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Ragle LE, Bruno RD, Boulanger CA, Smith GH. Long-label-retaining mammary epithelial cells are created early in ductal development and distributed throughout the branching ducts. Mech Dev. 2019 Oct;159:103565. doi: 10.1016/j.mod.2019.103565. Epub 2019 Jul 20. PubMed PMID: 31336167; PubMed Central PMCID: PMC6759405.
Mollica PA, Booth-Creech EN, Reid JA, Zamponi M, Sullivan SM, Palmer XL, Sachs PC, Bruno RD. 3D bioprinted mammary organoids and tumoroids in human mammary derived ECM hydrogels. Acta Biomater. 2019 Sep 1;95:201-213. doi: 10.1016/j.actbio.2019.06.017. Epub 2019 Jun 21. PubMed PMID: 31233891; PubMed Central PMCID: PMC6710129.
Bruno RD, Reid J, Sachs PC. The revolution will be open-source: how 3D bioprinting can change 3D cell culture. Oncotarget. 2019 Jul 30;10(46):4724-4726. doi: 10.18632/oncotarget.27099. eCollection 2019 Jul 30. PubMed PMID: 31523386; PubMed Central PMCID: PMC6730589.
Reid JA, Palmer XL, Mollica PA, Northam N, Sachs PC, Bruno RD. A 3D bioprinter platform for mechanistic analysis of tumoroids and chimeric mammary organoids. Sci Rep. 2019 May 16;9(1):7466. doi: 10.1038/s41598-019-43922-z. PubMed PMID: 31097753; PubMed Central PMCID: PMC6522494.
Reid JA, Mollica PA, Bruno RD, Sachs PC. Consistent and reproducible cultures of large-scale 3D mammary epithelial structures using an accessible bioprinting platform. Breast Cancer Res. 2018 Oct 10;20(1):122. doi: 10.1186/s13058-018-1045-4. PubMed PMID: 30305139; PubMed Central PMCID: PMC6180647.
Petrella RA, Mollica PA, Zamponi M, Reid JA, Xiao S, Bruno RD, Sachs PC. 3D bioprinter applied picosecond pulsed electric fields for targeted manipulation of proliferation and lineage specific gene expression in neural stem cells. J Neural Eng. 2018 Oct;15(5):056021. doi: 10.1088/1741-2552/aac8ec. Epub 2018 May 31. PubMed PMID: 29848804; PubMed Central PMCID: PMC6145167.
Wu V, Auchman M, Mollica PA, Sachs PC, Bruno RD. ALDH1A1 positive cells are a unique component of the tonsillar crypt niche and are lost along with NGFR positive stem cells during tumourigenesis. Pathology. 2018 Aug;50(5):524-529. doi: 10.1016/j.pathol.2018.03.002. Epub 2018 Jun 8. PubMed PMID: 29891189.
Mollica PA, Zamponi M, Reid JA, Sharma DK, White AE, Ogle RC, Bruno RD, Sachs PC. Epigenetic alterations mediate iPSC-induced normalization of DNA repair gene expression and TNR stability in Huntington's disease cells. J Cell Sci. 2018 Jul 6;131(13). doi: 10.1242/jcs.215343. PubMed PMID: 29898922.
Sachs PC, Mollica PA, Bruno RD. Tissue specific microenvironments: a key tool for tissue engineering and regenerative medicine. J Biol Eng. 2017;11:34. doi: 10.1186/s13036-017-0077-0. eCollection 2017. Review. PubMed PMID: 29177006; PubMed Central PMCID: PMC5688702.
Bruno RD, Fleming JM, George AL, Boulanger CA, Schedin P, Smith GH. Mammary extracellular matrix directs differentiation of testicular and embryonic stem cells to form functional mammary glands in vivo. Sci Rep. 2017 Jan 10;7:40196. doi: 10.1038/srep40196. PubMed PMID: 28071703; PubMed Central PMCID: PMC5223207.
Kwegyir-Afful AK, Bruno RD, Purushottamachar P, Murigi FN, Njar VC. Galeterone and VNPT55 disrupt Mnk-eIF4E to inhibit prostate cancer cell migration and invasion. FEBS J. 2016 Nov;283(21):3898-3918. doi: 10.1111/febs.13895. Epub 2016 Oct 1. PubMed PMID: 27618366; PubMed Central PMCID: PMC5118139.
Mollica PA, Reid JA, Ogle RC, Sachs PC, Bruno RD. DNA Methylation Leads to DNA Repair Gene Down-Regulation and Trinucleotide Repeat Expansion in Patient-Derived Huntington Disease Cells. Am J Pathol. 2016 Jul;186(7):1967-1976. doi: 10.1016/j.ajpath.2016.03.014. Epub 2016 May 13. PubMed PMID: 27182645.
Reid JA, Mollica PA, Johnson GD, Ogle RC, Bruno RD, Sachs PC. Accessible bioprinting: adaptation of a low-cost 3D-printer for precise cell placement and stem cell differentiation. Biofabrication. 2016 Jun 7;8(2):025017. doi: 10.1088/1758-5090/8/2/025017. PubMed PMID: 27271208.
Godbole AM, Ramalingam S, Ramamurthy VP, Khandelwal A, Bruno RD, Upreti VV, Gediya LK, Purushottamachar P, Mbatia HW, Addya S, Ambulos N, Njar VC. VN/14-1 induces ER stress and autophagy in HP-LTLC human breast cancer cells and has excellent oral pharmacokinetic profile in female Sprague Dawley rats. Eur J Pharmacol. 2014 Jul 5;734:98-104. doi: 10.1016/j.ejphar.2014.04.004. Epub 2014 Apr 12. PubMed PMID: 24726842; PubMed Central PMCID: PMC4047216.
Bruno RD, Smith GH. A potential mechanism for extracellular matrix induction of breast cancer cell normality. Breast Cancer Res. 2014 Feb 17;16(1):302. doi: 10.1186/bcr3617. PubMed PMID: 25927296; PubMed Central PMCID: PMC3978454.
Bruno RD, Boulanger CA, Rosenfield SM, Anderson LH, Lydon JP, Smith GH. Paracrine-rescued lobulogenesis in chimeric outgrowths comprising progesterone-receptor-null mammary epithelium and redirected wild-type testicular cells. J Cell Sci. 2014 Jan 1;127(Pt 1):27-32. doi: 10.1242/jcs.140749. Epub 2013 Nov 4. PubMed PMID: 24190884; PubMed Central PMCID: PMC3874781.
Bruno RD, Rosenfield SM, Smith GH. Late developing mammary tumors and hyperplasia induced by a low-oncogenic variant of mouse mammary tumor virus (MMTV) express genes identical to those induced by canonical MMTV. Mol Cancer. 2013 Jul 18;12:79. doi: 10.1186/1476-4598-12-79. PubMed PMID: 23866257; PubMed Central PMCID: PMC3750450.
Boulanger CA, Bruno RD, Mack DL, Gonzales M, Castro NP, Salomon DS, Smith GH. Embryonic stem cells are redirected to non-tumorigenic epithelial cell fate by interaction with the mammary microenvironment. PLoS One. 2013;8(4):e62019. doi: 10.1371/journal.pone.0062019. Print 2013. PubMed PMID: 23637952; PubMed Central PMCID: PMC3637449.
Bruno RD, Smith GH. Reprogramming non-mammary and cancer cells in the developing mouse mammary gland. Semin Cell Dev Biol. 2012 Jul;23(5):591-8. doi: 10.1016/j.semcdb.2012.03.007. Epub 2012 Mar 10. Review. PubMed PMID: 22430755; PubMed Central PMCID: PMC3381053.
Boulanger CA, Bruno RD, Rosu-Myles M, Smith GH. The mouse mammary microenvironment redirects mesoderm-derived bone marrow cells to a mammary epithelial progenitor cell fate. Stem Cells Dev. 2012 Apr 10;21(6):948-54. doi: 10.1089/scd.2011.0148. Epub 2011 Jul 18. PubMed PMID: 21649558; PubMed Central PMCID: PMC3315755.
Bruno RD, Boulanger CA, Smith GH. Notch-induced mammary tumorigenesis does not involve the lobule-limited epithelial progenitor. Oncogene. 2012 Jan 5;31(1):60-7. doi: 10.1038/onc.2011.215. Epub 2011 Jun 13. PubMed PMID: 21666720; PubMed Central PMCID: PMC3492887.
Bruno RD, Vasaitis TS, Gediya LK, Purushottamachar P, Godbole AM, Ates-Alagoz Z, Brodie AM, Njar VC. Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model. Steroids. 2011 Nov;76(12):1268-79. doi: 10.1016/j.steroids.2011.06.002. Epub 2011 Jun 24. PubMed PMID: 21729712; PubMed Central PMCID: PMC3171567.
Bruno RD, Smith GH. Functional characterization of stem cell activity in the mouse mammary gland. Stem Cell Rev Rep. 2011 Jun;7(2):238-47. doi: 10.1007/s12015-010-9191-9. Review. PubMed PMID: 20853073; PubMed Central PMCID: PMC3492888.
Vasaitis TS, Bruno RD, Njar VC. CYP17 inhibitors for prostate cancer therapy. J Steroid Biochem Mol Biol. 2011 May;125(1-2):23-31. doi: 10.1016/j.jsbmb.2010.11.005. Epub 2010 Nov 17. Review. PubMed PMID: 21092758; PubMed Central PMCID: PMC3047603.
Bruno RD, Smith GH. Role of epithelial stem/progenitor cells in mammary cancer. Gene Expr. 2011;15(3):133-40. doi: 10.3727/105221611x13176664479368. Review. PubMed PMID: 22268295; PubMed Central PMCID: PMC6043825.
Bussard KM, Boulanger CA, Booth BW, Bruno RD, Smith GH. Reprogramming human cancer cells in the mouse mammary gland. Cancer Res. 2010 Aug 1;70(15):6336-43. doi: 10.1158/0008-5472.CAN-10-0591. Epub 2010 Jul 20. PubMed PMID: 20647316; PubMed Central PMCID: PMC3494489.
Bruno RD, Gover TD, Burger AM, Brodie AM, Njar VC. 17alpha-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response. Mol Cancer Ther. 2008 Sep;7(9):2828-36. doi: 10.1158/1535-7163.MCT-08-0336. PubMed PMID: 18790763; PubMed Central PMCID: PMC4040979.
Purushottamachar P, Khandelwal A, Vasaitis TS, Bruno RD, Gediya LK, Njar VC. Potent anti-prostate cancer agents derived from a novel androgen receptor down-regulating agent. Bioorg Med Chem. 2008 Apr 1;16(7):3519-29. doi: 10.1016/j.bmc.2008.02.031. Epub 2008 Feb 14. PubMed PMID: 18316193.
Bruno RD, Njar VC. Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development. Bioorg Med Chem. 2007 Aug 1;15(15):5047-60. doi: 10.1016/j.bmc.2007.05.046. Epub 2007 May 23. Review. PubMed PMID: 17544277; PubMed Central PMCID: PMC1958998.
Purushottamachar P, Khandelwal A, Chopra P, Maheshwari N, Gediya LK, Vasaitis TS, Bruno RD, Clement OO, Njar VC. First pharmacophore-based identification of androgen receptor down-regulating agents: discovery of potent anti-prostate cancer agents. Bioorg Med Chem. 2007 May 15;15(10):3413-21. doi: 10.1016/j.bmc.2007.03.019. Epub 2007 Mar 13. PubMed PMID: 17383188; PubMed Central PMCID: PMC2063997.
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