U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CD72 CD72 molecule [ Homo sapiens (human) ]

Gene ID: 971, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
CD72provided by HGNC
Official Full Name
CD72 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1696
See related
Ensembl:ENSG00000137101 MIM:107272; AllianceGenome:HGNC:1696
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LYB2; CD72b
Summary
Enables transmembrane signaling receptor activity. Involved in negative regulation of B cell receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in lymph node (RPKM 32.2), spleen (RPKM 30.4) and 4 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CD72 in Genome Data Viewer
Location:
9p13.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (35609982..35646857, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (35630646..35667363, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35609979..35618410, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein S29 pseudogene 17 Neighboring gene Sharpr-MPRA regulatory region 2201 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28326 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19866 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19867 Neighboring gene Sharpr-MPRA regulatory region 203 Neighboring gene testis associated actin remodelling kinase 1 Neighboring gene microRNA 4667 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:35615974-35616825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28327 Neighboring gene uncharacterized LOC124902148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28328 Neighboring gene uncharacterized LOC101926948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28330 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19870 Neighboring gene signaling threshold regulating transmembrane adaptor 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:35657053-35657561 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:35657562-35658069 Neighboring gene RNA component of mitochondrial RNA processing endoribonuclease

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CD72 is a pan-tumor antigen associated to pediatric acute leukemia. Buldini B, et al. Cytometry A, 2023 Dec. PMID 37876342
  2. CD72 polymorphism associated with child-onset of idiopathic thrombocytopenic purpura in Chinese patients. Xu J, et al. J Clin Immunol, 2008 May. PMID 18071878
  3. Increased mutations of CD72 transcript in B-lymphocytes from adolescent patients with systemic lupus erythematosus. Kaneko U, et al. Pediatr Allergy Immunol, 2006 Dec. PMID 17121583
  4. CD72-mediated suppression of human naive B cell differentiation by down-regulating X-box binding protein 1. Yamazaki T, et al. Eur J Immunol, 2005 Aug. PMID 16047337
  5. Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum. Hitomi Y, et al. BMC Immunol, 2012 Dec 26. PMID 23268649, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CD72 is a pan-tumor antigen associated to pediatric acute leukemia.
    Title: CD72 is a pan-tumor antigen associated to pediatric acute leukemia.
  2. CD72, a new immune checkpoint molecule, is a novel prognostic biomarker for kidney renal clear cell carcinoma.
    Title: CD72, a new immune checkpoint molecule, is a novel prognostic biomarker for kidney renal clear cell carcinoma.
  3. CD72-semaphorin3A axis: A new regulatory pathway in systemic lupus erythematosus.
    Title: CD72-semaphorin3A axis: A new regulatory pathway in systemic lupus erythematosus.
  4. Blockage of CD72 reduces B cell proliferation in immune thrombocytopenic purpura, involving interleukin 1 and macrophage migration inhibitory factor secretion.
    Title: Blockage of CD72 reduces B cell proliferation in immune thrombocytopenic purpura, involving interleukin 1 and macrophage migration inhibitory factor secretion.
  5. CD40 and CD72 expression and prognostic values among children with systemic lupus erythematosus: a case-control study.
    Title: CD40 and CD72 expression and prognostic values among children with systemic lupus erythematosus: a case-control study.
  6. A regulatory role for CD72 expression on B cells and increased soluble CD72 in primary Sjogren's syndrome.
    Title: A regulatory role for CD72 expression on B cells and increased soluble CD72 in primary Sjogren's syndrome.
  7. Interferon-alpha-induced CD100 expression on naive CD8(+) T cells enhances antiviral responses to hepatitis C infection through CD72 signal transduction.
    Title: Interferon-α-induced CD100 on naïve CD8(+) T cells enhances antiviral responses to hepatitis C infection through CD72 signal transduction.
  8. Increased soluble CD72 in systemic lupus erythematosus is in association with disease activity and lupus nephritis
    Title: Increased soluble CD72 in systemic lupus erythematosus is in association with disease activity and lupus nephritis.
  9. CD72 expression on activated B cells of SLE patients was significantly lower than that of normal controls. sema3A enhanced CD72 expression of B cells, but it was still lower in SLE patients than in normal individuals.
    Title: A regulatory role for CD72 expression on B cells in systemic lupus erythematosus.
  10. data demonstrated aberrant expression of CD72 exists on B cells of myasthenia gravis and multiple sclerosis patients and expression level of CD72 molecule has a significantly negative correlation with anti-AchR antibody levels in myasthenia gravis
    Title: Modulation of B cell regulatory molecules CD22 and CD72 in myasthenia gravis and multiple sclerosis.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding TAS
Traceable Author Statement
more info
 PubMed 
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane signaling receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
B-cell differentiation antigen CD72
Names
CD72 antigen
lyb-2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001782.3 → NP_001773.1  B-cell differentiation antigen CD72

    See identical proteins and their annotated locations for NP_001773.1

    Status: VALIDATED

    Source sequence(s)
    AL357874, BC030227, M54992
    Consensus CDS
    CCDS6581.1
    UniProtKB/Swiss-Prot
    P21854
    UniProtKB/TrEMBL
    Q5TLF7, Q5TLG0, Q5TLG3
    Related
    ENSP00000259633.4, ENST00000259633.9
    Conserved Domains (2) summary
    smart00034
    Location:233 → 351
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    TIGR04211
    Location:117 → 219
    SH3_and_anchor; SH3 domain protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    35609982..35646857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424154.1 → XP_047280110.1  B-cell differentiation antigen CD72 isoform X2

  2. XM_047424155.1 → XP_047280111.1  B-cell differentiation antigen CD72 isoform X2

  3. XM_006716893.3 → XP_006716956.1  B-cell differentiation antigen CD72 isoform X1

    UniProtKB/TrEMBL
    Q5TLF7, Q5TLG0
    Conserved Domains (2) summary
    pfam08826
    Location:168 → 223
    DMPK_coil; DMPK coiled coil domain like
    smart00034
    Location:233 → 319
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

  4. XM_047424156.1 → XP_047280112.1  B-cell differentiation antigen CD72 isoform X3

  5. XM_047424157.1 → XP_047280113.1  B-cell differentiation antigen CD72 isoform X4

    Related
    ENSP00000367688.1, ENST00000378431.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    35630646..35667363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364281.1 → XP_054220256.1  B-cell differentiation antigen CD72 isoform X2

  2. XM_054364282.1 → XP_054220257.1  B-cell differentiation antigen CD72 isoform X2

  3. XM_054364280.1 → XP_054220255.1  B-cell differentiation antigen CD72 isoform X1

  4. XM_054364283.1 → XP_054220258.1  B-cell differentiation antigen CD72 isoform X3

  5. XM_054364284.1 → XP_054220259.1  B-cell differentiation antigen CD72 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21854.1 GenPept UniProtKB/Swiss-Prot:P21854

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous