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PIAS1 protein inhibitor of activated STAT 1 [ Homo sapiens (human) ]

Gene ID: 8554, updated on 3-Nov-2024

Summary

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Official Symbol
PIAS1provided by HGNC
Official Full Name
protein inhibitor of activated STAT 1provided by HGNC
Primary source
HGNC:HGNC:2752
See related
Ensembl:ENSG00000033800 MIM:603566; AllianceGenome:HGNC:2752
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GBP; ZMIZ3; DDXBP1; GU/RH-II
Summary
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in thyroid (RPKM 10.0), ovary (RPKM 9.9) and 25 other tissues See more
Orthologs
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Genomic context

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See PIAS1 in Genome Data Viewer
Location:
15q23
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (68054315..68193847)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (65875930..66012597)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (68346653..68486185)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:68132321-68133273 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:68133274-68134225 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68138024-68138524 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68138525-68139025 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:68145177-68145734 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr15:68145735-68146290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9636 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68152060-68152560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9638 Neighboring gene RNA, U6 small nuclear 1 Neighboring gene CRISPRi-validated cis-regulatory element chr15.1880 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:68210766-68211352 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_40776 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:68238558-68239757 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9639 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9640 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_40781 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68260831-68261747 Neighboring gene ribosomal protein S15a pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:68299513-68300103 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:68301209-68302094 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:68302095-68302980 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:68308948-68309655 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:68312077-68312615 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:68312616-68313153 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:68314382-68315165 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68337310-68337830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68337831-68338350 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6583 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68361989-68362489 Neighboring gene uncharacterized LOC105370871 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:68492859-68493630 Neighboring gene Sharpr-MPRA regulatory region 569 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68503536-68504076 Neighboring gene calmodulin like 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9641 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9642 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:68521930-68522109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9643 Neighboring gene CLN6 transmembrane ER protein Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:68549209-68549856 Neighboring gene uncharacterized LOC124903593 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 40

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Protein inhibitor of activated STAT-1 is downregulated in gastric cancer tissue and involved in cell metastasis. Chen P, et al. Oncol Rep, 2012 Dec. PMID 22972521
  2. PIAS1 is increased in human prostate cancer and enhances proliferation through inhibition of p21. Hoefer J, et al. Am J Pathol, 2012 May. PMID 22449952
  3. The expression of protein inhibitor of activated signal transducers and activators of transcription 3 in the evolutionary process of gastric cancer. Liu LM, et al. Eur J Intern Med, 2011 Oct. PMID 21925039
  4. The SUMO E3-ligase PIAS1 couples reactive oxygen species-dependent JNK activation to oxidative cell death. Leitao BB, et al. FASEB J, 2011 Oct. PMID 21676946, Free PMC Article
  5. SUMO Ligase Protein Inhibitor of Activated STAT1 (PIAS1) Is a Constituent Promyelocytic Leukemia Nuclear Body Protein That Contributes to the Intrinsic Antiviral Immune Response to Herpes Simplex Virus 1. Brown JR, et al. J Virol, 2016 Jul 1. PMID 27099310, Free PMC Article

See all (258) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p/NUPR1/FTH1 axis.
    Title: CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p/NUPR1/FTH1 axis.
  2. Multi-omics integration identifies cell-state-specific repression by PBRM1-PIAS1 cooperation.
    Title: Multi-omics integration identifies cell-state-specific repression by PBRM1-PIAS1 cooperation.
  3. SUMOylation and coupling of eNOS mediated by PIAS1 contribute to maintenance of vascular homeostasis.
    Title: SUMOylation and coupling of eNOS mediated by PIAS1 contribute to maintenance of vascular homeostasis.
  4. SUMOylation of SMAD4 by PIAS1 in Conjunction with Vimentin Upregulation Promotes Migration Potential in Non-Small Cell Lung Cancer.
    Title: SUMOylation of SMAD4 by PIAS1 in Conjunction with Vimentin Upregulation Promotes Migration Potential in Non-Small Cell Lung Cancer.
  5. Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin.
    Title: Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin.
  6. A PIAS1 Protective Variant S510G Delays polyQ Disease Onset by Modifying Protein Homeostasis.
    Title: A PIAS1 Protective Variant S510G Delays polyQ Disease Onset by Modifying Protein Homeostasis.
  7. Roles of the SUMO-related enzymes, PIAS1, PIAS4, and RNF4, in DNA double-strand break repair by homologous recombination.
    Title: Roles of the SUMO-related enzymes, PIAS1, PIAS4, and RNF4, in DNA double-strand break repair by homologous recombination.
  8. Expression of PIAS Genes in Migraine Patients.
    Title: Expression of PIAS Genes in Migraine Patients.
  9. PIAS1 and TIF1gamma collaborate to promote SnoN SUMOylation and suppression of epithelial-mesenchymal transition.
    Title: PIAS1 and TIF1γ collaborate to promote SnoN SUMOylation and suppression of epithelial-mesenchymal transition.
  10. Linking nuclear matrix-localized PIAS1 to chromatin SUMOylation via direct binding of histones H3 and H2A.Z.
    Title: Linking nuclear matrix-localized PIAS1 to chromatin SUMOylation via direct binding of histones H3 and H2A.Z.
Submit: New GeneRIF Correction See all GeneRIFs (80)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC141878, MGC141879

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
  
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables SUMO transferase activity EXP
Inferred from Experiment
more info
 PubMed 
enables SUMO transferase activity TAS
Traceable Author Statement
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity TAS
Traceable Author Statement
more info
 PubMed 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway via JAK-STAT TAS
Traceable Author Statement
more info
 PubMed 
involved_in fat cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein localization to cell periphery IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein sumoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein sumoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein sumoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein sumoylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein sumoylation TAS
Traceable Author Statement
more info
  
involved_in protein-DNA complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in visual learning IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
colocalizes_with PML body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear periphery ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in presynaptic cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 SUMO-protein ligase PIAS1
Names
AR interacting protein
DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1
DEAD/H box-binding protein 1
E3 SUMO-protein transferase PIAS1
RNA helicase II-binding protein
gu-binding protein
protein inhibitor of activated STAT protein 1
zinc finger, MIZ-type containing 3
NP_001307616.1
NP_057250.1
XP_011520428.1
XP_011520429.1
XP_016878177.1
XP_016878178.1
XP_047289153.1
XP_054235009.1
XP_054235010.1
XP_054235011.1
XP_054235012.1
XP_054235013.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320687.1 → NP_001307616.1  E3 SUMO-protein ligase PIAS1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA837658, AC107871, AC135628, AK094641
    Consensus CDS
    CCDS81902.1
    UniProtKB/TrEMBL
    A4ZVS7
    Related
    ENSP00000438574.1, ENST00000545237.1
    Conserved Domains (3) summary
    smart00513
    Location:13 → 47
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:333 → 381
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:137 → 273
    PINIT; PINIT domain

  2. NM_016166.3 → NP_057250.1  E3 SUMO-protein ligase PIAS1 isoform 2

    See identical proteins and their annotated locations for NP_057250.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' structure which results in a distinct 5' UTR and 5' coding region compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AA837658, AC107871, AF167160
    Consensus CDS
    CCDS45290.1
    UniProtKB/Swiss-Prot
    B2RB67, B3KSY9, C5J4B4, O75925, Q147X4, Q99751, Q9UN02
    UniProtKB/TrEMBL
    A4ZVS7
    Related
    ENSP00000249636.6, ENST00000249636.11
    Conserved Domains (3) summary
    smart00513
    Location:11 → 45
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:332 → 379
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:137 → 285
    PINIT; PINIT domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    68054315..68193847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022688.2 → XP_016878177.1  E3 SUMO-protein ligase PIAS1 isoform X2

    UniProtKB/TrEMBL
    A4ZVS7
    Conserved Domains (3) summary
    smart00513
    Location:13 → 47
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:333 → 381
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:137 → 273
    PINIT; PINIT domain

  2. XM_011522126.3 → XP_011520428.1  E3 SUMO-protein ligase PIAS1 isoform X1

    UniProtKB/TrEMBL
    A4ZVS7
    Conserved Domains (3) summary
    smart00513
    Location:20 → 54
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:340 → 388
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:144 → 280
    PINIT; PINIT domain

  3. XM_017022689.2 → XP_016878178.1  E3 SUMO-protein ligase PIAS1 isoform X4

    UniProtKB/TrEMBL
    A4ZVS7
    Conserved Domains (3) summary
    smart00513
    Location:4 → 38
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:325 → 372
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:130 → 278
    PINIT; PINIT domain

  4. XM_011522127.3 → XP_011520429.1  E3 SUMO-protein ligase PIAS1 isoform X3

    UniProtKB/TrEMBL
    A4ZVS7
    Conserved Domains (3) summary
    smart00513
    Location:5 → 39
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:326 → 373
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:131 → 279
    PINIT; PINIT domain

  5. XM_047433197.1 → XP_047289153.1  E3 SUMO-protein ligase PIAS1 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    65875930..66012597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379034.1 → XP_054235009.1  E3 SUMO-protein ligase PIAS1 isoform X2

  2. XM_054379036.1 → XP_054235011.1  E3 SUMO-protein ligase PIAS1 isoform X4

  3. XM_054379035.1 → XP_054235010.1  E3 SUMO-protein ligase PIAS1 isoform X3

  4. XM_054379038.1 → XP_054235013.1  E3 SUMO-protein ligase PIAS1 isoform X5

  5. XM_054379037.1 → XP_054235012.1  E3 SUMO-protein ligase PIAS1 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75925.2 GenPept UniProtKB/Swiss-Prot:O75925

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