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ponA2 bifunctional penicillin-insensitive transglycosylase/penicillin-sensitive transpeptidase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885751, updated on 11-Dec-2020

Summary

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Gene symbol
ponA2
Gene description
bifunctional penicillin-insensitive transglycosylase/penicillin-sensitive transpeptidase
Locus tag
Rv3682
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (4121916..4124348)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene anion transporter ATPase Neighboring gene anion transporter ATPase Neighboring gene transcriptional regulator WhiB4 Neighboring gene hypothetical protein Neighboring gene lyase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosis. Calvanese L, et al. Biopolymers, 2014 Jul. PMID 24281824
  2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that, despite a high structural similarity with other PASTA domains, the PASTA domain of penicillin binding protein PonA2 displays different binding properties.
    Title: Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
bifunctional penicillin-insensitive transglycosylase/penicillin-sensitive transpeptidase
YP_178005.1
  • membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    4121916..4124348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_178005.1 bifunctional penicillin-insensitive transglycosylase/penicillin-sensitive transpeptidase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for YP_178005.1

    Status: PROVISIONAL

    Conserved Domains (3) summary
    cd06577
    Location:703 → 761
    PASTA_pknB; PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis. ...
    COG0744
    Location:12 → 708
    MrcB; Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis]
    sd00037
    Location:703 → 760
    PASTA; PASTA domain [structural motif]
Nucleotide Protein
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