NCOR2 nuclear receptor corepressor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NCOR2provided by HGNC
Official Full Name: nuclear receptor corepressor 2provided by HGNC
Primary source: HGNC:HGNC:7673
See related: Ensembl:ENSG00000196498 MIM:600848; AllianceGenome:HGNC:7673
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SMRT; TRAC; CTG26; SMRTE; TRAC1; N-CoR2; TNRC14; TRAC-1; SMAP270; SMRTE-tau
Summary: This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]
Expression: Ubiquitous expression in fat (RPKM 14.9), lung (RPKM 14.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q24.31

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (124324415..124567612, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (124326823..124572906, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (124808961..125052158, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Keratin-Positive Giant Cell-Rich Tumor of Bone Harboring an HMGA2::NCOR2 Fusion: Two Cases, Including a Patient With Metastatic Disease, and Review of the Literature.
Title: Keratin-Positive Giant Cell-Rich Tumor of Bone Harboring an HMGA2::NCOR2 Fusion: Two Cases, Including a Patient With Metastatic Disease, and Review of the Literature.
Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation.
Title: Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation.
Screening of organoids derived from patients with breast cancer implicates the repressor NCOR2 in cytotoxic stress response and antitumor immunity.
Title: Screening of organoids derived from patients with breast cancer implicates the repressor NCOR2 in cytotoxic stress response and antitumor immunity.
NCOR2 is a novel candidate gene for migraine-epilepsy phenotype.
Title: NCOR2 is a novel candidate gene for migraine-epilepsy phenotype.
Recurrent Fusion of the Genes for High-mobility Group AT-hook 2 (HMGA2) and Nuclear Receptor Co-repressor 2 (NCOR2) in Osteoclastic Giant Cell-rich Tumors of Bone.
Title: Recurrent Fusion of the Genes for High-mobility Group AT-hook 2 (HMGA2) and Nuclear Receptor Co-repressor 2 (NCOR2) in Osteoclastic Giant Cell-rich Tumors of Bone.
Methylation statuses of NCOR2, PARK2, and ZSCAN12 signify densities of tumor-infiltrating lymphocytes in gastric carcinoma.
Title: Methylation statuses of NCOR2, PARK2, and ZSCAN12 signify densities of tumor-infiltrating lymphocytes in gastric carcinoma.
KPNA1 regulates nuclear import of NCOR2 splice variant BQ323636.1 to confer tamoxifen resistance in breast cancer.
Title: KPNA1 regulates nuclear import of NCOR2 splice variant BQ323636.1 to confer tamoxifen resistance in breast cancer.
Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer.
Title: Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer.
Low NCOR2 levels in multiple myeloma patients drive multidrug resistance via MYC upregulation.
Title: Low NCOR2 levels in multiple myeloma patients drive multidrug resistance via MYC upregulation.
Recurrent novel HMGA2-NCOR2 fusions characterize a subset of keratin-positive giant cell-rich soft tissue tumors.
Title: Recurrent novel HMGA2-NCOR2 fusions characterize a subset of keratin-positive giant cell-rich soft tissue tumors.

Submit: New GeneRIF Correction See all GeneRIFs (91)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies new disease loci for isolated clubfoot. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of nuclear receptor corepressor 2 (NCOR2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-D60472 (e-PCR)
- UniSTS:75524

RH45082 (e-PCR)
- UniSTS:11308

D1S1361 (e-PCR)
- UniSTS:149557

SHGC-147666 (e-PCR)
- UniSTS:175940

SHGC-148126 (e-PCR)
- UniSTS:176214

SHGC-80723 (e-PCR)
- UniSTS:102258

SHGC-145659 (e-PCR)
- UniSTS:174711

RH79644 (e-PCR)
- UniSTS:85370

G16002 (e-PCR)
- UniSTS:67200

SHGC-146890 (e-PCR)
- UniSTS:175494

G65579 (e-PCR)
- UniSTS:225423

SHGC-149920 (e-PCR)
- UniSTS:177305

D12S1611 (e-PCR)
- UniSTS:9893

AF021128 (e-PCR)
- UniSTS:38314

G27367 (e-PCR)
- UniSTS:70315

SHGC-149122 (e-PCR)
- UniSTS:176812

SHGC-79687 (e-PCR)
- UniSTS:102068

RH80134 (e-PCR)
- UniSTS:84933

STS-AA007694 (e-PCR)
- UniSTS:82898

RH78821 (e-PCR)
- UniSTS:80607

D12S1612 (e-PCR)
- UniSTS:64992

RH121123 (e-PCR)
- UniSTS:134118

RH80812 (e-PCR)
- UniSTS:89077

RH79918 (e-PCR)
- UniSTS:89078

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables Notch binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear glucocorticoid receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear retinoid X receptor binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cerebellum development	IEA Inferred from Electronic Annotation more info
involved_in estrous cycle	IEA Inferred from Electronic Annotation more info
involved_in lactation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of androgen receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of miRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cellular ketone metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription repressor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nuclear receptor corepressor 2

Names: CTG repeat protein 26; T3 receptor-associating factor; silencing mediator for retinoid and thyroid hormone receptors; thyroid-, retinoic-acid-receptor-associated corepressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_022928.2 RefSeqGene

Range

4853..248050

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001077261.4 → NP_001070729.2 nuclear receptor corepressor 2 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) has multiple difference in the coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter than isoform 1.

Source sequence(s)

AC069261, AC073592, AC073916

Consensus CDS

CCDS41857.2

UniProtKB/TrEMBL

C9JE98

Related

ENSP00000384202.1, ENST00000404621.5

Conserved Domains (4) summary

smart00717
Location:613 → 658

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:613 → 656

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:142 → 228

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl21498
Location:431 → 474

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_001206654.2 → NP_001193583.1 nuclear receptor corepressor 2 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) has multiple difference in the coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter than isoform 1.

Source sequence(s)

AC069261, AC073592, AC073916

Consensus CDS

CCDS55892.1

UniProtKB/TrEMBL

C9J0Q5

Related

ENSP00000400281.2, ENST00000429285.6

Conserved Domains (4) summary

smart00717
Location:613 → 658

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:613 → 656

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:142 → 228

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl21498
Location:431 → 474

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_006312.6 → NP_006303.4 nuclear receptor corepressor 2 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC069261, AC073592, AC073916

Consensus CDS

CCDS41858.2

UniProtKB/Swiss-Prot

O00613, O15416, O15421, Q13354, Q56D06, Q59GM0, Q9Y5U0, Q9Y618

Related

ENSP00000384018.1, ENST00000405201.6

Conserved Domains (6) summary

pfam00249
Location:614 → 657

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:142 → 228

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl21498
Location:432 → 475

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

cl25732
Location:100 → 458

SMC_N; RecF/RecN/SMC N terminal domain

cl26464
Location:909 → 1192

Atrophin-1; Atrophin-1 family

cl27154
Location:541 → 649

SWIRM; SWIRM domain