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    MTA3 metastasis associated 1 family member 3 [ Microcebus murinus (gray mouse lemur) ]

    Gene ID: 105866924, updated on 13-Mar-2024

    Summary

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    Gene symbol
    MTA3
    Gene description
    metastasis associated 1 family member 3
    See related
    Ensembl:ENSMICG00000006534
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Microcebus murinus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes; Cheirogaleidae; Microcebus
    Orthologs
    human mouse all
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    Genomic context

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    See MTA3 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    101 current Mmur_3.0 (GCF_000165445.2) 8 NC_033667.1 (122097418..122342240, complement)
    100 previous assembly Mmur_2.0 (GCF_000165445.1) Unplaced Scaffold NW_012195575.1 (6558389..6801480, complement)

    Chromosome 8 - NC_033667.1Genomic Context describing neighboring genes Neighboring gene 3-hydroxyanthranilate 3,4-dioxygenase Neighboring gene oxoeicosanoid receptor 1 Neighboring gene C-Myc-binding protein pseudogene Neighboring gene potassium voltage-gated channel modifier subfamily G member 3 Neighboring gene cytochrome c oxidase subunit 7A-related protein, mitochondrial

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuRD complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metastasis-associated protein MTA3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Microcebus murinus Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmur_3.0 Primary Assembly

    Genomic

    1. NC_033667.1 Reference Mmur_3.0 Primary Assembly

      Range
      122097418..122342240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012756584.2 → XP_012612038.1  metastasis-associated protein MTA3 isoform X1

      UniProtKB/TrEMBL
      A0A8B7FSK7, A0A8C5W8L0
      Conserved Domains (6) summary
      smart00717
      Location:339 → 386
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:340 → 385
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      smart00401
      Location:446 → 495
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:448 → 496
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      cd04709
      Location:80 → 240
      BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
      pfam01448
      Location:220 → 271
      ELM2; ELM2 domain

    2. XM_012756591.2 → XP_012612045.1  metastasis-associated protein MTA3 isoform X2

      UniProtKB/TrEMBL
      A0A8B7FSK1, A0A8C5W8L0
      Related
      ENSMICP00000045160.1, ENSMICT00000059070.1
      Conserved Domains (6) summary
      smart00717
      Location:339 → 386
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:340 → 385
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      smart00401
      Location:445 → 494
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:447 → 495
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      cd04709
      Location:80 → 240
      BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
      pfam01448
      Location:220 → 271
      ELM2; ELM2 domain

    3. XM_012756600.2 → XP_012612054.1  metastasis-associated protein MTA3 isoform X5

      UniProtKB/TrEMBL
      A0A8B7FSM2, A0A8C5W8L0
      Related
      ENSMICP00000036185.2, ENSMICT00000033761.2
      Conserved Domains (6) summary
      smart00717
      Location:290 → 337
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:291 → 336
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      smart00401
      Location:397 → 446
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:399 → 447
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      cd04709
      Location:24 → 191
      BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
      pfam01448
      Location:171 → 222
      ELM2; ELM2 domain

    4. XM_020288595.1 → XP_020144184.1  metastasis-associated protein MTA3 isoform X3

      UniProtKB/TrEMBL
      A0A8B7X9K2, A0A8C5W8L0
      Conserved Domains (4) summary
      cd11661
      Location:291 → 336
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      smart00401
      Location:396 → 445
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd04709
      Location:24 → 191
      BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
      pfam01448
      Location:171 → 222
      ELM2; ELM2 domain

    5. XM_012756616.2 → XP_012612070.1  metastasis-associated protein MTA3 isoform X4

      UniProtKB/TrEMBL
      A0A8B7FSN6, A0A8C5UWE9
      Related
      ENSMICP00000005967.3, ENSMICT00000006529.3
      Conserved Domains (6) summary
      smart00717
      Location:213 → 260
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:214 → 259
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      smart00401
      Location:320 → 369
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:322 → 370
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam01448
      Location:94 → 145
      ELM2; ELM2 domain
      cl02608
      Location:2 → 114
      BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...

    RNA

    1. XR_001152086.2 RNA Sequence

      Related
      ENSMICT00000039150.2
    Nucleotide Protein
    Heading Accession and Version

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