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    mta1 metastasis associated 1 [ Oreochromis niloticus (Nile tilapia) ]

    Gene ID: 100702169, updated on 8-Mar-2024

    Summary

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    Gene symbol
    mta1
    Gene description
    metastasis associated 1
    See related
    Ensembl:ENSONIG00000000969
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Oreochromis niloticus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; Pseudocrenilabrinae; Oreochromini; Oreochromis
    Orthologs
    human zebrafish all
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    Genomic context

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    See mta1 in Genome Data Viewer
    Location:
    chromosome: LG19
    Exon count:
    19
    Annotation release Status Assembly LG Location
    104 current O_niloticus_UMD_NMBU (GCF_001858045.2) LG19 NC_031983.2 (19082673..19126035, complement)
    103 previous assembly ASM185804v2 (GCF_001858045.1) LG19 NC_031983.1 (11678091..11720765)

    Linkage Group LG19 - NC_031983.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102080533 Neighboring gene zinc finger protein 36, C3H type-like 1a Neighboring gene transmembrane protein 229B Neighboring gene cysteine-rich protein 2 Neighboring gene cysteine-rich protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to ionizing radiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuRD complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metastasis-associated protein MTA1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Oreochromis niloticus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference O_niloticus_UMD_NMBU Primary Assembly

    Genomic

    1. NC_031983.2 Reference O_niloticus_UMD_NMBU Primary Assembly

      Range
      19082673..19126035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005477278.4 → XP_005477335.1  metastasis-associated protein MTA1 isoform X1

      See identical proteins and their annotated locations for XP_005477335.1

      UniProtKB/TrEMBL
      I3IX87
      Conserved Domains (6) summary
      smart00717
      Location:269 → 316
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:270 → 315
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      smart00401
      Location:387 → 440
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:391 → 447
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      cd04709
      Location:3 → 171
      BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
      pfam01448
      Location:150 → 202
      ELM2; ELM2 domain

    2. XM_013270066.3 → XP_013125520.1  metastasis-associated protein MTA1 isoform X1

      UniProtKB/TrEMBL
      I3IX87
      Related
      ENSONIP00000001227.2, ENSONIT00000001226.2
      Conserved Domains (6) summary
      smart00717
      Location:269 → 316
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:270 → 315
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      smart00401
      Location:387 → 440
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:391 → 447
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      cd04709
      Location:3 → 171
      BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
      pfam01448
      Location:150 → 202
      ELM2; ELM2 domain

    3. XM_019348835.1 → XP_019204380.1  metastasis-associated protein MTA1 isoform X2

    Nucleotide Protein
    Heading Accession and Version

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