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    hox1 homeobox transcription factor Hox1 [ Ciona intestinalis (vase tunicate) ]

    Gene ID: 445718, updated on 21-Dec-2023

    Summary

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    Gene symbol
    hox1
    Gene description
    homeobox transcription factor Hox1
    See related
    Ensembl:ENSCING00000001273
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Ciona intestinalis
    Lineage
    Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia; Cionidae; Ciona
    Also known as
    Ci-Hox1
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    Genomic context

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    See hox1 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    104 current KH (GCF_000224145.3) Unplaced Scaffold NW_004190417.1 (182359..188436, complement)

    NW_004190417.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108950286 Neighboring gene F-box/LRR-repeat protein 15 Neighboring gene uncharacterized LOC113475077 Neighboring gene uncharacterized LOC100186803 Neighboring gene transcription factor protein Neighboring gene opsin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_004190417 Unplaced Scaffold Reference KH Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hox-mediated endodermal identity patterns pharyngeal muscle formation in the chordate pharynx. Yoshida K, et al. Development, 2017 May 1. PMID 28289133
    2. Retinoic acid-driven Hox1 is required in the epidermis for forming the otic/atrial placodes during ascidian metamorphosis. Sasakura Y, et al. Development, 2012 Jun. PMID 22573621
    3. Epidermal expression of Hox1 is directly activated by retinoic acid in the Ciona intestinalis embryo. Kanda M, et al. Dev Biol, 2009 Nov 15. PMID 19782671
    4. Unusual number and genomic organization of Hox genes in the tunicate Ciona intestinalis. Spagnuolo A, et al. Gene, 2003 May 8. PMID 12758123
    5. Gene expression profiles of transcription factors and signaling molecules in the ascidian embryo: towards a comprehensive understanding of gene networks. Imai KS, et al. Development, 2004 Aug. PMID 15269171

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hox1 is essential for the establishment of Aanterior-posterior axial identity of the endostyle, a major structure of the pharyngeal endoderm, in the ascidian Ciona intestinalis.
      Title: Hox-mediated endodermal identity patterns pharyngeal muscle formation in the chordate pharynx.
    2. Retinoic acid mediated-Hox1 in the epidermal ectoderm played a key role in the acquisition of the otic placode during chordate evolution.
      Title: Retinoic acid-driven Hox1 is required in the epidermis for forming the otic/atrial placodes during ascidian metamorphosis.
    3. results indicate that retinoic acid directly activates the epidermal enhancer of Ci-Hox1. This is the first demonstration that retinoic acid is necessary for endogenous gene expression in ascidian embryos
      Title: Epidermal expression of Hox1 is directly activated by retinoic acid in the Ciona intestinalis embryo.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homeobox transcription factor Hox1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128861.1 → NP_001122333.1  homeobox transcription factor Hox1

      See identical proteins and their annotated locations for NP_001122333.1

      Status: PROVISIONAL

      Source sequence(s)
      AB210490
      UniProtKB/TrEMBL
      A0A1W2VQU6, Q4H3D2
      Related
      ENSCINP00000002468, ENSCINT00000002468
      Conserved Domains (1) summary
      pfam00046
      Location:238 → 290
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: Ciona intestinalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference KH Primary Assembly

    Genomic

    1. NW_004190417.1 Reference KH Primary Assembly

      Range
      182359..188436 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018815614.2 → XP_018671159.1  homeobox transcription factor Hox1 isoform X1

      UniProtKB/TrEMBL
      A0A1W5BJS8, F6ZW63
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials