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    STAT1 signal transducer and activator of transcription 1 [ Equus caballus (horse) ]

    Gene ID: 100069633, updated on 17-Aug-2024

    Summary

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    Official Symbol
    STAT1provided by VGNC
    Official Full Name
    signal transducer and activator of transcription 1provided by VGNC
    Primary source
    VGNC:VGNC:23663
    See related
    Ensembl:ENSECAG00000009039
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See STAT1 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 18 NC_009161.3 (67414096..67452831, complement)

    Chromosome 18 - NC_009161.3Genomic Context describing neighboring genes Neighboring gene serine protease 58 Neighboring gene uncharacterized LOC111768773 Neighboring gene uncharacterized LOC111768771 Neighboring gene glutaminase Neighboring gene uncharacterized LOC111768772 Neighboring gene signal transducer and activator of transcription 4 Neighboring gene uncharacterized LOC111768774 Neighboring gene myosin IB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009161.3 Chromosome 18 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in type I interferon-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    signal transducer and activator of transcription 1-alpha/beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009161.3 Reference EquCab3.0 Primary Assembly

      Range
      67414096..67452831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001499369.6 → XP_001499419.2  signal transducer and activator of transcription 1-alpha/beta

      See identical proteins and their annotated locations for XP_001499419.2

      UniProtKB/TrEMBL
      A0A5F5PXT6, A0A9L0RKJ5
      Related
      ENSECAP00000053438.2, ENSECAT00000074269.2
      Conserved Domains (5) summary
      cd10372
      Location:557 → 707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2 → 121
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:139 → 315
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:317 → 566
      STAT_bind; STAT protein, DNA binding domain
      pfam12162
      Location:715 → 739
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain

    2. XM_023622233.1 → XP_023478001.1  signal transducer and activator of transcription 1-alpha/beta

      UniProtKB/TrEMBL
      A0A5F5PXT6, A0A9L0RKJ5
      Conserved Domains (5) summary
      cd10372
      Location:557 → 707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2 → 121
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:139 → 315
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:317 → 566
      STAT_bind; STAT protein, DNA binding domain
      pfam12162
      Location:715 → 739
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    Nucleotide Protein
    Heading Accession and Version

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