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CDC6 cell division cycle 6 [ Homo sapiens (human) ]

Gene ID: 990, updated on 14-Nov-2024

Summary

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Official Symbol
CDC6provided by HGNC
Official Full Name
cell division cycle 6provided by HGNC
Primary source
HGNC:HGNC:1744
See related
Ensembl:ENSG00000094804 MIM:602627; AllianceGenome:HGNC:1744
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDC18L; HsCDC6; MGORS5; HsCDC18
Summary
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 5.8), lymph node (RPKM 4.9) and 20 other tissues See more
Orthologs
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Genomic context

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See CDC6 in Genome Data Viewer
Location:
17q21.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (40287879..40304657)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (41151103..41168161)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38444131..38460909)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38350695-38351195 Neighboring gene microRNA 6867 Neighboring gene Sharpr-MPRA regulatory region 10842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12134 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:38375397-38376175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38380779-38381350 Neighboring gene WAS/WASL interacting protein family member 2 Neighboring gene RNY4 pseudogene 8 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:38437298-38438234 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:38438235-38439169 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38443891-38444698 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38447656-38448242 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:38452145-38452660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38464859-38465744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38465745-38466628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38468218-38468718 Neighboring gene uncharacterized LOC105371934 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:38473742-38473951 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38477303-38477887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12143 Neighboring gene retinoic acid receptor alpha Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38497666-38498244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38498280-38498830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38498831-38499380 Neighboring gene RARA antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Replication Protein Cdc6 Suppresses Centrosome Over-Duplication in a Manner Independent of Its ATPase Activity. Kim GS, et al. Mol Cells, 2017 Dec 31. PMID 29237113, Free PMC Article
  2. CDC6 is up-regulated and a poor prognostic signature in glioblastoma multiforme. Zhao H, et al. Clin Transl Oncol, 2021 Mar. PMID 32661826
  3. A pilot study of cdc6 as a biomarker for circulating tumor cells in patients with lung cancer. An C, et al. J Clin Lab Anal, 2020 Jun. PMID 32249466, Free PMC Article
  4. Cdc6 as a novel target in cancer: Oncogenic potential, senescence and subcellular localisation. Lim N, et al. Int J Cancer, 2020 Sep 15. PMID 32010971, Free PMC Article
  5. Destabilization of CDC6 upon DNA damage is dependent on neddylation but independent of Cullin E3 ligases. Tan CY, et al. Int J Biochem Cell Biol, 2013 Jul. PMID 23597704

See all (182) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDC6 may serve as an indicator of lung adenocarcinoma prognosis and progression based on TCGA and GEO data mining and experimental analyses.
    Title: CDC6 may serve as an indicator of lung adenocarcinoma prognosis and progression based on TCGA and GEO data mining and experimental analyses.
  2. Role of TOP2A and CDC6 in liver cancer.
    Title: Role of TOP2A and CDC6 in liver cancer.
  3. CDC6 is a prognostic biomarker and correlated with immune infiltrates in glioma.
    Title: CDC6 is a prognostic biomarker and correlated with immune infiltrates in glioma.
  4. FOXM1 Promotes Malignant Proliferation of Esophageal Squamous Cell Carcinoma Through Transcriptional Activating CDC6.
    Title: FOXM1 Promotes Malignant Proliferation of Esophageal Squamous Cell Carcinoma Through Transcriptional Activating CDC6.
  5. The Effect of High CDC6 Levels on Predicting Poor Prognosis in Colorectal Cancer.
    Title: The Effect of High CDC6 Levels on Predicting Poor Prognosis in Colorectal Cancer.
  6. MiR-128-3p suppresses tumor proliferation and metastasis via targeting CDC6 in hepatocellular carcinoma cells.
    Title: MiR-128-3p suppresses tumor proliferation and metastasis via targeting CDC6 in hepatocellular carcinoma cells.
  7. UHRF1 promotes androgen receptor-regulated CDC6 transcription and anti-androgen receptor drug resistance in prostate cancer through KDM4C-Mediated chromatin modifications.
    Title: UHRF1 promotes androgen receptor-regulated CDC6 transcription and anti-androgen receptor drug resistance in prostate cancer through KDM4C-Mediated chromatin modifications.
  8. CDC6 is up-regulated and a poor prognostic signature in glioblastoma multiforme.
    Title: CDC6 is up-regulated and a poor prognostic signature in glioblastoma multiforme.
  9. Interactome analysis of gene expression profiles identifies CDC6 as a potential therapeutic target modified by miR-215-5p in hepatocellular carcinoma.
    Title: Interactome analysis of gene expression profiles identifies CDC6 as a potential therapeutic target modified by miR-215-5p in hepatocellular carcinoma.
  10. Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication.
    Title: Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication.
Submit: New GeneRIF Correction See all GeneRIFs (93)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Meier-Gorlin syndrome 5
MedGen: C3151126 OMIM: 613805 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nucleotide binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication checkpoint signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to angiotensin IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to vasopressin IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA replication TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cell population proliferation TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of chromosome segregation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic metaphase/anaphase transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in traversing start control point of mitotic cell cycle TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
  
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
  
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cell division control protein 6 homolog
Names
CDC6 cell division cycle 6 homolog
CDC6-related protein
cdc18-related protein
cell division cycle 6 homolog
p62(cdc6)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028240.2 RefSeqGene

    Range
    5001..21779
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1257

mRNA and Protein(s)

  1. NM_001254.4 → NP_001245.1  cell division control protein 6 homolog

    See identical proteins and their annotated locations for NP_001245.1

    Status: REVIEWED

    Source sequence(s)
    AC080112, AK313620, BC025232
    Consensus CDS
    CCDS11365.1
    UniProtKB/Swiss-Prot
    Q8TB30, Q99741
    UniProtKB/TrEMBL
    B2R935
    Related
    ENSP00000209728.4, ENST00000209728.9
    Conserved Domains (3) summary
    smart01074
    Location:465 → 545
    Cdc6_C; CDC6, C terminal
    COG1474
    Location:168 → 547
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam13191
    Location:171 → 314
    AAA_16; AAA ATPase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    40287879..40304657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525542.2 → XP_011523844.1  cell division control protein 6 homolog isoform X1

    See identical proteins and their annotated locations for XP_011523844.1

    UniProtKB/TrEMBL
    B2R935
    Conserved Domains (3) summary
    smart01074
    Location:505 → 585
    Cdc6_C; CDC6, C terminal
    COG1474
    Location:168 → 587
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam13191
    Location:171 → 314
    AAA_16; AAA ATPase domain

  2. XM_047437207.1 → XP_047293163.1  cell division control protein 6 homolog isoform X2

    UniProtKB/Swiss-Prot
    Q8TB30, Q99741

  3. XM_011525541.3 → XP_011523843.1  cell division control protein 6 homolog isoform X1

    See identical proteins and their annotated locations for XP_011523843.1

    UniProtKB/TrEMBL
    B2R935
    Conserved Domains (3) summary
    smart01074
    Location:505 → 585
    Cdc6_C; CDC6, C terminal
    COG1474
    Location:168 → 587
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam13191
    Location:171 → 314
    AAA_16; AAA ATPase domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    41151103..41168161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318058.1 → XP_054174033.1  cell division control protein 6 homolog isoform X1

  2. XM_054318059.1 → XP_054174034.1  cell division control protein 6 homolog isoform X2

  3. XM_054318057.1 → XP_054174032.1  cell division control protein 6 homolog isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99741.1 GenPept UniProtKB/Swiss-Prot:Q99741

Gene LinkOut

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