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    HNF1B HNF1 homeobox B [ Nomascus leucogenys (northern white-cheeked gibbon) ]

    Gene ID: 100584568, updated on 8-Mar-2024

    Summary

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    Gene symbol
    HNF1B
    Gene description
    HNF1 homeobox B
    See related
    EnsemblRapid:ENSNLEG00000002919
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Nomascus leucogenys
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Nomascus
    Orthologs
    human mouse all
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    Genomic context

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    See HNF1B in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    103 current Asia_NLE_v1 (GCF_006542625.1) Unplaced Scaffold NW_022095769.1 (5545583..5603735, complement)
    102 previous assembly Nleu_3.0 (GCF_000146795.2) Unplaced Scaffold NW_003501541.1 (2627802..2685884, complement)

    NW_022095769.1Genomic Context describing neighboring genes Neighboring gene synergin gamma Neighboring gene DExD-box helicase 52 Neighboring gene uncharacterized LOC115833570

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in insulin secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in liver development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in pancreas development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hepatocyte nuclear factor 1-beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Nomascus leucogenys Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Asia_NLE_v1 Primary Assembly

    Genomic

    1. NW_022095769.1 Reference Asia_NLE_v1 Primary Assembly

      Range
      5545583..5603735 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012503608.2 → XP_012359062.2  hepatocyte nuclear factor 1-beta isoform X2

      UniProtKB/TrEMBL
      A0A2I3HPI8
      Conserved Domains (3) summary
      cd00086
      Location:206 → 279
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04812
      Location:288 → 524
      HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
      pfam04814
      Location:8 → 174
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    2. XM_003278398.4 → XP_003278446.3  hepatocyte nuclear factor 1-beta isoform X1

      UniProtKB/TrEMBL
      A0A2I3HAA4, A0A2I3HPI8
      Related
      ENSNLEP00000040584.1, ENSNLET00000038771.2
      Conserved Domains (3) summary
      cd00086
      Location:232 → 305
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04812
      Location:314 → 550
      HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
      pfam04814
      Location:8 → 174
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

    3. XM_012503609.2 → XP_012359063.1  hepatocyte nuclear factor 1-beta isoform X3

      UniProtKB/TrEMBL
      A0A2I3HPI8, G1QRR5
      Related
      ENSNLEP00000033689.2, ENSNLET00000038872.2
      Conserved Domains (3) summary
      cd00086
      Location:206 → 279
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam04812
      Location:288 → 425
      HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
      pfam04814
      Location:8 → 174
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
    Nucleotide Protein
    Heading Accession and Version

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