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    SMAD3 SMAD family member 3 [ Petromyzon marinus (sea lamprey) ]

    Gene ID: 116939938, updated on 1-Aug-2024

    Summary

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    Gene symbol
    SMAD3
    Gene description
    SMAD family member 3
    See related
    EnsemblRapid:ENSPMAG00000000489
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Petromyzon marinus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata; Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon
    Orthologs
    human mouse all
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    Genomic context

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    See SMAD3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    100 current kPetMar1.pri (GCF_010993605.1) 1 NC_046069.1 (27520713..27531640)

    Chromosome 1 - NC_046069.1Genomic Context describing neighboring genes Neighboring gene dymeclin Neighboring gene SMAD family member 6 Neighboring gene very long-chain acyl-CoA synthetase-like Neighboring gene histidine decarboxylase-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_046069.1 Chromosome 1 Reference kPetMar1.pri Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables I-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heteromeric SMAD protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mothers against decapentaplegic homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Petromyzon marinus Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference kPetMar1.pri Primary Assembly

    Genomic

    1. NC_046069.1 Reference kPetMar1.pri Primary Assembly

      Range
      27520713..27531640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_032949028.1 → XP_032804919.1  mothers against decapentaplegic homolog 3 isoform X4

      UniProtKB/TrEMBL
      A0AAJ7WP27, S4R5R4
      Related
      ENSPMAP00000029325.1, ENSPMAT00000079613.1
      Conserved Domains (2) summary
      cd10491
      Location:23 → 160
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:260 → 450
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    2. XM_032949002.1 → XP_032804893.1  mothers against decapentaplegic homolog 3 isoform X1

      UniProtKB/TrEMBL
      A0AAJ7WQD1, S4R5R4
      Conserved Domains (2) summary
      cd10491
      Location:8 → 145
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:245 → 435
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    3. XM_032949011.1 → XP_032804902.1  mothers against decapentaplegic homolog 3 isoform X2

      UniProtKB/TrEMBL
      A0AAJ7SUT8, S4R5R4
      Conserved Domains (2) summary
      cd10491
      Location:8 → 139
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:239 → 429
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    4. XM_032949021.1 → XP_032804912.1  mothers against decapentaplegic homolog 3 isoform X3

      UniProtKB/TrEMBL
      A0AAJ7SST5, S4R5R4
      Related
      ENSPMAP00000000544.2, ENSPMAT00000000545.2
      Conserved Domains (2) summary
      cd10491
      Location:8 → 132
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:232 → 422
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    Nucleotide Protein
    Heading Accession and Version

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