gltA citrate synthase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: gltA
Official Full Name: citrate synthase
Primary source: ECOCYC:EG10402
Locus tag: b0720
See related: ASAP:ABE-0002451
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK0709; gluT; icdB
Summary: The Escherichia coli citrate synthase is a type II enzyme, which appears to be unique to the Gram-negative bacteria. [More information is available at EcoCyc: EG10402].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Engineered citrate synthase alters Acetate Accumulation in Escherichia coli.
Title: Engineered citrate synthase alters Acetate Accumulation in Escherichia coli.
GltA, icd and mdh do not form a transcription unit, are scattered around the chromosome and are expressed from different promoters.
Title: Interaction of enzymes of the tricarboxylic acid cycle in Bacillus subtilis and Escherichia coli: a comparative study.
N-terminus verified by Edman degradation on mature peptide
Title: Changes in protein synthesis as a consequence of heme depletion in Escherichia coli.
For citrate synthase the change in the number of interdomain contacting atoms upon closure remained largely the same, suggesting that the domain faces slide over each other during closure
Title: Essential dynamics sampling study of adenylate kinase: comparison to citrate synthase and implication for the hinge and shear mechanisms of domain motions.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables NADH binding	IDA Inferred from Direct Assay more info	PubMed
enables acyltransferase activity, acyl groups converted into alkyl on transfer	IEA Inferred from Electronic Annotation more info
enables citrate (Si)-synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables citrate (Si)-synthase activity	IEA Inferred from Electronic Annotation more info
enables citrate (Si)-synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables citrate synthase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein hexamerization	IDA Inferred from Direct Assay more info	PubMed
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed