U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    HLTF helicase like transcription factor [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100009232, updated on 10-Oct-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    HLTF
    Gene description
    helicase like transcription factor
    See related
    Ensembl:ENSOCUG00000003520
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Also known as
    RUSH; RUSH-1; SMARCA3
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See HLTF in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 14 NC_067387.1 (43993943..44074290, complement)

    Chromosome 14 - NC_067387.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103350414 Neighboring gene glycogenin 1 Neighboring gene HPS3 biogenesis of lysosomal organelles complex 2 subunit 1 Neighboring gene ceruloplasmin Neighboring gene transmembrane 4 L six family member 18

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_067387.1 Chromosome 14 Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Uteroglobin gene transcription: what's the RUSH? Chilton BS, et al. Ann N Y Acad Sci, 2000. PMID 11193755
    2. Expression of RUSH transcription factors in developing and adult rabbit gonads. Rendon A, et al. Biol Reprod, 2000 Jul. PMID 10859255
    3. Novel elements in the uteroglobin promoter are a functional target for prolactin signaling. Hewetson A, et al. Mol Cell Endocrinol, 1997 Dec 31. PMID 9510061
    4. Quantification of alternatively spliced RUSH mRNA isoforms by QRT-PCR and IP-RP-HPLC analysis: a new approach to measuring regulated splicing efficiency. Robinson CA, et al. Gene, 1997 Oct 1. PMID 9370258
    5. Cloning, characterization, and steroid-dependent posttranscriptional processing of RUSH-1 alpha and beta, two uteroglobin promoter-binding proteins. Hayward-Lester A, et al. Mol Endocrinol, 1996 Nov. PMID 8923460

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prolactin dependent Jak2 phosphorylation of RUSH.
      Title: Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling.
    2. Splice arrays and RT-PCR showed that although most splice variants in RUSH and ATP11B are conserved in human and rabbit, the RFBP isoform is specific to rabbit.
      Title: Conservation of inter-protein binding sites in RUSH and RFBP, an ATP11B isoform.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    helicase-like transcription factor
    Names
    RING-type E3 ubiquitin transferase HLTF
    RUSH 1
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3
    sucrose nonfermenting protein 2-like 3
    NP_001075845.1
    NP_001108200.1
    XP_017202117.1
    XP_017202118.1
    XP_017202119.1
    XP_017202120.1
    XP_017202121.1
    XP_017202122.1
    XP_051714747.1
    XP_051714748.1
    XP_051714749.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082376.1 → NP_001075845.1  helicase-like transcription factor isoform beta

      See identical proteins and their annotated locations for NP_001075845.1

      Status: PROVISIONAL

      Source sequence(s)
      U66565
      UniProtKB/TrEMBL
      A0A5F9DNU6
      Related
      ENSOCUP00000047149.1, ENSOCUT00000049535.1
      Conserved Domains (4) summary
      cd00046
      Location:465 → 585
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00162
      Location:756 → 801
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00176
      Location:463 → 719
      SNF2_N; SNF2 family N-terminal domain
      pfam08797
      Location:60 → 155
      HIRAN; HIRAN domain

    2. NM_001114728.1 → NP_001108200.1  helicase-like transcription factor isoform alpha

      See identical proteins and their annotated locations for NP_001108200.1

      Status: PROVISIONAL

      Source sequence(s)
      U66564
      UniProtKB/Swiss-Prot
      Q95216, Q95217
      UniProtKB/TrEMBL
      A0A5F9CAC2
      Related
      ENSOCUP00000003055.3, ENSOCUT00000003522.4
      Conserved Domains (4) summary
      COG0553
      Location:461 → 1005
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd16509
      Location:755 → 798
      RING-HC_HLTF; RING finger, HC subclass, found in helicase-like transcription factor (HLTF) and similar proteins
      cd18071
      Location:240 → 641
      DEXHc_HLTF1_SMARC3; DEXH-box helicase domain of HLTF1
      pfam08797
      Location:60 → 153
      HIRAN; HIRAN domain

    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NC_067387.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      43993943..44074290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_051858787.1 → XP_051714747.1  helicase-like transcription factor isoform X4

    2. XM_051858789.1 → XP_051714749.1  helicase-like transcription factor isoform X8

    3. XM_017346629.2 → XP_017202118.1  helicase-like transcription factor isoform X2

      UniProtKB/TrEMBL
      A0A5F9CAC2

    4. XM_017346628.2 → XP_017202117.1  helicase-like transcription factor isoform X1

      UniProtKB/TrEMBL
      A0A5F9CAC2

    5. XM_017346631.2 → XP_017202120.1  helicase-like transcription factor isoform X5

      UniProtKB/TrEMBL
      A0A5F9CAC2
      Conserved Domains (5) summary
      cd00046
      Location:475 → 585
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00162
      Location:760 → 805
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00176
      Location:469 → 719
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:833 → 951
      Helicase_C; Helicase conserved C-terminal domain
      pfam08797
      Location:60 → 155
      HIRAN; HIRAN domain

    6. XM_017346630.2 → XP_017202119.1  helicase-like transcription factor isoform X3

      UniProtKB/TrEMBL
      A0A5F9CAC2

    7. XM_017346632.2 → XP_017202121.1  helicase-like transcription factor isoform X7

      UniProtKB/TrEMBL
      A0A5F9CAC2
      Conserved Domains (5) summary
      cd00046
      Location:474 → 584
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00162
      Location:755 → 800
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00176
      Location:468 → 718
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:828 → 946
      Helicase_C; Helicase conserved C-terminal domain
      pfam08797
      Location:60 → 155
      HIRAN; HIRAN domain

    8. XM_051858788.1 → XP_051714748.1  helicase-like transcription factor isoform X6

    9. XM_017346633.2 → XP_017202122.1  helicase-like transcription factor isoform X9

      UniProtKB/TrEMBL
      A0A5F9CAC2

    RNA

    1. XR_007924436.1 RNA Sequence

    2. XR_007924437.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95216.1 GenPept UniProtKB/Swiss-Prot:Q95216

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.