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mpt83 cell surface lipoprotein [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887155, updated on 6-Jun-2024

Summary

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Gene symbol
mpt83
Gene description
cell surface lipoprotein
Locus tag
Rv2873
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
mpb83
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Genomic context

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Sequence:
NC_000962.3 (3183905..3184567)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene 1-deoxy-D-xylulose 5-phosphate reductoisomerase Neighboring gene antitoxin VapB43 Neighboring gene ribonuclease VapC43 Neighboring gene integral membrane C-type cytochrome biogenesis protein DipZ Neighboring gene major secreted immunogenic protein Mpt70

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mycobacterium tuberculosis antigens MPT63 and MPT83 increase phagocytic activity of murine peritoneal macrophages.
    Title: Mycobacterium tuberculosis antigens MPT63 and MPT83 increase phagocytic activity of murine peritoneal macrophages.
  2. results established a proapoptotic effect of MPT83 and identified the TLR2/p38/COX-2 axis in MPT83-induced macrophage apoptosis
    Title: Mycobacterium tuberculosis Lipoprotein MPT83 Induces Apoptosis of Infected Macrophages by Activating the TLR2/p38/COX-2 Signaling Pathway.
  3. Recombinant MPT83 is a Toll-like receptor (TLR)2 agonist that induces the production of cytokines by macrophages and upregulates macrophage function.
    Title: Recombinant MPT83 derived from Mycobacterium tuberculosis induces cytokine production and upregulates the function of mouse macrophages through TLR2.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
cell surface lipoprotein
NP_217389.1
  • Mpt83 (lipoprotein P23)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3183905..3184567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217389.1 cell surface lipoprotein [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217389.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3LJZ7
    Conserved Domains (1) summary
    COG2335
    Location:31 → 220
    FAS1; Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WNF3.1

Gene LinkOut

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Molecular Biology Databases