMID: 24290756; PubMed Central PMCID: PMC4159076.

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Jellusova J, Miletic AV, Cato MH, Lin WW, Hu Y, Bishop GA, Shlomchik MJ, Rickert RC. Context-specific BAFF-R signaling by the NF-κB and PI3K pathways. Cell Rep. 2013 Nov 27;5(4):1022-35. doi: 10.1016/j.celrep.2013.10.022. Epub 2013 Nov 14. PubMed PMID: 24239354; PubMed Central PMCID: PMC3887557.

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Xiao Z, Jiang Q, Willette-Brown J, Xi S, Zhu F, Burkett S, Back T, Song NY, Datla M, Sun Z, Goldszmid R, Lin F, Cohoon T, Pike K, Wu X, Schrump DS, Wong KK, Young HA, Trinchieri G, Wiltrout RH, Hu Y. The pivotal role of IKKα in the development of spontaneous lung squamous cell carcinomas. Cancer Cell. 2013 Apr 15;23(4):527-40. doi: 10.1016/j.ccr.2013.03.009. PubMed PMID: 23597566; PubMed Central PMCID: PMC3649010.

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Xia X, Park E, Fischer SM, Hu Y. Mouse Genetic Models Reveal Surprising Functions of IkB Kinase Alpha in Skin Development and Skin Carcinogenesis. Cancers (Basel). 2013 Feb 15;5(1):170-83. doi: 10.3390/cancers5010170. PubMed PMID: 24216703; PubMed Central PMCID: PMC3730312.

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Balkhi MY, Willette-Brown J, Zhu F, Chen Z, Liu S, Guttridge DC, Karin M, Hu Y. IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis. Blood. 2012 Jun 7;119(23):5467-77. doi: 10.1182/blood-2012-01-401547. Epub 2012 Apr 27. PubMed PMID: 22544702; PubMed Central PMCID: PMC3369682.

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Blackburn J, Ohazama A, Kawasaki K, Otsuka-Tanaka Y, Liu B, Honda K, Rountree RB, Hu Y, Kawasaki M, Birchmeier W, Schmidt-Ullrich R, Kinoshita A, Schutte BC, Hammond NL, Dixon MJ, Sharpe PT. The role of Irf6 in tooth epithelial invagination. Dev Biol. 2012 May 1;365(1):61-70. doi: 10.1016/j.ydbio.2012.02.009. Epub 2012 Feb 14. PubMed PMID: 22366192; PubMed Central PMCID: PMC7462630.

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Liu S, Chen Z, Zhu F, Hu Y. IκB kinase alpha and cancer. J Interferon Cytokine Res. 2012 Apr;32(4):152-8. doi: 10.1089/jir.2011.0107. Epub 2011 Dec 7. Review. PubMed PMID: 22149351; PubMed Central PMCID: PMC3319929.

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Liu B, Willette-Brown J, Liu S, Chen X, Fischer SM, Hu Y. IKKα represses a network of inflammation and proliferation pathways and elevates c-Myc antagonists and differentiation in a dose-dependent manner in the skin. Cell Death Differ. 2011 Dec;18(12):1854-64. doi: 10.1038/cdd.2011.56. Epub 2011 May 13. PubMed PMID: 21566664; PubMed Central PMCID: PMC3214909.

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Park E, Liu B, Xia X, Zhu F, Jami WB, Hu Y. Role of IKKα in skin squamous cell carcinomas. Future Oncol. 2011 Jan;7(1):123-34. doi: 10.2217/fon.10.166. Review. PubMed PMID: 21174543; PubMed Central PMCID: PMC7365019.

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Xia X, Park E, Liu B, Willette-Brown J, Gong W, Wang J, Mitchell D, Fischer SM, Hu Y. Reduction of IKKalpha expression promotes chronic ultraviolet B exposure-induced skin inflammation and carcinogenesis. Am J Pathol. 2010 May;176(5):2500-8. doi: 10.2353/ajpath.2010.091041. Epub 2010 Mar 19. PubMed PMID: 20304950; PubMed Central PMCID: PMC2861114.

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Liu B, Zhu F, Xia X, Park E, Hu Y. A tale of terminal differentiation: IKKalpha, the master keratinocyte regulator. Cell Cycle. 2009 Feb 15;8(4):527-31. doi: 10.4161/cc.8.4.7598. Epub 2009 Feb 10. PubMed PMID: 19197157; PubMed Central PMCID: PMC7243803.

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Zhu F, Park E, Liu B, Xia X, Fischer SM, Hu Y. Critical role of IkappaB kinase alpha in embryonic skin development and skin carcinogenesis. Histol Histopathol. 2009 Feb;24(2):265-71. doi: 10.14670/HH-24.265. Review. PubMed PMID: 19085841; PubMed Central PMCID: PMC7243875.

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Liu B, Xia X, Zhu F, Park E, Carbajal S, Kiguchi K, DiGiovanni J, Fischer SM, Hu Y. IKKalpha is required to maintain skin homeostasis and prevent skin cancer. Cancer Cell. 2008 Sep 9;14(3):212-25. doi: 10.1016/j.ccr.2008.07.017. PubMed PMID: 18772111; PubMed Central PMCID: PMC7263012.

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Park E, Zhu F, Liu B, Xia X, Shen J, Bustos T, Fischer SM, Hu Y. Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas. Cancer Res. 2007 Oct 1;67(19):9158-68. doi: 10.1158/0008-5472.CAN-07-0590. PubMed PMID: 17909021.

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Zhu F, Xia X, Liu B, Shen J, Hu Y, Person M, Hu Y. IKKalpha shields 14-3-3sigma, a G(2)/M cell cycle checkpoint gene, from hypermethylation, preventing its silencing. Mol Cell. 2007 Jul 20;27(2):214-227. doi: 10.1016/j.molcel.2007.05.042. PubMed PMID: 17643371.

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Lomada D, Liu B, Coghlan L, Hu Y, Richie ER. Thymus medulla formation and central tolerance are restored in IKKalpha-/- mice that express an IKKalpha transgene in keratin 5+ thymic epithelial cells. J Immunol. 2007 Jan 15;178(2):829-37. doi: 10.4049/jimmunol.178.2.829. PubMed PMID: 17202344.

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Liu B, Park E, Zhu F, Bustos T, Liu J, Shen J, Fischer SM, Hu Y. A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17202-7. doi: 10.1073/pnas.0604481103. Epub 2006 Nov 1. PubMed PMID: 17079494; PubMed Central PMCID: PMC1859910.

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Ohazama A, Hu Y, Schmidt-Ullrich R, Cao Y, Scheidereit C, Karin M, Sharpe PT. A dual role for Ikk alpha in tooth development. Dev Cell. 2004 Feb;6(2):219-27. doi: 10.1016/s1534-5807(04)00024-3. PubMed PMID: 14960276.

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Senftleben U, Cao Y, Xiao G, Greten FR, Krähn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun SC, Karin M. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science. 2001 Aug 24;293(5534):1495-9. doi: 10.1126/science.1062677. PubMed PMID: 11520989.

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Hu Y, Baud V, Oga T, Kim KI, Yoshida K, Karin M. IKKalpha controls formation of the epidermis independently of NF-kappaB. Nature. 2001 Apr 5;410(6829):710-4. doi: 10.1038/35070605. PubMed PMID: 11287960.

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Yoshida K, Hu Y, Karin M. IkappaB kinase alpha is essential for development of the mammalian cornea and conjunctiva. Invest Ophthalmol Vis Sci. 2000 Nov;41(12):3665-9. PubMed PMID: 11053261.

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Chu WM, Ostertag D, Li ZW, Chang L, Chen Y, Hu Y, Williams B, Perrault J, Karin M. JNK2 and IKKbeta are required for activating the innate response to viral infection. Immunity. 1999 Dec;11(6):721-31. doi: 10.1016/s1074-7613(00)80146-6. PubMed PMID: 10626894.

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Li ZW, Chu W, Hu Y, Delhase M, Deerinck T, Ellisman M, Johnson R, Karin M. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med. 1999 Jun 7;189(11):1839-45. doi: 10.1084/jem.189.11.1839. PubMed PMID: 10359587; PubMed Central PMCID: PMC2193082.

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Hu Y, Baud V, Delhase M, Zhang P, Deerinck T, Ellisman M, Johnson R, Karin M. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science. 1999 Apr 9;284(5412):316-20. doi: 10.1126/science.284.5412.316. PubMed PMID: 10195896.