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    HNF1A HNF1 homeobox A [ Pan troglodytes (chimpanzee) ]

    Gene ID: 744150, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HNF1Aprovided by VGNC
    Official Full Name
    HNF1 homeobox Aprovided by VGNC
    Primary source
    VGNC:VGNC:13130
    Locus tag
    CK820_G0021655
    See related
    Ensembl:ENSPTRG00000005551
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Also known as
    TCF1
    Orthologs
    human mouse all
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    Genomic context

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    See HNF1A in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 10 NC_072408.2 (127795995..127819972)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 12 NC_072410.1 (126408640..126432496)

    Chromosome 10 - NC_072408.2Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein uL11-like Neighboring gene uncharacterized LOC112205017 Neighboring gene uncharacterized LOC107967661 Neighboring gene chromosome 12 C12orf43 homolog Neighboring gene 2'-5'-oligoadenylate synthetase like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in insulin secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in liver development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in pancreas development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hepatocyte nuclear factor 1-alpha
    Names
    transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072408.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      127795995..127819972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009426412.4 → XP_009424687.2  hepatocyte nuclear factor 1-alpha isoform X2

      UniProtKB/TrEMBL
      A0A2J8MDL9, A0A6D2W3K9, H2Q721
      Related
      ENSPTRP00000009420.3
      Conserved Domains (4) summary
      cd00086
      Location:200 → 273
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04813
      Location:549 → 637
      HNF-1A_C; Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus
      pfam04812
      Location:282 → 540
      HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
      pfam04814
      Location:8 → 167
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

    2. XM_001148615.7 → XP_001148615.5  hepatocyte nuclear factor 1-alpha isoform X3

      UniProtKB/TrEMBL
      A0A2J8MDM2
      Conserved Domains (4) summary
      cd00086
      Location:200 → 273
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04813
      Location:542 → 630
      HNF-1A_C; Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus
      pfam04812
      Location:282 → 540
      HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
      pfam04814
      Location:8 → 167
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

    3. XM_016924393.3 → XP_016779882.1  hepatocyte nuclear factor 1-alpha isoform X1

      UniProtKB/TrEMBL
      A0A2I3T729, A0A2J8MDK5, A0A6D2XFZ0
      Related
      ENSPTRP00000084678.1
      Conserved Domains (4) summary
      cd00086
      Location:200 → 273
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04813
      Location:573 → 661
      HNF-1A_C; Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus
      pfam04812
      Location:282 → 540
      HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
      pfam04814
      Location:8 → 167
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus
    Nucleotide Protein
    Heading Accession and Version

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