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    NFKB1 nuclear factor kappa B subunit 1 [ Microcebus murinus (gray mouse lemur) ]

    Gene ID: 105874819, updated on 13-Mar-2024

    Summary

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    Gene symbol
    NFKB1
    Gene description
    nuclear factor kappa B subunit 1
    See related
    Ensembl:ENSMICG00000014491
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Microcebus murinus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes; Cheirogaleidae; Microcebus
    Orthologs
    human mouse all
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    Genomic context

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    See NFKB1 in Genome Data Viewer
    Location:
    chromosome: 29
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    101 current Mmur_3.0 (GCF_000165445.2) 29 NC_033688.1 (12464787..12581071, complement)
    100 previous assembly Mmur_2.0 (GCF_000165445.1) Unplaced Scaffold NW_012196441.1 (728833..845079, complement)

    Chromosome 29 - NC_033688.1Genomic Context describing neighboring genes Neighboring gene mannosidase beta Neighboring gene 3-hydroxybutyrate dehydrogenase type 2 pseudogene Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC109730149 Neighboring gene uncharacterized LOC105874820 Neighboring gene uncharacterized LOC105874822 Neighboring gene uncharacterized LOC105874821

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to cytokine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear factor NF-kappa-B p105 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Microcebus murinus Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmur_3.0 Primary Assembly

    Genomic

    1. NC_033688.1 Reference Mmur_3.0 Primary Assembly

      Range
      12464787..12581071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012770964.2 → XP_012626418.1  nuclear factor NF-kappa-B p105 subunit isoform X1

      UniProtKB/TrEMBL
      A0A8B7GUJ8, A0A8C5YEE1
      Conserved Domains (8) summary
      cd07935
      Location:42 → 243
      RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
      cd00204
      Location:619 → 773
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:250 → 351
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:860 → 934
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      pfam12796
      Location:629 → 723
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:586 → 645
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:717 → 769
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:585 → 622
      ANK; ANK repeat [structural motif]

    2. XM_012770966.2 → XP_012626420.1  nuclear factor NF-kappa-B p105 subunit isoform X3

      UniProtKB/TrEMBL
      A0A8B7GST7, A0A8C5YEE1
      Conserved Domains (8) summary
      cd07935
      Location:41 → 242
      RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
      cd00204
      Location:618 → 772
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:249 → 350
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:859 → 933
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      pfam12796
      Location:628 → 722
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:585 → 644
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:716 → 768
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:584 → 621
      ANK; ANK repeat [structural motif]

    3. XM_012770967.2 → XP_012626421.1  nuclear factor NF-kappa-B p105 subunit isoform X4

      UniProtKB/TrEMBL
      A0A8B7GST8, A0A8C5YEE1
      Conserved Domains (8) summary
      cd07935
      Location:42 → 243
      RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
      cd00204
      Location:584 → 738
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:250 → 351
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:825 → 899
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      pfam12796
      Location:594 → 688
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:551 → 610
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:682 → 734
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:550 → 587
      ANK; ANK repeat [structural motif]

    4. XM_012770965.2 → XP_012626419.1  nuclear factor NF-kappa-B p105 subunit isoform X2

      UniProtKB/TrEMBL
      A0A8B7GT23, A0A8C5YEE1
      Conserved Domains (8) summary
      cd07935
      Location:42 → 243
      RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
      cd00204
      Location:619 → 773
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:250 → 351
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:859 → 933
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      pfam12796
      Location:629 → 723
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:586 → 645
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:717 → 769
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:585 → 622
      ANK; ANK repeat [structural motif]

    5. XM_012770970.2 → XP_012626424.1  nuclear factor NF-kappa-B p105 subunit isoform X7

      UniProtKB/TrEMBL
      A0A8B7GT28, A0A8C5YEE1
      Conserved Domains (8) summary
      cd07935
      Location:41 → 242
      RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
      cd00204
      Location:568 → 722
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:249 → 350
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:808 → 882
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      pfam12796
      Location:578 → 672
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:535 → 594
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:666 → 718
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:534 → 571
      ANK; ANK repeat [structural motif]

    6. XM_012770968.2 → XP_012626422.1  nuclear factor NF-kappa-B p105 subunit isoform X6

      UniProtKB/TrEMBL
      A0A8C5V1T8, A0A8C5YEE1
      Related
      ENSMICP00000013219.2, ENSMICT00000014503.3
      Conserved Domains (8) summary
      cd07935
      Location:42 → 243
      RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
      cd00204
      Location:569 → 723
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:250 → 351
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:809 → 883
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      pfam12796
      Location:579 → 673
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:536 → 595
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:667 → 719
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:535 → 572
      ANK; ANK repeat [structural motif]

    7. XM_020284607.1 → XP_020140196.1  nuclear factor NF-kappa-B p105 subunit isoform X5

      UniProtKB/TrEMBL
      A0A8B7WXP7, A0A8C5YEE1
      Conserved Domains (6) summary
      cd07935
      Location:42 → 243
      RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
      COG0666
      Location:505 → 652
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:569 → 723
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:250 → 351
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:810 → 884
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      sd00045
      Location:535 → 572
      ANK; ANK repeat [structural motif]

    8. XM_012770971.2 → XP_012626425.1  nuclear factor NF-kappa-B p105 subunit isoform X9

      UniProtKB/TrEMBL
      A0A8B7GSU3
      Conserved Domains (7) summary
      cd00204
      Location:386 → 540
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:17 → 118
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:627 → 701
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      pfam12796
      Location:396 → 490
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:353 → 412
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:484 → 536
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:352 → 389
      ANK; ANK repeat [structural motif]

    9. XM_020284608.1 → XP_020140197.1  nuclear factor NF-kappa-B p105 subunit isoform X8

      UniProtKB/TrEMBL
      A0A8B7WXP6, A0A8C5YEE1
      Conserved Domains (6) summary
      COG0666
      Location:448 → 613
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:530 → 684
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:161 → 262
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cd08797
      Location:771 → 845
      Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
      sd00045
      Location:496 → 533
      ANK; ANK repeat [structural motif]
      cl08275
      Location:1 → 154
      RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
    Nucleotide Protein
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