U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Trpc1 transient receptor potential cation channel, subfamily C, member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 89821, updated on 10-Oct-2024

Summary

Go to the top of the page Help
Symbol
Trpc1provided by RGD
Full Name
transient receptor potential cation channel, subfamily C, member 1provided by RGD
Primary source
RGD:619783
See related
EnsemblRapid:ENSRNOG00000054902 AllianceGenome:RGD:619783
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Trrp1
Summary
Predicted to enable several functions, including ATPase binding activity; inositol 1,4,5 trisphosphate binding activity; and store-operated calcium channel activity. Involved in cellular response to hypoxia. Predicted to be located in basolateral plasma membrane; membrane raft; and myofibril. Predicted to be part of cation channel complex and receptor complex. Predicted to be integral component of plasma membrane. Biomarker of type 2 diabetes mellitus. Orthologous to human TRPC1 (transient receptor potential cation channel subfamily C member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 76.3), Heart (RPKM 61.6) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Trpc1 in Genome Data Viewer
Location:
8q31
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (105142931..105193842, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (96263322..96314220, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (103503982..103554905, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene progestin and adipoQ receptor family member 9 Neighboring gene procollagen C-endopeptidase enhancer 2 Neighboring gene inosine triphosphatase, pseudogene 1 Neighboring gene uncharacterized LOC120094233 Neighboring gene plastin 1 Neighboring gene uncharacterized LOC120094232

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. TRPC1-mediated Ca(2+) signaling enhances intestinal epithelial restitution by increasing α4 association with PP2Ac after wounding. Rathor N, et al. Physiol Rep, 2021 May. PMID 33991460, Free PMC Article
  2. Upregulation of TRPC1 contributes to contractile function in isoproterenol-induced hypertrophic myocardium of rat. Chen MS, et al. Cell Physiol Biochem, 2013. PMID 24107839
  3. TRPC1-mediated Ca2+ and Na+ signalling in astroglia: differential filtering of extracellular cations. Reyes RC, et al. Cell Calcium, 2013 Aug. PMID 23764169, Free PMC Article
  4. TRPC1 expression and distribution in rat hearts. Huang H, et al. Eur J Histochem, 2009 Dec 29. PMID 22073358, Free PMC Article
  5. Knockdown of transient receptor potential canonical-1 reduces the proliferation and migration of endothelial progenitor cells. Kuang CY, et al. Stem Cells Dev, 2012 Feb 10. PMID 21361857, Free PMC Article

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Robust expression of the TRPC1 channel associated with photoreceptor loss in the rat retina.
    Title: Robust expression of the TRPC1 channel associated with photoreceptor loss in the rat retina.
  2. Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1 channels.
    Title: Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1 channels.
  3. TRPC1-mediated Ca(2+) signaling enhances intestinal epithelial restitution by increasing alpha4 association with PP2Ac after wounding.
    Title: TRPC1-mediated Ca(2+) signaling enhances intestinal epithelial restitution by increasing α4 association with PP2Ac after wounding.
  4. TRPC1 mediates slow excitatory synaptic transmission in hippocampal oriens/alveus interneurons.
    Title: TRPC1 mediates slow excitatory synaptic transmission in hippocampal oriens/alveus interneurons.
  5. Location and function of transient receptor potential canonical channel 1 in ventricular myocytes.
    Title: Location and function of transient receptor potential canonical channel 1 in ventricular myocytes.
  6. Specific Upregulation of TRPC1 and TRPC5 Channels by Mineralocorticoid Pathway in Adult Rat Ventricular Cardiomyocytes.
    Title: Specific Upregulation of TRPC1 and TRPC5 Channels by Mineralocorticoid Pathway in Adult Rat Ventricular Cardiomyocytes.
  7. STIM1L/Orai1/TRPC1/C4-dependent Ca(2+) current participates in Ca(2+) remodeling in right ventricular hypertrophy secondary to pulmonary hypertension.
    Title: Ca(2+) handling remodeling and STIM1L/Orai1/TRPC1/TRPC4 upregulation in monocrotaline-induced right ventricular hypertrophy.
  8. In the trigeminal ganglion (TG), 56.1, 84.1, and 68.3% of sensory neurons were immunoreactive (IR) for TRPC1, TRPC3, and TRPC4, respectively.
    Title: TRPC1, TRPC3, and TRPC4 in Rat Orofacial Structures.
  9. 1) TRPC1/4 exert protective effects against SAH-induecd EBI, including cortical cell death and degenerating; 2) TRPC1/4 positively regulated the activity of calcineurin. 3) TRPC1/4 promoted the dephosphorylation of NMDAR via calcineurin.
    Title: Transient receptor potential channel 1/4 reduces subarachnoid hemorrhage-induced early brain injury in rats via calcineurin-mediated NMDAR and NFAT dephosphorylation.
  10. the altered expressions of PPARgamma, TRPC1 and TRPC6 in the pulmonary artery located in the lungs of newborn rats with Persistent pulmonary hypertension of the newborn (PPHN) suggested that these proteins may be important mediators of PPHN.
    Title: Altered expression of PPAR‑γ and TRPC in neonatal rats with persistent pulmonary hypertension.
Submit: New GeneRIF Correction See all GeneRIFs (62)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase binding IEA
Inferred from Electronic Annotation
more info
  
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol 1,4,5 trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol 1,4,5 trisphosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables inositol 1,4,5 trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables store-operated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in melanin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in melanin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of membrane hyperpolarization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in relaxation of vascular associated smooth muscle ISO
Inferred from Sequence Orthology
more info
  
involved_in response to calcium ion IEA
Inferred from Electronic Annotation
more info
  
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within saliva secretion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in costamere ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
short transient receptor potential channel 1
Names
TRP-1
short transient receptor potential channel 1-like
transient receptor protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413355.1 → NP_001400284.1  short transient receptor potential channel 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A0G2K7J3
    Related
    ENSRNOP00000074229.3, ENSRNOT00000089833.3

  2. NM_001429254.1 → NP_001416183.1  short transient receptor potential channel 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I264

  3. NM_053558.3 → NP_446010.2  short transient receptor potential channel 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q9QX01
    Related
    ENSRNOP00000072139.2, ENSRNOT00000079965.3
    Conserved Domains (2) summary
    TIGR00870
    Location:48 → 740
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:83 → 117
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    105142931..105193842 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082220.2 → XP_038938148.1  short transient receptor potential channel 1 isoform X5

    UniProtKB/Swiss-Prot
    Q9QX01
    Conserved Domains (1) summary
    TIGR00870
    Location:25 → 661
    trp; transient-receptor-potential calcium channel protein

  2. XM_063266254.1 → XP_063122324.1  short transient receptor potential channel 1 isoform X2

  3. XM_063266253.1 → XP_063122323.1  short transient receptor potential channel 1 isoform X1

  4. XM_063266255.1 → XP_063122325.1  short transient receptor potential channel 1 isoform X6

  5. XM_039082218.2 → XP_038938146.1  short transient receptor potential channel 1 isoform X3

    UniProtKB/TrEMBL
    Q0PG39
    Conserved Domains (1) summary
    TIGR00870
    Location:14 → 695
    trp; transient-receptor-potential calcium channel protein

  6. XM_039082219.2 → XP_038938147.1  short transient receptor potential channel 1 isoform X4

    UniProtKB/Swiss-Prot
    Q9QX01
    Conserved Domains (1) summary
    TIGR00870
    Location:48 → 684
    trp; transient-receptor-potential calcium channel protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QX01.1 GenPept UniProtKB/Swiss-Prot:Q9QX01

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous